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Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

Biochimica et biophysica acta. Reviews on cancer, 2019-04, Vol.1871 (2), p.434-454

2019

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The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases

Oncogene, 2019-07, Vol.38 (29), p.5817-5837

2019

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HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity

Current biology, 2007-01, Vol.17 (2), p.165-172

2007

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The Gli code: an information nexus regulating cell fate, stemness and cancer

Trends in cell biology, 2007-09, Vol.17 (9), p.438-447

2007

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (14), p.5895-5900

2007

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The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer

EMBO molecular medicine, 2014-10, Vol.6 (10), p.1263-1278

2014

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Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling

PloS one, 2016-03, Vol.11 (3), p.e0150697-e0150697

2016

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A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12

EMBO molecular medicine, 2014-07, Vol.6 (7), p.882-901

2014

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex

Development (Cambridge), 2004-01, Vol.131 (2), p.337-345

2004

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Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?

Cancer cell, 2008-10, Vol.14 (4), p.281-283

Ruiz i Altaba, Ariel

2008

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Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells

PloS one, 2016-12, Vol.11 (12), p.e0168170-e0168170

2016

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Sonic hedgehog regulates the growth and patterning of the cerebellum

Development (Cambridge), 1999-07, Vol.126 (14), p.3089-3100

1999

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

Development (Cambridge), 2005-01, Vol.132 (2), p.335-344

2005

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Loss of WNT‐TCF addiction and enhancement of HH‐GLI1 signalling define the metastatic transition of human colon carcinomas

EMBO molecular medicine, 2010-11, Vol.2 (11), p.440-457

2010

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Loss-of-Function Mutations in the Human GLI2 Gene Are Associated with Pituitary Anomalies and Holoprosencephaly-like Features

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13424-13429

2003

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Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

Seminars in cell & developmental biology, 2014-09, Vol.33 (100), p.93-104

2014

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On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm

Cell reports (Cambridge), 2022-03, Vol.38 (10), p.110490-110490, Article 110490

2022

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Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP

Neural development, 2008-05, Vol.3 (1), p.13-13, Article 13

2008

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NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

The EMBO journal, 2010-08, Vol.29 (15), p.2659-2674

2010

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Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

EMBO molecular medicine, 2009-09, Vol.1 (6‐7), p.338-351

2009

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Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1

Cell reports (Cambridge), 2020-11, Vol.33 (6), p.108372-108372, Article 108372

2020

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Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

Biochemical pharmacology, 2010-09, Vol.80 (5), p.712-723

2010

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Gli and hedgehog in cancer: tumours, embryos and stem cells

Nature reviews. Cancer, 2002-05, Vol.2 (5), p.361-372

2002

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Cooperative requirement of the Gli proteins in neurogenesis

Development (Cambridge), 2005-07, Vol.132 (14), p.3267-3279

2005

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Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer

EMBO reports, 2009-08, Vol.10 (8), p.832-836

2009

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Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases

HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity

The Gli code: an information nexus regulating cell fate, stemness and cancer

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer

Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling

A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex

Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells

Sonic hedgehog regulates the growth and patterning of the cerebellum

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

Loss of WNT‐TCF addiction and enhancement of HH‐GLI1 signalling define the metastatic transition of human colon carcinomas

Loss-of-Function Mutations in the Human GLI2 Gene Are Associated with Pituitary Anomalies and Holoprosencephaly-like Features

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm

Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

Gli and hedgehog in cancer: tumours, embryos and stem cells

Cooperative requirement of the Gli proteins in neurogenesis

Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer

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