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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.528-537

1997

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Development of a Hydrogenative Reductive Amination for the Synthesis of Evacetrapib: Unexpected Benefits of Water

Organic process research & development, 2014-04, Vol.18 (4), p.546-551

2014

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Synthesis of PPAR Agonist via Asymmetric Hydrogenation of a Cinnamic Acid Derivative and Stereospecific Displacement of (S)-2-Chloropropionic Acid

Organic letters, 2005-05, Vol.7 (10), p.1947-1950

2005

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Process Development and Pilot-Plant Synthesis of (2-Chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone

Organic process research & development, 2010-09, Vol.14 (5), p.1229-1238

2010

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Application of Heterogeneous Acid Catalysts to the Large-Scale Synthesis of 2- and 3-(p-Methoxyphenyl)-6-methoxybenzo[b]thiophenes

Organic process research & development, 1999-01, Vol.3 (1), p.56-59

1999

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2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.51-55

2005

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Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (24), p.6328-6333

2006

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Process Development of (1S,2S,5R,6S)- Spiro[bicyclo[3.1.0]hexane-2‘,5‘-dioxo-2,4‘-imidazolidine]-6-carboxylic Acid, (R)-α-Methylbenzenemethanamine Salt (LSN344309)

Organic process research & development, 2006-01, Vol.10 (1), p.28-32

2006

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How to Convert a Walk-in Hood into a Manufacturing Facility: Demonstration of a Continuous, High-Temperature Cyclization to Process Solids in Flow

Organic process research & development, 2014-11, Vol.18 (11), p.1482-1491

2014

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An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

Tetrahedron letters, 2008-11, Vol.49 (48), p.6749-6751

2008

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Counterion effects in the preparation of aldehyde–bisulfite adducts

Tetrahedron letters, 2013-11, Vol.54 (48), p.6587-6591

2013

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Design, Development, and Execution of a Continuous‐flow‐Enabled API Manufacturing Route

Organometallic Chemistry in Industry, 2020

2020

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ChemInform Abstract: Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues

ChemInform, 2015-03, Vol.46 (9), p.no-no

2015

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Efficient Fast Screening Methodology for Optical Resolution Agents: Solvent Effects Are Used To Affect the Efficiency of the Resolution Process

Organic process research & development, 2004-05, Vol.8 (3), p.532-534

2004

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ChemInform Abstract: An Expedient Synthesis of 3-Substituted Indoles via Reductive Alkylation with Ketones

ChemInform, 2009-03, Vol.40 (10), p.no-no

2009

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Synthesis of [ 11C]dapoxetine · HCl, a serotonin re-uptake inhibitor: Biodistribution in rat and preliminary PET imaging in the monkey

Nuclear medicine and biology, 1994, Vol.21 (4), p.669-675

1994

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The Role of Short-Chain Fatty Acids in Health and Disease

Advances in Immunology, 2014, Vol.121, p.91-119

2014

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Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond

Advances in immunology, 2019, Vol.142, p.35

2019

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Direct measurement of local oxygen concentration in the bone marrow of live animals

Nature (London), 2014-04, Vol.508 (7495), p.269-273

2014

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Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy

PloS one, 2017-10, Vol.12 (10), p.e0186846-e0186846

2017

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Self-renewal of a purified Tie2⁺ hematopoietic stem cell population relies on mitochondrial clearance

Science (American Association for the Advancement of Science), 2016-12, Vol.354 (6316), p.1156-1160

2016

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Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells

Stem cells and development, 2010-12, Vol.19 (12), p.1875

2010

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M-1/M-2 Macrophages and the Th1/Th2 Paradigm

The Journal of immunology (1950), 2000-06, Vol.164 (12), p.6166-6173

2000

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Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

Translational oncology, 2019-10, Vol.12 (10), p.1314-1322

2019

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Macrophages coordinate immune response to laser-induced injury via extracellular traps

Journal of neuroinflammation, 2024-03, Vol.21 (1), p.68-68, Article 68

2024

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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Development of a Hydrogenative Reductive Amination for the Synthesis of Evacetrapib: Unexpected Benefits of Water

Synthesis of PPAR Agonist via Asymmetric Hydrogenation of a Cinnamic Acid Derivative and Stereospecific Displacement of (S)-2-Chloropropionic Acid

Process Development and Pilot-Plant Synthesis of (2-Chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone

Application of Heterogeneous Acid Catalysts to the Large-Scale Synthesis of 2- and 3-(p-Methoxyphenyl)-6-methoxybenzo[b]thiophenes

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents

Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands

Process Development of (1S,2S,5R,6S)- Spiro[bicyclo[3.1.0]hexane-2‘,5‘-dioxo-2,4‘-imidazolidine]-6-carboxylic Acid, (R)-α-Methylbenzenemethanamine Salt (LSN344309)

How to Convert a Walk-in Hood into a Manufacturing Facility: Demonstration of a Continuous, High-Temperature Cyclization to Process Solids in Flow

An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

Counterion effects in the preparation of aldehyde–bisulfite adducts

Design, Development, and Execution of a Continuous‐flow‐Enabled API Manufacturing Route

ChemInform Abstract: Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues

Efficient Fast Screening Methodology for Optical Resolution Agents: Solvent Effects Are Used To Affect the Efficiency of the Resolution Process

ChemInform Abstract: An Expedient Synthesis of 3-Substituted Indoles via Reductive Alkylation with Ketones

Synthesis of [ 11C]dapoxetine · HCl, a serotonin re-uptake inhibitor: Biodistribution in rat and preliminary PET imaging in the monkey

The Role of Short-Chain Fatty Acids in Health and Disease

Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond

Direct measurement of local oxygen concentration in the bone marrow of live animals

Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy

Self-renewal of a purified Tie2⁺ hematopoietic stem cell population relies on mitochondrial clearance

Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

Macrophages coordinate immune response to laser-induced injury via extracellular traps

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