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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

ChemMedChem, 2009-05, Vol.4 (5), p.853-865

2009

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NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

British journal of pharmacology, 2002-07, Vol.136 (5), p.773-783

2002

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Pharmacological actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: in vitro studies

British journal of pharmacology, 2002-01, Vol.135 (2), p.333-343

2002

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Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones

Journal of organic chemistry, 2005-11, Vol.70 (23), p.9463-9469

2005

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Cover Picture: Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009)

ChemMedChem, 2009-05, Vol.4 (5), p.693-693

2009

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NO-independent regulatory site on soluble guanylate cyclase

Nature (London), 2001-03, Vol.410 (6825), p.212-215

2001

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A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway

Analytical biochemistry, 2005-04, Vol.339 (1), p.104-112

2005

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NO-Independent stimulators of soluble guanylate cyclase

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (6), p.781-784

2001

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Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1H)-ones Using in situ Generated Propiolic Acid Chloride

Synthesis (Stuttgart), 2005-11, Vol.2005 (18), p.3085-3094

2005

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Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis

Arzneimittel-Forschung, 2008-01, Vol.58 (2), p.71-80

2008

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Sequenced Reactions with Samarium(II) Iodide. Sequential Intermolecular Carbonyl Addition/Intramolecular Nucleophilic Acyl Substitution for the Preparation of Seven-, Eight-, and Nine-Membered Carbocycles

Journal of organic chemistry, 1998-06, Vol.63 (13), p.4366-4373

1998

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Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1 H )-ones Using in situ Generated Propiolic Acid Chloride

Synthesis (Stuttgart), 2005, Vol.2005 (18), p.3085-3094

2005

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A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines

Tetrahedron letters, 2004, Vol.45 (1), p.95-98

2004

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Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1H)-ones Using in situ Generated Propiolic Acid Chloride

ChemInform, 2006-03, Vol.37 (13), p.no-no

2006

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A novel approach to amidines from esters

Tetrahedron letters, 2002-01, Vol.43 (3), p.419-421

2002

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A Convenient Synthesis of 4-Alkoxy- and 4-Hydroxy-2,6-difluoroanilines

ChemInform, 2004-04, Vol.35 (15), p.no-no

2004

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Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones

ChemInform, 2006-03, Vol.37 (12), p.no-no

2006

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NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272

BMC pharmacology, 2001-12, Vol.1 (1), p.13-13, Article 13

2001

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ChemInform Abstract: A Novel Approach to Amidines from Esters

ChemInform, 2002-04, Vol.33 (15), p.no-no

2002

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ChemInform Abstract: NO-Independent Stimulators of Soluble Guanylate Cyclase

ChemInform, 2001-07, Vol.32 (27), p.no-no

2001

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Opening of cyclopropyl ketones with SmI2. Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile

Tetrahedron, 1997-06, Vol.53 (24), p.8067-8084

1997

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Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies

British journal of pharmacology, 2002, Vol.135 (2), p.333-343

2002

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Opening of cyclopropyl ketones with SmI 2. Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile

Tetrahedron, 1997, Vol.53 (24), p.8067-8084

1997

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Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension

BMC pharmacology, 2009-08, Vol.9 (S1), p.P52-P52, Article P52

2009

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Design and synthesis of the first NO- and haem-independent sGC activator BAY 58–2667 for the treatment of acute decompensated heart failure

BMC pharmacology, 2007-07, Vol.7 (S1), p.P25-P25, Article P25

2007

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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

Pharmacological actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: in vitro studies

Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones

Cover Picture: Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009)

NO-independent regulatory site on soluble guanylate cyclase

A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway

NO-Independent stimulators of soluble guanylate cyclase

Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1H)-ones Using in situ Generated Propiolic Acid Chloride

Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis

Sequenced Reactions with Samarium(II) Iodide. Sequential Intermolecular Carbonyl Addition/Intramolecular Nucleophilic Acyl Substitution for the Preparation of Seven-, Eight-, and Nine-Membered Carbocycles

Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1 H )-ones Using in situ Generated Propiolic Acid Chloride

A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines

Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1H)-ones Using in situ Generated Propiolic Acid Chloride

A novel approach to amidines from esters

A Convenient Synthesis of 4-Alkoxy- and 4-Hydroxy-2,6-difluoroanilines

Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones

NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272

ChemInform Abstract: A Novel Approach to Amidines from Esters

ChemInform Abstract: NO-Independent Stimulators of Soluble Guanylate Cyclase

Opening of cyclopropyl ketones with SmI2. Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile

Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies

Opening of cyclopropyl ketones with SmI 2. Synthesis of spirocyclic and bicyclic ketones by intramolecular trapping of an electrophile

Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension

Design and synthesis of the first NO- and haem-independent sGC activator BAY 58–2667 for the treatment of acute decompensated heart failure

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