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Supplementing clinical lactation studies with PBPK modeling to inform drug therapy in lactating mothers: Prediction of primaquine exposure as a case example

CPT: pharmacometrics and systems pharmacology, 2024-03, Vol.13 (3), p.386-395

2024

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PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Clinical and translational science, 2024-07, Vol.17 (7), p.e13865-n/a

2024

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Development and application of a PBPK modeling strategy to support antimalarial drug development

CPT: pharmacometrics and systems pharmacology, 2023-09, Vol.12 (9), p.1335-1346

2023

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Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19

Clinical pharmacology and therapeutics, 2022-06, Vol.111 (6), p.1324-1333

2022

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Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

Clinical pharmacology and therapeutics, 2020-11, Vol.108 (5), p.976-984

2020

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A tutorial on physiologically based pharmacokinetic approaches in lactation research

CPT: pharmacometrics and systems pharmacology, 2024-09

2024

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Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Drug metabolism and disposition, 2016-06, Vol.44 (6), p.821-832

2016

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Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: Mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series

Pharmacotherapy, 2023-04, Vol.43 (4), p.291-299

2023

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Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

CPT: pharmacometrics and systems pharmacology, 2024-10

2024

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Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing

Toxicological sciences, 2014-11, Vol.142 (1), p.210-224

2014

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Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

Clinical pharmacokinetics, 2011-12, Vol.50 (12), p.809-822

2011

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Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals

Journal of antimicrobial chemotherapy, 2005-10, Vol.56 (4), p.738-744

2005

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Intracellular and plasma pharmacokinetics of nevirapine in human immunodeficiency virus-infected individuals

Clinical pharmacology and therapeutics, 2005-08, Vol.78 (2), p.132-142

2005

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The relationship between nevirapine plasma concentrations and abnormal liver function tests

AIDS research and human retroviruses, 2004-07, Vol.20 (7), p.716-722

2004

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Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea

AIDS (London), 2002-12, Vol.16 (18), p.2439-2446

2002

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Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients

Clinical pharmacokinetics, 2011-12, Vol.50 (12), p.809

2011

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Intracellular and plasma pharmacoldnetics of nevirapine in human immunodeficiency virus-infected individuals

Clinical pharmacology and therapeutics, 2005, Vol.78 (2), p.132-142

2005

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Prospective Trial of a Pediatric Ventricular Assist Device

The New England journal of medicine, 2012-08, Vol.367 (6), p.532-541

2012

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Consensus Statement: Hemostasis Trial Outcomes in Cardiac Surgery and Mechanical Support

The Annals of thoracic surgery, 2022-03, Vol.113 (3), p.1026-1035

2022

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Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation

Molecular & cellular proteomics, 2022-07, Vol.21 (7), p.100247, Article 100247

2022

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An in vitro toolbox to accelerate anti-malarial drug discovery and development

Malaria journal, 2020-01, Vol.19 (1), p.1-1, Article 1

2020

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Supplemental nutrition, feeding disorders, and renourishment in pediatric heart failure through transplantation

Pediatric transplantation, 2023-12, Vol.27 (8), p.e14601

2023

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Biomolecular and micromorphological analysis of suspected faecal deposits at Neolithic Çatalhöyük, Turkey

Journal of archaeological science, 2011-08, Vol.38 (8), p.1869-1877

2011

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Impact of ventricular assist device implantation on the nutritional status of children awaiting heart transplantation

Pediatric transplantation, 2019-03, Vol.23 (2), p.e13351-n/a

2019

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The use of FT-IR as a screening technique for organic residue analysis of archaeological samples

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2009-02, Vol.72 (1), p.120-125

2009

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Supplementing clinical lactation studies with PBPK modeling to inform drug therapy in lactating mothers: Prediction of primaquine exposure as a case example

PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Development and application of a PBPK modeling strategy to support antimalarial drug development

Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

A tutorial on physiologically based pharmacokinetic approaches in lactation research

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: Mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals

Intracellular and plasma pharmacokinetics of nevirapine in human immunodeficiency virus-infected individuals

The relationship between nevirapine plasma concentrations and abnormal liver function tests

Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients

Intracellular and plasma pharmacoldnetics of nevirapine in human immunodeficiency virus-infected individuals

Prospective Trial of a Pediatric Ventricular Assist Device

Consensus Statement: Hemostasis Trial Outcomes in Cardiac Surgery and Mechanical Support

Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Supplemental nutrition, feeding disorders, and renourishment in pediatric heart failure through transplantation

Biomolecular and micromorphological analysis of suspected faecal deposits at Neolithic Çatalhöyük, Turkey

Impact of ventricular assist device implantation on the nutritional status of children awaiting heart transplantation

The use of FT-IR as a screening technique for organic residue analysis of archaeological samples

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