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Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal

Drug metabolism reviews, 2011-02, Vol.43 (1), p.1-26

2011

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Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models

Biology (Basel, Switzerland), 2020-11, Vol.9 (12), p.419

2020

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Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

Acta pharmaceutica Sinica. B, 2020-01, Vol.10 (1), p.42-60

2020

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Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Scientific reports, 2016-10, Vol.6 (1), p.35169-35169, Article 35169

2016

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Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame

Drug metabolism reviews, 2016-07, Vol.48 (3), p.405-433

2016

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Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1637-1649

2008

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Hepatic cytochrome P450 ubiquitination: Conformational phosphodegrons for E2/E3 recognition?

IUBMB life, 2014-02, Vol.66 (2), p.78-88

2014

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A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation

The Journal of biological chemistry, 2009-02, Vol.284 (9), p.5671-5684

2009

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CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile

Drug metabolism and disposition, 2008-03, Vol.36 (3), p.490-499

2008

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CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

Archives of biochemistry and biophysics, 2009-03, Vol.483 (1), p.66-74

2009

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Structure–function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase

Archives of biochemistry and biophysics, 2003, Vol.409 (1), p.113-126

2003

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Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination

Molecular & cellular proteomics, 2012-02, Vol.11 (2), p.M111, Article M111.010132

2012

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Hepatic Protoporphyrin IX activates NF‐kB inflammatory pathway through a non‐canonical mechanism

The FASEB journal, 2019-04, Vol.33 (S1), p.lb4-lb4

2019

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Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

The Journal of biological chemistry, 2011-02, Vol.286 (5), p.3815-3828

2011

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Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: Further Characterization of Cellular Participants and Structural Determinants

Molecular pharmacology, 2006-06, Vol.69 (6), p.1897-1904

2006

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Cytochrome P450 ubiquitination: Branding for the proteolytic slaughter?

Annual review of pharmacology and toxicology, 2005-01, Vol.45 (1), p.439-464

2005

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Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation Brigade

Drug metabolism reviews, 2003-01, Vol.35 (2-3), p.107-143

Correia, Maria Almira

2003

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Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes: A Role for the Cytosolic AAA ATPase p97?

Biochemistry (Easton), 2007-07, Vol.46 (26), p.7793-7803

2007

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Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

The Journal of biological chemistry, 2010-11, Vol.285 (46), p.35866-35877

2010

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Role of SQSTM1/p62 in Cytochrome P450 Autophagy?

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Heme: A Regulator of Rat Hepatic Tryptophan 2,3-Dioxygenase?

Archives of biochemistry and biophysics, 2000-05, Vol.377 (1), p.195-203

2000

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In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization

Molecular & cellular proteomics, 2023-02, Vol.22 (2), p.100495, Article 100495

2023

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Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.985-990

2002

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Influence of liver‐specific ablation of gp78 E3‐ligase on hepatic cytochrome P450‐ dependent drug metabolism: Clinical implications

The FASEB journal, 2018-04, Vol.32 (S1), p.833.1-833.1

2018

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Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance

Molecular pharmacology, 2019-11, Vol.96 (5), p.641-654

2019

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Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal

Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models

Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

Hepatic cytochrome P450 ubiquitination: Conformational phosphodegrons for E2/E3 recognition?

A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation

CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

Structure–function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase

Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination

Hepatic Protoporphyrin IX activates NF‐kB inflammatory pathway through a non‐canonical mechanism

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: Further Characterization of Cellular Participants and Structural Determinants

Cytochrome P450 ubiquitination: Branding for the proteolytic slaughter?

Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation Brigade

Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes: A Role for the Cytosolic AAA ATPase p97?

Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

Role of SQSTM1/p62 in Cytochrome P450 Autophagy?

Heme: A Regulator of Rat Hepatic Tryptophan 2,3-Dioxygenase?

In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization

Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4

Influence of liver‐specific ablation of gp78 E3‐ligase on hepatic cytochrome P450‐ dependent drug metabolism: Clinical implications

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance

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