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Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition

European journal of medicinal chemistry, 2019-11, Vol.182, p.111592-111592, Article 111592

2019

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Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives

Molecules (Basel, Switzerland), 2013-12, Vol.18 (12), p.15035-15050

2013

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Compostos coordenados híbridos de platina no tratamento do câncer

Revista de ciências farmacêuticas básica e aplicada, 2014-07, Vol.35 (3)

2014

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Curricularização da Extensão Universitária no Ensino Médico: o Encontro das Gerações para Humanização da Formação

Revista brasileira de educação médica, 2020-01, Vol.43 (1 suppl 1), p.672-680

2020

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Different cell death responses induced by eupomatenoid-5 in MCF-7 and 786-0 tumor cell lines

Toxicology in vitro, 2015-08, Vol.29 (5), p.1026-1033

2015

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Novel indole-thiazole and indole-thiazolidinone derivatives as DNA groove binders

International journal of biological macromolecules, 2021-02, Vol.170, p.622-635

2021

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Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives

International journal of molecular sciences, 2015-06, Vol.16 (6), p.13023-13042

2015

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Spiro-acridine inhibiting tyrosinase enzyme: Kinetic, protein-ligand interaction and molecular docking studies

International journal of biological macromolecules, 2019-02, Vol.122, p.289-297

2019

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Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives

Bioorganic & medicinal chemistry, 2018-11, Vol.26 (20), p.5388-5396

2018

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Albumin roles in developing anticancer compounds

Medicinal chemistry research, 2021-08, Vol.30 (8), p.1469-1495

2021

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ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation

Pharmaceuticals (Basel, Switzerland), 2023-01, Vol.16 (2), p.204

2023

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Lectin-carbohydrate complex evaluation by chemiluminescence

Analytical biochemistry, 2018-05, Vol.548, p.91-95

2018

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Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Results in Chemistry, 2024-01, Vol.7, p.101371, Article 101371

2024

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Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives

Bioorganic & medicinal chemistry, 2018-12, Vol.26 (22), p.5911-5921

2018

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Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay

European journal of medicinal chemistry, 2017-08, Vol.136, p.305-314

2017

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COVID-19 therapy: What weapons do we bring into battle?

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (23), p.115757-115757, Article 115757

2020

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Study of nitrogen heterocycles as DNA/HSA binder, topoisomerase inhibitors and toxicological safety

International journal of biological macromolecules, 2024-01, Vol.254 (Pt 3), p.127651-127651, Article 127651

2024

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Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities

European journal of medicinal chemistry, 2017-08, Vol.136, p.511-522

2017

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DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?

Biomedicine & pharmacotherapy, 2017-12, Vol.96, p.1538-1556

2017

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Peer-Assisted and Team-Based Learning: A new hybrid strategy for Medical Education

Revista brasileira de educação médica, 2018-09, Vol.42 (3), p.162-170

2018

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A simple method for obtaining human albumin and its use for in vitro interaction assays with indole-thiazole and indole-thiazolidinone derivatives

International journal of biological macromolecules, 2021-12, Vol.192, p.126-137

2021

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New thiophene–acridine compounds: Synthesis, antileishmanial activity, DNA binding, chemometric, and molecular docking studies

Chemical biology & drug design, 2018-06, Vol.91 (6), p.1141-1155

2018

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Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives

International journal of biological macromolecules, 2019-10, Vol.138, p.582-589

2019

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New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases

International journal of biological macromolecules, 2016-11, Vol.92, p.467-475

2016

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Compostos coordenados híbridos de platina no tratamento do câncer

Revista de ciências farmacêuticas básica e aplicada, 2014-08, Vol.35 (3), p.337-345

2014

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Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition

Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives

Compostos coordenados híbridos de platina no tratamento do câncer

Curricularização da Extensão Universitária no Ensino Médico: o Encontro das Gerações para Humanização da Formação

Different cell death responses induced by eupomatenoid-5 in MCF-7 and 786-0 tumor cell lines

Novel indole-thiazole and indole-thiazolidinone derivatives as DNA groove binders

Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives

Spiro-acridine inhibiting tyrosinase enzyme: Kinetic, protein-ligand interaction and molecular docking studies

Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives

Albumin roles in developing anticancer compounds

ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation

Lectin-carbohydrate complex evaluation by chemiluminescence

Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay

COVID-19 therapy: What weapons do we bring into battle?

Study of nitrogen heterocycles as DNA/HSA binder, topoisomerase inhibitors and toxicological safety

Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities

DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?

Peer-Assisted and Team-Based Learning: A new hybrid strategy for Medical Education

A simple method for obtaining human albumin and its use for in vitro interaction assays with indole-thiazole and indole-thiazolidinone derivatives

New thiophene–acridine compounds: Synthesis, antileishmanial activity, DNA binding, chemometric, and molecular docking studies

Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives

New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases

Compostos coordenados híbridos de platina no tratamento do câncer

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