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Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action

Biomedicines, 2022-07, Vol.10 (8), p.1767

Allison, Simon J

2022

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SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways

Cell cycle (Georgetown, Tex.), 2007-11, Vol.6 (21), p.2669-2677

2007

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The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets

Cancer science, 2021-09, Vol.112 (9), p.3822-3834

2021

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Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Nature communications, 2021-06, Vol.12 (1), p.3898-15, Article 3898

2021

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Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Scientific reports, 2016-09, Vol.6 (1), p.33026, Article 33026

2016

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Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer

Genome Biology, 2023-08, Vol.24 (1), p.191-191, Article 191

2023

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Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells

Pharmacology research & perspectives, 2023-12, Vol.11 (6), p.e01152-n/a

2023

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Anticancer metallohelices: nanomolar potency and high selectivity

Chemical science (Cambridge), 2016-01, Vol.7 (2), p.951-958

2016

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SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53

PloS one, 2010-10, Vol.5 (10), p.e13502-e13502

2010

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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

Molecular therapy. Nucleic acids, 2014-01, Vol.3 (1), p.e141-e141, Article e141

2014

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SIRT1, p53 and mitotic chromosomes

Cell cycle (Georgetown, Tex.), 2011-09, Vol.10 (18), p.3049-3049

2011

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A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes

Molecular and Cellular Biology, 2012-02, Vol.32 (3), p.704-716

2012

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Investigation of the cytotoxicity induced by didocosahexaenoin, an omega 3 derivative, in human prostate carcinoma cell lines

Current research in pharmacology and drug discovery, 2022, Vol.3, p.100085-100085, Article 100085

2022

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Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target

Biochemical Society transactions, 2020-06, Vol.48 (3), p.733-744

2020

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Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

Open biology, 2013-11, Vol.3 (11), p.130130-130130

2013

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Development and characterization of a microfluidic model of the tumour microenvironment

Scientific reports, 2016-10, Vol.6 (1), p.36086, Article 36086

2016

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An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells

Planta medica, 2021-08, Vol.87 (10/11), p.892-895

2021

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Preclinical Evaluation of Zn(II) Self‐Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

Chemistry : a European journal, 2024-01, Vol.30 (3), p.e202302803-n/a

2024

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Hypoxia-Sensitive Metal β‑Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Journal of medicinal chemistry, 2015-06, Vol.58 (12), p.4940-4953

2015

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Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Chemical science (Cambridge), 2019-10, Vol.10 (37), p.8547-8557

2019

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Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells

Angewandte Chemie International Edition, 2018-07, Vol.57 (31), p.9799-9804

International ed. in English, 2018

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Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

Angewandte Chemie International Edition, 2020-08, Vol.59 (34), p.14677-14685

International ed. in English, 2020

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KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

Science translational medicine, 2018-08, Vol.10 (454)

2018

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RNA Polymerase III Transcription Factor TFIIIC2 Is Overexpressed in Ovarian Tumors

Proceedings of the National Academy of Sciences - PNAS, 2000-11, Vol.97 (23), p.12619-12624

2000

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Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action

SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways

The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer

Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells

Anticancer metallohelices: nanomolar potency and high selectivity

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

SIRT1, p53 and mitotic chromosomes

A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes

Investigation of the cytotoxicity induced by didocosahexaenoin, an omega 3 derivative, in human prostate carcinoma cell lines

Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

Development and characterization of a microfluidic model of the tumour microenvironment

An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells

Preclinical Evaluation of Zn(II) Self‐Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

Hypoxia-Sensitive Metal β‑Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

RNA Polymerase III Transcription Factor TFIIIC2 Is Overexpressed in Ovarian Tumors

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