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Direct Carbon Isotope Exchange through Decarboxylative Carboxylation

Journal of the American Chemical Society, 2019-01, Vol.141 (2), p.774-779

2019

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Chemoselective Methionine Bioconjugation: Site-Selective Fluorine-18 Labeling of Proteins and Peptides

Bioconjugate chemistry, 2020-08, Vol.31 (8), p.1908-1916

2020

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Fully Validated LC-MS/MS Assay for the Simultaneous Quantitation of Coadministered Therapeutic Antibodies in Cynomolgus Monkey Serum

Analytical chemistry (Washington), 2013-10, Vol.85 (20), p.9859-9867

2013

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Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Protein engineering, design and selection, 2018-05, Vol.31 (5), p.159-171

2018

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Metabolism and disposition of dasatinib after oral administration to humans

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1357-1364

2008

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Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples

The AAPS journal, 2015-09, Vol.17 (5), p.1168-1176

2015

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Synthesis of 2-(14)C-iminothiolane and 2-(13)C,(15)N-iminothiolane (Traut's reagent)

Journal of labelled compounds & radiopharmaceuticals, 2015-09, Vol.58 (11-12), p.429-432

2015

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Synthesis of 2-14C-iminothiolane and 2-13C,15N-iminothiolane (Traut's reagent)

Journal of labelled compounds & radiopharmaceuticals, 2015-09, Vol.58 (11-12), p.429-432

2015

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Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target

Bioanalysis, 2014-09, Vol.6 (18), p.2371-2383

2014

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Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates

Journal of labelled compounds & radiopharmaceuticals, 2014-07, Vol.57 (9), p.579-583

2014

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Synthesis of acyl[35S]sulfonamides: Coupling of high specific activity [35S]methane sulfonamide with acids and acid chlorides

Journal of labelled compounds & radiopharmaceuticals, 2012-11, Vol.55 (13), p.474-476

2012

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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (13), p.3249-3254

2018

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Convenient and efficient tritiation of aristolochic acid I (AAI) and aristolochic acid II (AAII) with tritiated water

Journal of labelled compounds & radiopharmaceuticals, 2007-04, Vol.50 (5-6), p.433-434

2007

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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3228-3250

2019

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Synthesis of an adenine N-3 substituted CBI adduct by alkylation of adenine with a 1-iodomethylindoline seco-CBI precursor

Tetrahedron, 2018-11, Vol.74 (46), p.6680-6688

2018

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Synthesis and analysis of tritiated camptothecin analogs with iridium-mediated 3H exchange

Journal of labelled compounds & radiopharmaceuticals, 2007-04, Vol.50 (5-6), p.459-462

2007

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Radiochemistry challenges and progression for incorporation of 18F into a complex substituted 6-18F-fluoroquinoline BMS-986205 for IDO imaging

The Journal of nuclear medicine (1978), 2018-05, Vol.59, p.605

2018

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Radiochemistry challenges and progression for incorporation of ^sup 18^F into a complex substituted 6-^sup 18^F-fluoroquinoline BMS-986205 for IDO imaging

The Journal of nuclear medicine (1978), 2018-05, Vol.59, p.605

2018

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The 14C, 13C, and 15N syntheses of a potent VEGFR-2 kinase inhibitor, Brivanib, and its prodrug, Brivanib Alaninate

Journal of labelled compounds & radiopharmaceuticals, 2011-05, Vol.54 (6), p.324-331

2011

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Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS

Analytical chemistry (Washington), 2019-07, Vol.91 (13), p.8443-8452

2019

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A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study

Journal of pharmaceutical and biomedical analysis, 2019-02, Vol.165, p.198-206

2019

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Comparisons of Hydroperoxide Isomerase and Monooxygenase Activities of Cytochrome P450 for Conversions of Allylic Hydroperoxides and Alcohols to Epoxyalcohols and Diols: Probing Substrate Reorientation in the Active Site

Biochemistry (Easton), 2001-09, Vol.40 (38), p.11490-11501

2001

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Innovative Use of LC-MS/MS for Simultaneous Quantitation of Neutralizing Antibody, Residual Drug, and Human Immunoglobulin G in Immunogenicity Assay Development

Analytical chemistry (Washington), 2014-03, Vol.86 (5), p.2673-2680

2014

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Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants

Journal of the American Chemical Society, 1992-12, Vol.114 (25), p.9744-9749

1992

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Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics

Analytica chimica acta, 2016-04, Vol.916, p.42-51

2016

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Direct Carbon Isotope Exchange through Decarboxylative Carboxylation

Chemoselective Methionine Bioconjugation: Site-Selective Fluorine-18 Labeling of Proteins and Peptides

Fully Validated LC-MS/MS Assay for the Simultaneous Quantitation of Coadministered Therapeutic Antibodies in Cynomolgus Monkey Serum

Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Metabolism and disposition of dasatinib after oral administration to humans

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples

Synthesis of 2-(14)C-iminothiolane and 2-(13)C,(15)N-iminothiolane (Traut's reagent)

Synthesis of 2-14C-iminothiolane and 2-13C,15N-iminothiolane (Traut's reagent)

Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target

Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates

Synthesis of acyl[35S]sulfonamides: Coupling of high specific activity [35S]methane sulfonamide with acids and acid chlorides

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Convenient and efficient tritiation of aristolochic acid I (AAI) and aristolochic acid II (AAII) with tritiated water

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Synthesis of an adenine N-3 substituted CBI adduct by alkylation of adenine with a 1-iodomethylindoline seco-CBI precursor

Synthesis and analysis of tritiated camptothecin analogs with iridium-mediated 3H exchange

Radiochemistry challenges and progression for incorporation of 18F into a complex substituted 6-18F-fluoroquinoline BMS-986205 for IDO imaging

Radiochemistry challenges and progression for incorporation of ^sup 18^F into a complex substituted 6-^sup 18^F-fluoroquinoline BMS-986205 for IDO imaging

The 14C, 13C, and 15N syntheses of a potent VEGFR-2 kinase inhibitor, Brivanib, and its prodrug, Brivanib Alaninate

Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS

A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study

Comparisons of Hydroperoxide Isomerase and Monooxygenase Activities of Cytochrome P450 for Conversions of Allylic Hydroperoxides and Alcohols to Epoxyalcohols and Diols: Probing Substrate Reorientation in the Active Site

Innovative Use of LC-MS/MS for Simultaneous Quantitation of Neutralizing Antibody, Residual Drug, and Human Immunoglobulin G in Immunogenicity Assay Development

Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics

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