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Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3233-3237

2006

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The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.123-126

2007

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Design, Synthesis, and in Vivo SAR of a Novel Series of Pyrazolines as Potent Selective Androgen Receptor Modulators

Journal of medicinal chemistry, 2007-08, Vol.50 (16), p.3857-3869

2007

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Pharmacological characterization of an imidazolopyrazole as novel selective androgen receptor modulator

The Journal of steroid biochemistry and molecular biology, 2013-03, Vol.134, p.51-58

2013

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Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5763-5766

2006

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Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1784-1787

2007

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Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.439-443

2007

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A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

Endocrine, 2007-08, Vol.32 (1), p.41-51

2007

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Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.784-788

2007

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2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.955-958

2007

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Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activities

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5754-5757

2007

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The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

Cell, 1992-05, Vol.69 (4), p.703-713

1992

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Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen

The Journal of steroid biochemistry and molecular biology, 2004-08, Vol.91 (4), p.225-239

2004

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Molecular properties and preclinical pharmacology of JNJ-1250132, a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro

Steroids, 2006-07, Vol.71 (7), p.578-584

2006

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β-Alkylthio indolyl carbinols: Potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2545-2548

2007

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Nonsteroidal progesterone receptor ligands with unprecedented receptor selectivity

The Journal of steroid biochemistry and molecular biology, 2000-12, Vol.75 (1), p.33-42

2000

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An Ultrahigh-Throughput Screening Assay for Estrogen Receptor Ligands

Analytical biochemistry, 1999-11, Vol.275 (2), p.243-247

1999

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Ligand-Dependent Conformational Changes in the Progesterone Receptor are Necessary for Events that Follow DNA Binding

Proceedings of the National Academy of Sciences - PNAS, 1992-12, Vol.89 (24), p.11750-11754

1992

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Therapeutic androgen receptor ligands

Nuclear receptor signaling, 2003, Vol.1 (1), p.e009-e009

2003

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Induction of the progesterone receptor gene in estrogen target cells monitored by branched DNA signal amplification

Steroids, 2001-09, Vol.66 (9), p.663-671

2001

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Identification of Genes with Differential Regulation in Primate Endometrium During the Proliferative and Secretory Phases of the Cycle

Endocrine research, 2003-01, Vol.29 (1), p.53-65

2003

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Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation

The Journal of biological chemistry, 1992-09, Vol.267 (27), p.19513-19520

1992

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Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain

Molecular endocrinology (Baltimore, Md.), 1993-10, Vol.7 (10), p.1266-1274

1993

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Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5754-5757

2007

Volltextzugriff (PDF)

Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (gilz) GILZ by estrogen

The Journal of steroid biochemistry and molecular biology, 2004, Vol.91 (4-5), p.225-239

2004

Volltextzugriff (PDF)

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