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Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

Journal of allergy and clinical immunology, 2016-09, Vol.138 (3), p.700-710

2016

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Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a

Immunology letters, 2010-01, Vol.128 (1), p.36-45

Ali, Hydar

2010

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Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions

Advances in immunology, 2017, Vol.136, p.123-162

Ali, Hydar

2017

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Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant

The Journal of immunology (1950), 2018-07, Vol.201 (2), p.343-349

2018

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GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells

Frontiers in immunology, 2023-03, Vol.14, p.1155777-1155777

2023

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Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

Current allergy and asthma reports, 2021-01, Vol.21 (1), p.3-3, Article 3

2021

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Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

International journal of molecular sciences, 2021-05, Vol.22 (10), p.5318

2021

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Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1

Respiratory research, 2018-01, Vol.19 (1), p.1-1, Article 1

2018

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Identification of Gain and Loss of Function Missense Variants in MRGPRX2's Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P

International journal of molecular sciences, 2019-10, Vol.20 (21), p.5247

2019

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Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs

Current opinion in immunology, 2021-10, Vol.72, p.65-71

Ali, Hydar

2021

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Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells

Frontiers in immunology, 2022-06, Vol.13, p.892239-892239

2022

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Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2

Frontiers in immunology, 2021-06, Vol.12, p.689410

2021

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Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells

The Journal of immunology (1950), 2019-02, Vol.202 (4), p.1229-1238

2019

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Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

Frontiers in immunology, 2022-10, Vol.13, p.1033794

2022

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GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

Frontiers in immunology, 2022-10, Vol.13, p.1032497-1032497

2022

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Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases

PloS one, 2011-07, Vol.6 (7), p.e22559-e22559

2011

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Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide

Infection and immunity, 2017-10, Vol.85 (10)

2017

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Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells

Cells (Basel, Switzerland), 2021-02, Vol.10 (2), p.376

2021

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Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells

Frontiers in immunology, 2022-01, Vol.12, p.803335

2022

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G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2

European journal of pharmacology, 2011-10, Vol.668 (1-2), p.299-304

2011

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Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells

PloS one, 2011-05, Vol.6 (5), p.e19585-e19585

2011

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Enhanced Development of Functional Murine Mast Cells in Human Stem Cell Factor Transgenic Immune-Deficient Mice

Journal of allergy and clinical immunology, 2016-02, Vol.137 (2), p.AB78-AB78

2016

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The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion

Cells (Basel, Switzerland), 2024-01, Vol.13 (1), p.93

2024

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Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells

PloS one, 2012-10, Vol.7 (10), p.e46369

2012

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MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

Cells (Basel, Switzerland), 2021-01, Vol.10 (1), p.156

2021

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Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a

Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions

Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells

Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization

Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1

Identification of Gain and Loss of Function Missense Variants in MRGPRX2's Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P

Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs

Spatiotemporal Patterns of Substance P-Bound MRGPRX2 Reveal a Novel Connection Between Macropinosome Resolution and Secretory Granule Regeneration in Mast Cells

Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2

Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells

Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases

Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide

Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells

Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2

Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells

Enhanced Development of Functional Murine Mast Cells in Human Stem Cell Factor Transgenic Immune-Deficient Mice

The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion

Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells

MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants

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