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Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

Bone (New York, N.Y.), 2018-04, Vol.109, p.251-258

2018

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A new class of small molecule inhibitor of BMP signaling

PloS one, 2013-04, Vol.8 (4), p.e62721

2013

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Nature chemical biology, 2016-10, Vol.12 (10), p.876-884

2016

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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Nature genetics, 2014-05, Vol.46 (5), p.457-461

2014

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ACVR1 Mutations in DIPG: Lessons Learned from FOP

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4565-4570

2014

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Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

Biochemical journal, 2017-11, Vol.474 (22), p.3747-3761

2017

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Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Cancer cell, 2020-03, Vol.37 (3), p.308-323.e12

2020

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Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

The Journal of biological chemistry, 2012-10, Vol.287 (44), p.36990-36998

2012

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Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Biochemical journal, 2014-06, Vol.460 (2), p.237-246

2014

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Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9710-9715

2013

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The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

Science signaling, 2018-05, Vol.11 (531)

2018

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Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

Scientific reports, 2019-12, Vol.9 (1), p.18351-10, Article 18351

2019

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Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.7900-7915

2014

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Targeted protein degradation: expanding the toolbox

Nature reviews. Drug discovery, 2019-12, Vol.18 (12), p.949-963

2019

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systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (51), p.20523-20528

2007

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CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

Cell reports (Cambridge), 2018-01, Vol.22 (4), p.885-894

2018

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Structural basis of Keap1 interactions with Nrf2

Free radical biology & medicine, 2015-11, Vol.88 (Pt B), p.101-107

2015

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Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

ACS chemical biology, 2013-06, Vol.8 (6), p.1291-1302

2013

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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

Scientific reports, 2024-01, Vol.14 (1), p.328-328, Article 328

2024

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New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

Biochemical Society transactions, 2014-02, Vol.42 (1), p.103-107

2014

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Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3390-3404

2015

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A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

Angiogenesis (London), 2015-04, Vol.18 (2), p.209-217

2015

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Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

European journal of medicinal chemistry, 2020-08, Vol.200, p.112417-112417, Article 112417

2020

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Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

ACS chemical biology, 2013-10, Vol.8 (10), p.2145-2150

2013

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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

Molecules (Basel, Switzerland), 2021-07, Vol.26 (14), p.4353

2021

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Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2

A new class of small molecule inhibitor of BMP signaling

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

ACVR1 Mutations in DIPG: Lessons Learned from FOP

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

Targeted protein degradation: expanding the toolbox

systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

Structural basis of Keap1 interactions with Nrf2

Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

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