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Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs

Chemical research in toxicology, 2019-01, Vol.32 (1), p.156-167

2019

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Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Chemical research in toxicology, 2011-09, Vol.24 (9), p.1345-1410

2011

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Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential

Chemical research in toxicology, 2020-01, Vol.33 (1), p.223-238

2020

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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Chemical research in toxicology, 2017-05, Vol.30 (5), p.1219-1229

2017

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Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Acta pharmaceutica Sinica. B, 2021-12, Vol.11 (12), p.3857-3868

2021

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Principles of precision medicine and its application in toxicology

The Journal of Toxicological Sciences, 2018, Vol.43(10), pp.565-577

2018

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Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Toxicology and applied pharmacology, 2013-10, Vol.272 (2), p.272-280

2013

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Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology (Baltimore, Md.), 2014-09, Vol.60 (3), p.1015-1022

2014

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Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays

Toxicological sciences, 2015-10, Vol.147 (2), p.500-514

2015

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Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction

Chemical research in toxicology, 2020-07, Vol.33 (7), p.1780-1790

2020

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A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues

Chemical research in toxicology, 2020-01, Vol.33 (1), p.258-270

2020

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AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules

Chemical research in toxicology, 2023-07, Vol.36 (7), p.1129-1139

2023

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Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Pharmacology research & perspectives, 2019-12, Vol.7 (6), p.e00523-n/a

2019

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Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

Drug metabolism reviews, 2012-02, Vol.44 (1), p.127-140

2012

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Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

Pharmacology research & perspectives, 2019-02, Vol.7 (1), p.e00467-n/a

2019

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An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury

Archives of toxicology, 2021, Vol.95 (1), p.149-168

2021

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Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5308-5312

2010

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Liver safety evaluation of endothelin receptor antagonists using HepatoPac®: A single model impact assessment on hepatocellular health, function and bile acid disposition

Journal of applied toxicology, 2019-08, Vol.39 (8), p.1192-1207

2019

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Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9771-9779

2013

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Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Chemical research in toxicology, 2017-06, Vol.30 (6), p.1365-1365

2017

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Ciglitazone-induced lenticular opacities in rats: in vivo and whole lens explant culture evaluation

The Journal of pharmacology and experimental therapeutics, 2005-03, Vol.312 (3), p.1027

2005

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Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies

Toxicology letters, 2010-09, Vol.197 (3), p.175-182

2010

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Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

Chemical research in toxicology, 2016-10, Vol.29 (10), p.1778-1788

2016

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Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products

Journal of applied toxicology, 2019-09, Vol.39 (9), p.1348-1361

2019

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1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes

Investigative ophthalmology & visual science, 2013-11, Vol.54 (12), p.7189-7197

2013

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Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Principles of precision medicine and its application in toxicology

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays

Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction

A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues

AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis

An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

Liver safety evaluation of endothelin receptor antagonists using HepatoPac®: A single model impact assessment on hepatocellular health, function and bile acid disposition

Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies

Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Ciglitazone-induced lenticular opacities in rats: in vivo and whole lens explant culture evaluation

Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis

Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products

1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes

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