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Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

Drug discovery today, 2020-09, Vol.25 (9), p.1624-1638

2020

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Xenobiotic, bile acid, and cholesterol transporters: function and regulation

Pharmacological reviews, 2010-03, Vol.62 (1), p.1

2010

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Regulation of Placental Efflux Transporters during Pregnancy Complications

Drug metabolism and disposition, 2022-10, Vol.50 (10), p.1364-1375

2022

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Xenobiotic transporters and kidney injury

Advanced drug delivery reviews, 2017-07, Vol.116, p.73-91

2017

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Inherited disorders of bilirubin clearance

Pediatric research, 2016-03, Vol.79 (3), p.378-386

2016

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Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1366

2012

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An Interactive Pharmacogenetics Lesson Using PharmGKB To Individualize Pharmacotherapy Recommendations

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach

Environmental science & technology, 2021-08, Vol.55 (15), p.10875-10887

2021

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Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species

Expert opinion on drug metabolism & toxicology, 2020-03, Vol.16 (3), p.239-253

2020

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Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay

Journal of hazardous materials, 2022-08, Vol.436, p.129193-129193, Article 129193

2022

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Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy

Experimental biology and medicine (Maywood, N.J.), 2018-02, Vol.243 (3), p.272-282

2018

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Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals

Reproductive toxicology (Elmsford, N.Y.), 2022-01, Vol.107, p.60-68

2022

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Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.459-480

2020

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Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Environmental health perspectives, 2019-04, Vol.127 (4), p.47001

2019

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Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

PloS one, 2015-02, Vol.10 (2), p.e0112655

2015

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Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

PloS one, 2018-08, Vol.13 (8), p.e0200004

2018

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Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity

Journal of hazardous materials, 2024-06, Vol.471, p.134297-134297, Article 134297

2024

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High-throughput screening of toxicants that modulate extravillous trophoblast migration

Toxicology letters, 2023-02, Vol.375, p.1-7

2023

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Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier

Advanced healthcare materials, 2018-01, Vol.7 (2), p.n/a

2018

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Renoprotective Effects of Melatonin against Vancomycin-Related Acute Kidney Injury in Hospitalized Patients: a Retrospective Cohort Study

Antimicrobial agents and chemotherapy, 2021-08, Vol.65 (9), p.e0046221

2021

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Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways

Environmental science & technology, 2023-08, Vol.57 (33), p.12291-12301

2023

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Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

Toxicological sciences, 2009-10, Vol.111 (2), p.238-246

2009

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Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data

Toxicological sciences, 2020-04, Vol.174 (2), p.178-188

2020

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Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

Biochemical pharmacology, 2009-04, Vol.77 (7), p.1273-1282

2009

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BCRP/ ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity

Drug metabolism and disposition, 2021-08, Vol.49 (8), p.629-637

2021

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Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

Xenobiotic, bile acid, and cholesterol transporters: function and regulation

Regulation of Placental Efflux Transporters during Pregnancy Complications

Xenobiotic transporters and kidney injury

Inherited disorders of bilirubin clearance

Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice

An Interactive Pharmacogenetics Lesson Using PharmGKB To Individualize Pharmacotherapy Recommendations

Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach

Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species

Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay

Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy

Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals

Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity

High-throughput screening of toxicants that modulate extravillous trophoblast migration

Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier

Renoprotective Effects of Melatonin against Vancomycin-Related Acute Kidney Injury in Hospitalized Patients: a Retrospective Cohort Study

Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

BCRP/ ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity

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