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EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity

Oncoimmunology, 2017-08, Vol.6 (8), p.e1338239-e1338239

2017

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A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity

Oncoimmunology, 2024, Vol.13 (1), p.2316945-2316945

2024

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BCL11B is required for positive selection and survival of double-positive thymocytes

The Journal of experimental medicine, 2007-11, Vol.204 (12), p.3003-3015

2007

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Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (15), p.6211-6216

2011

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Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

The Journal of experimental medicine, 2011-09, Vol.208 (10), p.2069-2081

2011

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Intranasal Vaccination Using Interleukin-12 and Cholera Toxin Subunit B as Adjuvants To Enhance Mucosal and Systemic Immunity to Human Immunodeficiency Virus Type 1 Glycoproteins

Journal of Virology, 2003-05, Vol.77 (10), p.5589-5597

2003

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BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes

Blood, 2006-10, Vol.108 (8), p.2695-2702

2006

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Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b

The Journal of experimental medicine, 2010-08, Vol.207 (8), p.1687-1699

2010

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Flow cytometry analysis of transcription factors in T lymphocytes

Methods in molecular biology (Clifton, N.J.), 2010, Vol.647, p.377

2010

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Abstract 3431: Dose range finding study in non-human primates confirms the unique mechanism of action of CTX-8371, a novel bispecific antibody blocking PD-1 and PD-L1

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3431-3431

2022

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Bispecific anti-PD-1/PD-L1 antibody CTX-8371 to promote cellular clustering and PD-1 shedding, antitumor activity and tolerability

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.e15056-e15056

2021

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Abstract 4586: Intratumoral Treg cell depletion by local administration of IL-2-Diphteria toxin fusion protein E7777 induces a therapeutic and memory anti-tumor immune response in preclinical models

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4586-4586

2017

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Abstract 4607: Specific inhibition of PGE2-EP4 signaling by E7046 promotes anti-tumor activity of checkpoint blockade agents through boosting cytotoxic T cell activity

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4607-4607

2017

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Abstract 1227: Macrophage depletion enhances the anticancer efficacy of eribulin mesylate in mice bearing syngeneic tumors

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.1227-1227

2013

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Abstract B198: Pharmacological profile of the PGE2 EP4 receptor antagonist E7046

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.B198-B198

2015

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Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.275-275

2015

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Abstract B90: Eribulin mesylate alters immune homeostasis in mice bearing syngeneic tumors

Cancer research (Chicago, Ill.), 2013-01, Vol.73 (1_Supplement), p.B90-B90

2013

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Abstract B034: Preclinical immune antitumor activity of myeloid-targeting E7046 and Treg depleting E7777

Cancer immunology research, 2016-01, Vol.4 (1_Supplement), p.B034-B034

2016

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Low-Grade Myofibroblastic Sarcoma of the Larynx

The Journal of craniofacial surgery, 2016-05, Vol.27 (3), p.e270-e271

2016

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Full-Mouth Rehabilitation of a Patient with Gummy Smile-Multidisciplinary Approach: Case Report

Medicina (Kaunas, Lithuania), 2023-01, Vol.59 (2), p.197

2023

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Influence of the Operator`s Experience, Working Time, and Working Position on the Quality of the Margin Width: In Vitro Study

Medicina (Kaunas, Lithuania), 2023-01, Vol.59 (2), p.244

2023

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Development of New Collagen/Clay Composite Biomaterials

International journal of molecular sciences, 2021-12, Vol.23 (1), p.401

2021

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Optimization of the Fermentation Conditions for Brewing Yeast Biomass Production Using the Response Surface Methodology and Taguchi Technique

Agriculture (Basel), 2021-12, Vol.11 (12), p.1237

2021

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Development of Innovative Biocomposites with Collagen, Keratin and Hydroxyapatite for Bone Tissue Engineering

Biomimetics (Basel, Switzerland), 2024-07, Vol.9 (7), p.428

2024

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Magnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma

Medicina (Kaunas, Lithuania), 2024-05, Vol.60 (5), p.708

2024

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EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity

A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity

BCL11B is required for positive selection and survival of double-positive thymocytes

Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

Intranasal Vaccination Using Interleukin-12 and Cholera Toxin Subunit B as Adjuvants To Enhance Mucosal and Systemic Immunity to Human Immunodeficiency Virus Type 1 Glycoproteins

BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes

Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b

Flow cytometry analysis of transcription factors in T lymphocytes

Abstract 3431: Dose range finding study in non-human primates confirms the unique mechanism of action of CTX-8371, a novel bispecific antibody blocking PD-1 and PD-L1

Bispecific anti-PD-1/PD-L1 antibody CTX-8371 to promote cellular clustering and PD-1 shedding, antitumor activity and tolerability

Abstract 4586: Intratumoral Treg cell depletion by local administration of IL-2-Diphteria toxin fusion protein E7777 induces a therapeutic and memory anti-tumor immune response in preclinical models

Abstract 4607: Specific inhibition of PGE2-EP4 signaling by E7046 promotes anti-tumor activity of checkpoint blockade agents through boosting cytotoxic T cell activity

Abstract 1227: Macrophage depletion enhances the anticancer efficacy of eribulin mesylate in mice bearing syngeneic tumors

Abstract B198: Pharmacological profile of the PGE2 EP4 receptor antagonist E7046

Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs

Abstract B90: Eribulin mesylate alters immune homeostasis in mice bearing syngeneic tumors

Abstract B034: Preclinical immune antitumor activity of myeloid-targeting E7046 and Treg depleting E7777

Low-Grade Myofibroblastic Sarcoma of the Larynx

Full-Mouth Rehabilitation of a Patient with Gummy Smile-Multidisciplinary Approach: Case Report

Influence of the Operator`s Experience, Working Time, and Working Position on the Quality of the Margin Width: In Vitro Study

Development of New Collagen/Clay Composite Biomaterials

Optimization of the Fermentation Conditions for Brewing Yeast Biomass Production Using the Response Surface Methodology and Taguchi Technique

Development of Innovative Biocomposites with Collagen, Keratin and Hydroxyapatite for Bone Tissue Engineering

Magnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma

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