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Effect of Clofarabine on Apoptosis and DNA Synthesis in Human Epithelial Colon Cancer Cells

Nucleosides, nucleotides & nucleic acids, 2010-06, Vol.29 (4-6), p.414-418

2010

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Mechanisms of anti-cancer action and pharmacology of clofarabine

Biochemical pharmacology, 2009-12, Vol.78 (11), p.1351-1359

2009

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Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells

Leukemia & lymphoma, 2008-01, Vol.49 (3), p.410-426

2008

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High activity and incomplete cross resistance of nucleoside analogues cladribine and fludarabine versus Ara-C on leukemic cells from patients with AML

Therapeutic drug monitoring, 2005-10, Vol.27 (5), p.641-646

2005

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Thiopurines: Factors influencing toxicity and response

Biochemical pharmacology, 2010-05, Vol.79 (9), p.1211-1220

2010

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Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity

European journal of cancer (1990), 1999-12, Vol.35 (13), p.1862-1867

1999

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On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration

Journal of clinical oncology, 1992-10, Vol.10 (10), p.1514-1518

1992

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Low-dose oral pulse methotrexate as monotherapy in elderly patients with bullous pemphigoid

Journal of the American Academy of Dermatology, 1999-05, Vol.40 (5), p.741-749

1999

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Regulation of p53R2 and its role as potential target for cancer therapy

Cancer letters, 2009-04, Vol.276 (1), p.1-7

2009

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Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia

Journal of clinical oncology, 1995-04, Vol.13 (4), p.989-995

1995

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Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia

Leukemia, 2002-03, Vol.16 (3), p.386-392

2002

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Pharmacokinetics of cladribine in plasma and its 5'-monophosphate and 5'-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia

Clinical cancer research, 1998-03, Vol.4 (3), p.653-658

1998

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Impaired Transport as a Mechanism of Resistance to Thiopurines in Human T-Lymphoblastic Leukemia Cells

Nucleosides, nucleotides & nucleic acids, 2006-01, Vol.25 (9-11), p.1039-1044

2006

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Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

Biochemical and biophysical research communications, 2006-04, Vol.343 (1), p.208-215

2006

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Differences in cytosolic and mitochondrial 5′-nucleotidase and deoxynucleoside kinase activities in Sprague–Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models

Toxicology (Amsterdam), 2010, Vol.267 (1), p.159-164

2010

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Effect of clofarabine on apoptosis and DNA synthesis in human breast cancer

CANCER RESEARCH, 2012, Vol.72

2012

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The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells

Biochemical and biophysical research communications, 2011-07, Vol.411 (1), p.156-161

2011

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Analysis of DNA methylation of the 5′ region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine (CAFdA)-resistant cells

Cancer letters, 1998-08, Vol.130 (1), p.169-174

1998

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Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes

Biochemical and biophysical research communications, 2007-06, Vol.357 (4), p.847-853

2007

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Monitoring of methotrexate and 7-hydroxymethotrexate in saliva from children with acute lymphoblastic leukemia receiving high-dose consolidation treatment: relation to oral mucositis

Anti-cancer drugs, 1997, Vol.8 (2), p.119

1997

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Expression of deoxynucleoside kinases and 5′-nucleotidases in mouse tissues: Implications for mitochondrial toxicity

Biochemical pharmacology, 2007-06, Vol.74 (1), p.169-175

2007

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Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance

Biochemical pharmacology, 2003, Vol.65 (2), p.237-247

2003

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Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

Biochemical pharmacology, 2009-04, Vol.77 (8), p.1410-1417

2009

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Activity profiles of deoxynucleoside kinases and 5′-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs

Biochemical pharmacology, 2005-03, Vol.69 (6), p.951-960

2005

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Distribution of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, Fludarabine and Cytarabine in mice : a whole-body autoradiography study

Medical oncology (Northwood, London, England), 1999-12, Vol.16 (4), p.239-244

1999

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Effect of Clofarabine on Apoptosis and DNA Synthesis in Human Epithelial Colon Cancer Cells

Mechanisms of anti-cancer action and pharmacology of clofarabine

Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells

High activity and incomplete cross resistance of nucleoside analogues cladribine and fludarabine versus Ara-C on leukemic cells from patients with AML

Thiopurines: Factors influencing toxicity and response

Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity

On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration

Low-dose oral pulse methotrexate as monotherapy in elderly patients with bullous pemphigoid

Regulation of p53R2 and its role as potential target for cancer therapy

Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia

Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia

Pharmacokinetics of cladribine in plasma and its 5'-monophosphate and 5'-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia

Impaired Transport as a Mechanism of Resistance to Thiopurines in Human T-Lymphoblastic Leukemia Cells

Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

Differences in cytosolic and mitochondrial 5′-nucleotidase and deoxynucleoside kinase activities in Sprague–Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models

Effect of clofarabine on apoptosis and DNA synthesis in human breast cancer

The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells

Analysis of DNA methylation of the 5′ region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine (CAFdA)-resistant cells

Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes

Monitoring of methotrexate and 7-hydroxymethotrexate in saliva from children with acute lymphoblastic leukemia receiving high-dose consolidation treatment: relation to oral mucositis

Expression of deoxynucleoside kinases and 5′-nucleotidases in mouse tissues: Implications for mitochondrial toxicity

Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

Activity profiles of deoxynucleoside kinases and 5′-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs

Distribution of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, Fludarabine and Cytarabine in mice : a whole-body autoradiography study

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