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S.24.04 Glycine reuptake inhibitor bitopertin: characterisation in relation to symptom domains in schizophrenia

European neuropsychopharmacology, 2013-10, Vol.23, p.S147-S147

Alberati, D

2013

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The GlyT1 inhibitor RO4993850 alters social behaviour and ultrasonic vocalisation calls in a neonatal-phencyclidine isolation-reared rat model for schizophrenia

European neuropsychopharmacology, 2016-10, Vol.26, p.S494-S495

2016

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Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice

International Journal of Obesity, 2003-04, Vol.27 (4), p.433-442

2003

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Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.354-357

2006

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P.1.c.040 Partial occupancy of the glycine transporter type 1 by RG1678 leads to efficacy in animal models relevant to schizophrenia

European neuropsychopharmacology, 2011, Vol.21, p.S275-S276

2011

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P.3.e.009 Glycine reuptake inhibitor RG1678: results of the proof-of-concept study for the treatment of negative symptoms in schizophrenia

European neuropsychopharmacology, 2011, Vol.21, p.S517-S518

2011

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P.3.a.012 - The GlyT1 inhibitor RO4993850 alters social behaviour and ultrasonic vocalisation calls in a neonatal-phencyclidine isolation-reared rat model for schizophrenia

European neuropsychopharmacology, 2016-10, Vol.26, p.S494-S495

2016

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Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal–lesioned rats: reversal by glycine and a glycine transporter inhibitor

Biological psychiatry (1969), 2003-12, Vol.54 (11), p.1162-1170

2003

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Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells

The Journal of immunology (1950), 1997-07, Vol.159 (1), p.419-426

1997

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Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Neuroscience letters, 2005-01, Vol.373 (1), p.79-84

2005

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Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.349-353

2006

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Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4311-4315

2006

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Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators

Amino acids, 1998-01, Vol.14 (1-3), p.251-255

1998

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4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4321-4325

2006

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Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4305-4310

2006

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Regulation of the Kynurenine Metabolic Pathway by Interferon‐γ in Murine Cloned Macrophages and Microglial Cells

Journal of neurochemistry, 1996-03, Vol.66 (3), p.996-1004

1996

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Uncoupling protein 2 expression in hypothalamus of rodents during fever and in different metabolic conditions

Biochemical Society transactions, 2000-10, Vol.28 (5), p.A156-A156

2000

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Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells

Advances in experimental medicine and biology, 1996, Vol.398, p.171

1996

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Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney

The Journal of biological chemistry, 1995-12, Vol.270 (49), p.29330-29335

1995

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Molecular characterisation of kynurenine pathway enzymes. 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase

Advances in experimental medicine and biology, 1996, Vol.398, p.477

1996

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Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain

FEBS letters, 1995-06, Vol.367 (2), p.141-144

1995

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Cloning and functional expression of human kynurenine 3-monooxygenase

FEBS letters, 1997-06, Vol.410 (2), p.407-412

1997

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Cloning and Characterization of a Soluble Kynurenine Aminotransferase from Rat Brain: Identity with Kidney Cysteine Conjugate β‐Lyase

Journal of neurochemistry, 1995-04, Vol.64 (4), p.1448-1455

1995

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Isolation and Expression of a cDNA Clone Encoding Human Kynureninase

European journal of biochemistry, 1996-07, Vol.239 (2), p.460-468

1996

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OFQ knock-out mice: Behavioral phenotype seems to indicate homeostatic compensation of OFQ functional deficits

European neuropsychopharmacology, 1998-11, Vol.8, p.S310-S310

1998

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S.24.04 Glycine reuptake inhibitor bitopertin: characterisation in relation to symptom domains in schizophrenia

The GlyT1 inhibitor RO4993850 alters social behaviour and ultrasonic vocalisation calls in a neonatal-phencyclidine isolation-reared rat model for schizophrenia

Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice

Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile

P.1.c.040 Partial occupancy of the glycine transporter type 1 by RG1678 leads to efficacy in animal models relevant to schizophrenia

P.3.e.009 Glycine reuptake inhibitor RG1678: results of the proof-of-concept study for the treatment of negative symptoms in schizophrenia

P.3.a.012 - The GlyT1 inhibitor RO4993850 alters social behaviour and ultrasonic vocalisation calls in a neonatal-phencyclidine isolation-reared rat model for schizophrenia

Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal–lesioned rats: reversal by glycine and a glycine transporter inhibitor

Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators

4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Regulation of the Kynurenine Metabolic Pathway by Interferon‐γ in Murine Cloned Macrophages and Microglial Cells

Uncoupling protein 2 expression in hypothalamus of rodents during fever and in different metabolic conditions

Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells

Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney

Molecular characterisation of kynurenine pathway enzymes. 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase

Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain

Cloning and functional expression of human kynurenine 3-monooxygenase

Cloning and Characterization of a Soluble Kynurenine Aminotransferase from Rat Brain: Identity with Kidney Cysteine Conjugate β‐Lyase

Isolation and Expression of a cDNA Clone Encoding Human Kynureninase

OFQ knock-out mice: Behavioral phenotype seems to indicate homeostatic compensation of OFQ functional deficits

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