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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6801-6813

2018

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Oral enzyme therapy for maple syrup urine disease (MSUD) suppresses plasma leucine levels in intermediate MSUD mice and healthy nonhuman primates

Journal of inherited metabolic disease, 2023-11, Vol.46 (6), p.1089-1103

2023

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Optimizing human α-galactosidase for treatment of Fabry disease

Scientific reports, 2023-03, Vol.13 (1), p.4748-4748, Article 4748

2023

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Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Pharmaceutical research, 2017-11, Vol.34 (11), p.2403-2414

2017

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Design of second generation therapeutic recombinant bone morphogenetic proteins

Cytokine & growth factor reviews, 2009-10, Vol.20 (5), p.501-507

2009

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The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons

Stem cell research, 2018-04, Vol.28, p.105-114

2018

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In vitro treatment with liposome-encapsulated Mannose-1-phosphate restores N-glycosylation in PMM2-CDG patient-derived fibroblasts

Molecular genetics and metabolism, 2024-09, Vol.143 (1-2), p.108531, Article 108531

2024

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Liposome-encapsulated mannose-1-phosphate therapy improves global N-glycosylation in different congenital disorders of glycosylation

Molecular genetics and metabolism, 2024-06, Vol.142 (2), p.108487-108487, Article 108487

2024

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Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.12169-12180

2010

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Immunogenicity of bone morphogenetic proteins

Journal of neurosurgery. Spine, 2009-05, Vol.10 (5), p.443

2009

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P91. Identification of Cell Surface Receptors Mediating BMP-7 Induced Osteoblast Differentiation of Primary Human Mesenchymal Stem Cells

The spine journal, 2007, Vol.7 (5), p.124S-125S

2007

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An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract

Molecular genetics and metabolism, 2023-08, Vol.139 (4), p.107653-107653, Article 107653

2023

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Bioorganic & medicinal chemistry letters, 2023-06, Vol.89, p.129277-129277, Article 129277

2023

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New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells

Bone (New York, N.Y.), 2009-07, Vol.45 (1), p.27-41

2009

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A novel high throughput screening assay for HCV NS3 helicase activity

Antiviral research, 2000-06, Vol.46 (3), p.181-193

2000

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Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

The Journal of immunology (1950), 2017-05, Vol.198 (1_Supplement), p.217-217.4

2017

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Insect virus proteins (FALPE and p10) self-associate to form filaments in infected cells

Journal of Virology, 1998-03, Vol.72 (3), p.2213-2223

1998

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BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem CellsS

The Journal of biological chemistry, 2008-07, Vol.283 (30), p.20948-20958

2008

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Immunogenicity of osteogenic protein 1: results from a prospective, randomized, controlled, multicenter pivotal study of uninstrumented lumbar posterolateral fusion

Journal of neurosurgery. Spine, 2010-10, Vol.13 (4), p.484

2010

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Identification and characterization of a filament-associated protein encoded by Amsacta moorei entomopoxvirus

Journal of Virology, 1996-05, Vol.70 (5), p.2697-2705

1996

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Roles of three proline -rich proteins at late stages of entomopoxvirus and baculovirus morphogenesis

Alaoui Ismaili, Moulay Hicham

1999

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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Oral enzyme therapy for maple syrup urine disease (MSUD) suppresses plasma leucine levels in intermediate MSUD mice and healthy nonhuman primates

Optimizing human α-galactosidase for treatment of Fabry disease

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound

Design of second generation therapeutic recombinant bone morphogenetic proteins

The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons

In vitro treatment with liposome-encapsulated Mannose-1-phosphate restores N-glycosylation in PMM2-CDG patient-derived fibroblasts

Liposome-encapsulated mannose-1-phosphate therapy improves global N-glycosylation in different congenital disorders of glycosylation

Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity

Immunogenicity of bone morphogenetic proteins

P91. Identification of Cell Surface Receptors Mediating BMP-7 Induced Osteoblast Differentiation of Primary Human Mesenchymal Stem Cells

An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells

A novel high throughput screening assay for HCV NS3 helicase activity

Selective inhibition of NF-kB inducing kinase (NIK) is therapeutically efficacious in IFNα-accelerated lupus nephritis prone mice

Insect virus proteins (FALPE and p10) self-associate to form filaments in infected cells

BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem CellsS

Immunogenicity of osteogenic protein 1: results from a prospective, randomized, controlled, multicenter pivotal study of uninstrumented lumbar posterolateral fusion

Identification and characterization of a filament-associated protein encoded by Amsacta moorei entomopoxvirus

Roles of three proline -rich proteins at late stages of entomopoxvirus and baculovirus morphogenesis

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