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Mechanistic Modeling of SARS‐CoV‐2 and Other Infectious Diseases and the Effects of Therapeutics

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.829-840

2021

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Post-treatment control of HIV infection

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.5467-5472

2015

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Modeling the within-host dynamics of HIV infection

BMC biology, 2013-09, Vol.11 (1), p.96-96, Article 96

2013

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Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy

PLoS computational biology, 2009-10, Vol.5 (10), p.e1000533-e1000533

2009

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Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action

PLoS computational biology, 2021-03, Vol.17 (3), p.e1008752

2021

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Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (37), p.11654-11659

2015

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Modeling within-host dynamics of influenza virus infection including immune responses

PLoS computational biology, 2012-06, Vol.8 (6), p.e1002588-e1002588

2012

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Rapid emergence of protease inhibitor resistance in hepatitis C virus

Science translational medicine, 2010-05, Vol.2 (30), p.30ra32

2010

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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (6), p.2307-2312

2014

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Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3991-3996

2013

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A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

PLoS biology, 2021-03, Vol.19 (3), p.e3001128-e3001128

2021

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Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

CPT: pharmacometrics and systems pharmacology, 2020-09, Vol.9 (9), p.509-514

2020

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Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys

Cell, 2017-05, Vol.169 (4), p.610-620.e14

2017

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Stochastic theory of early viral infection: continuous versus burst production of virions

PLoS computational biology, 2011-02, Vol.7 (2), p.e1001058-e1001058

2011

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How robust are estimates of key parameters in standard viral dynamic models?

PLoS computational biology, 2024-04, Vol.20 (4), p.e1011437-e1011437

2024

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Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1

PLoS computational biology, 2024-03, Vol.20 (3), p.e1011518-e1011518

2024

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Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study

PLoS computational biology, 2014-04, Vol.10 (4), p.e1003568

2014

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Residual Viremia in Treated HIV+ Individuals

PLoS computational biology, 2016-01, Vol.12 (1), p.e1004677-e1004677

2016

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Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release

PLoS computational biology, 2020-11, Vol.16 (11), p.e1008421

2020

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A simple model of COVID-19 explains disease severity and the effect of treatments

Scientific reports, 2022-08, Vol.12 (1), p.14210-14210, Article 14210

2022

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Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response

Journal of the Royal Society interface, 2017-11, Vol.14 (136), p.20170479

2017

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Modeling Viral Spread

Annual review of virology, 2016-09, Vol.3 (1), p.555-572

2016

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Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers

PLoS computational biology, 2019-07, Vol.15 (7), p.e1007229-e1007229

2019

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Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

PLoS computational biology, 2023-04, Vol.19 (4), p.e1010423-e1010423

2023

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Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae

PLoS pathogens, 2013-03, Vol.9 (3), p.e1003238-e1003238

2013

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Mechanistic Modeling of SARS‐CoV‐2 and Other Infectious Diseases and the Effects of Therapeutics

Post-treatment control of HIV infection

Modeling the within-host dynamics of HIV infection

Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy

Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action

Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

Modeling within-host dynamics of influenza virus infection including immune responses

Rapid emergence of protease inhibitor resistance in hepatitis C virus

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys

Stochastic theory of early viral infection: continuous versus burst production of virions

How robust are estimates of key parameters in standard viral dynamic models?

Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1

Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study

Residual Viremia in Treated HIV+ Individuals

Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release

A simple model of COVID-19 explains disease severity and the effect of treatments

Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response

Modeling Viral Spread

Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers

Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae

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