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Metformin inhibits mTOR–HIF‐1α axis and profibrogenic and inflammatory biomarkers in thioacetamide‐induced hepatic tissue alterations

Journal of cellular physiology, 2019-06, Vol.234 (6), p.9328-9337

2019

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Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid‐19 pathology

Clinical and experimental pharmacology & physiology, 2022-04, Vol.49 (4), p.483-491

2022

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Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers

Clinical and experimental pharmacology & physiology, 2021-10, Vol.48 (10), p.1402-1411

2021

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Inhibition of GSK3β protects against collagen type II‐induced arthritis associated with a decrease in synovial leukocyte infiltration and inhibition of endoplasmic reticulum stress and autophagy biomarkers

Clinical and experimental pharmacology & physiology, 2020-08, Vol.47 (8), p.1393-1401

2020

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Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system

PloS one, 2012-01, Vol.7 (1), p.e28626-e28626

2012

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Negative regulation of soluble flt-1 and soluble endoglin release by heme oxygenase-1

Circulation (New York, N.Y.), 2007-04, Vol.115 (13), p.1789-1797

2007

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Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and â2

The Journal of physiology, 1999-06, Vol.517 (3), p.741-756

1999

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Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2756

2023

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The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

Nature communications, 2012-07, Vol.3 (1), p.972-972, Article 972

2012

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Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin

Drug and chemical toxicology (New York, N.Y. 1978), 2022-01, Vol.45 (1), p.1-7

2022

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Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta

American journal of obstetrics and gynecology, 2012-03, Vol.206 (3), p.253.e10-253.e15

2012

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Rat proteinase‐activated receptor‐2 (PAR‐2): cDNA sequence and activity of receptor‐derived peptides in gastric and vascular tissue

British journal of pharmacology, 1996-06, Vol.118 (3), p.521-530

1996

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Direct Evidence for Endothelial Vascular Endothelial Growth Factor Receptor-1 Function in Nitric Oxide–Mediated Angiogenesis

Circulation research, 2006-09, Vol.99 (7), p.715-722

2006

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MiR-155 Dysregulation Is Associated with the Augmentation of ROS/p53 Axis of Fibrosis in Thioacetamide-Induced Hepatotoxicity and Is Protected by Resveratrol

Diagnostics (Basel), 2022-07, Vol.12 (7), p.1762

2022

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Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury

Biomedicines, 2022-07, Vol.10 (7), p.1644

2022

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Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin-Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Biomedicines, 2022-04, Vol.10 (5), p.984

2022

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Vitamin E ameliorates alterations to the articular cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats

Ultrastructural pathology, 2019-05, Vol.43 (2-3), p.126-134

2019

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Lower Extremity Arterial Disease in Type 2 Diabetes Mellitus: Metformin Inhibits Femoral Artery Ultrastructural Alterations as well as Vascular Tissue Levels of AGEs/ET-1 Axis-Mediated Inflammation and Modulation of Vascular iNOS and eNOS Expression

Biomedicines, 2023-01, Vol.11 (2), p.361

2023

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Activation of Proteinase-Activated Receptor 2 Stimulates Soluble Vascular Endothelial Growth Factor Receptor 1 Release via Epidermal Growth Factor Receptor Transactivation in Endothelial Cells

Hypertension (Dallas, Tex. 1979), 2010-03, Vol.55 (3), p.689-697

2010

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Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis

Vascular cell, 2011-07, Vol.3 (1), p.15-15

2011

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Proteinase activated receptor 2: role of extracellular loop 2 for ligand‐mediated activation

British journal of pharmacology, 1999-11, Vol.128 (5), p.1105-1113

1999

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PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells

PloS one, 2012-08, Vol.7 (8), p.e43916-e43916

2012

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Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands

The Journal of pharmacology and experimental therapeutics, 1999-01, Vol.288 (1), p.358

1999

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VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways

Biochemical and biophysical research communications, 2006-07, Vol.345 (4), p.1275-1282

2006

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The release of nitric oxide from S-nitrosothiols promotes angiogenesis

PloS one, 2006-12, Vol.1 (1), p.e25-e25

2006

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Metformin inhibits mTOR–HIF‐1α axis and profibrogenic and inflammatory biomarkers in thioacetamide‐induced hepatic tissue alterations

Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid‐19 pathology

Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers

Inhibition of GSK3β protects against collagen type II‐induced arthritis associated with a decrease in synovial leukocyte infiltration and inhibition of endoplasmic reticulum stress and autophagy biomarkers

Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system

Negative regulation of soluble flt-1 and soluble endoglin release by heme oxygenase-1

Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and â2

Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin

Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta

Rat proteinase‐activated receptor‐2 (PAR‐2): cDNA sequence and activity of receptor‐derived peptides in gastric and vascular tissue

Direct Evidence for Endothelial Vascular Endothelial Growth Factor Receptor-1 Function in Nitric Oxide–Mediated Angiogenesis

MiR-155 Dysregulation Is Associated with the Augmentation of ROS/p53 Axis of Fibrosis in Thioacetamide-Induced Hepatotoxicity and Is Protected by Resveratrol

Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin-Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Vitamin E ameliorates alterations to the articular cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats

Lower Extremity Arterial Disease in Type 2 Diabetes Mellitus: Metformin Inhibits Femoral Artery Ultrastructural Alterations as well as Vascular Tissue Levels of AGEs/ET-1 Axis-Mediated Inflammation and Modulation of Vascular iNOS and eNOS Expression

Activation of Proteinase-Activated Receptor 2 Stimulates Soluble Vascular Endothelial Growth Factor Receptor 1 Release via Epidermal Growth Factor Receptor Transactivation in Endothelial Cells

Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis

Proteinase activated receptor 2: role of extracellular loop 2 for ligand‐mediated activation

PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells

Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands

VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways

The release of nitric oxide from S-nitrosothiols promotes angiogenesis

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