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Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

Journal of cellular physiology, 2014-08, Vol.229 (8), p.1096-1105

2014

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Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

Journal of neuroendocrinology, 2021-02, Vol.33 (2), p.e12931-n/a

2021

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An in vitro model of glucose transporter 1 deficiency syndrome at the blood–brain barrier using induced pluripotent stem cells

Journal of neurochemistry, 2022-09, Vol.162 (6), p.483-500

2022

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Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells

American Journal of Physiology: Cell Physiology, 2017-10, Vol.313 (4), p.C421-C429

Al-Ahmad, Abraham J

2017

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Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells

Fluids and barriers of the CNS, 2016-10, Vol.13 (1), p.16-16, Article 16

2016

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Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro

Fluids and barriers of the CNS, 2021-01, Vol.18 (1), p.3-3, Article 3

2021

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Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

The Journal of clinical investigation, 2011-08, Vol.121 (8), p.3005-3023

2011

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Modeling the blood-brain barrier using stem cell sources

Fluids and barriers of the CNS, 2013-01, Vol.10 (1), p.2-2, Article 2

2013

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Perlecan domain V modulates astrogliosis In vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release

Glia, 2011-12, Vol.59 (12), p.1822-1840

2011

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Quercetin and naringenin transport across human intestinal Caco-2 cells

Journal of pharmacy and pharmacology, 2009-11, Vol.61 (11), p.1473-1483

2009

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Human-Induced Pluripotent Stem Cell-Based Model of the Blood-Brain at 10 Years: A Retrospective on Past and Current Disease Models

Human iPSC-derived Disease Models for Drug Discovery, 2023, p.141-156

2023

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Isogenic blood–brain barrier models based on patient‐derived stem cells display inter‐individual differences in cell maturation and functionality

Journal of neurochemistry, 2017-07, Vol.142 (1), p.74-88

2017

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Assessing the effects of COVID‐19‐induced hypoxia and ACE2 signaling on the human blood‐brain barrier in‐vitro

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Ketone bodies supplementation restores the barrier function, induces a metabolic switch, and elicits beta-hydroxybutyrate diffusion across a monolayer of iPSC-derived brain microvascular endothelial cells

Microvascular research, 2023-11, Vol.150, p.104585-104585, Article 104585

2023

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Abeta peptides disrupt the barrier integrity and glucose metabolism of human induced pluripotent stem cell-derived brain microvascular endothelial cells

Neurotoxicology (Park Forest South), 2022-03, Vol.89, p.110-120

2022

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Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Nature biotechnology, 2012-08, Vol.30 (8), p.783-791

2012

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Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway

Journal of cerebral blood flow and metabolism, 2019-09, Vol.39 (9), p.1759-1775

2019

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Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood–Brain Barrier is Partially Mediated Through the HIF-1 Pathway

Neuromolecular medicine, 2019-12, Vol.21 (4), p.414-431

2019

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Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier

Cell stem cell, 2017-06, Vol.20 (6), p.831-843.e5

2017

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CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

Drug discovery today, 2020-02, Vol.25 (2), p.456-465

2020

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Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult

Journal of cerebral blood flow and metabolism, 2011-02, Vol.31 (2), p.693-705

2011

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Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling

Stem cell reports, 2014-11, Vol.3 (5), p.804-816

2014

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αB-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain

Clinical cancer research, 2014, Vol.20 (1), p.56-67

2014

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LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

Fluids and barriers of the CNS, 2020-10, Vol.17 (1), p.1-15, Article 61

2020

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Comment on "Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines"

The Journal of immunology (1950), 2024-03, Vol.212 (5), p.753-753

Al-Ahmad, Abraham

2024

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Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

An in vitro model of glucose transporter 1 deficiency syndrome at the blood–brain barrier using induced pluripotent stem cells

Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells

Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells

Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

Modeling the blood-brain barrier using stem cell sources

Perlecan domain V modulates astrogliosis In vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release

Quercetin and naringenin transport across human intestinal Caco-2 cells

Human-Induced Pluripotent Stem Cell-Based Model of the Blood-Brain at 10 Years: A Retrospective on Past and Current Disease Models

Isogenic blood–brain barrier models based on patient‐derived stem cells display inter‐individual differences in cell maturation and functionality

Assessing the effects of COVID‐19‐induced hypoxia and ACE2 signaling on the human blood‐brain barrier in‐vitro

Ketone bodies supplementation restores the barrier function, induces a metabolic switch, and elicits beta-hydroxybutyrate diffusion across a monolayer of iPSC-derived brain microvascular endothelial cells

Abeta peptides disrupt the barrier integrity and glucose metabolism of human induced pluripotent stem cell-derived brain microvascular endothelial cells

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway

Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood–Brain Barrier is Partially Mediated Through the HIF-1 Pathway

Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier

CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult

Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling

αB-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain

LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

Comment on "Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines"

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