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The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

Expert opinion on therapeutic targets, 2017-12, Vol.21 (12), p.1171-1177

2017

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SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

Frontiers in cellular and infection microbiology, 2021-07, Vol.11, p.701278-701278

2021

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Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

Nature communications, 2020-05, Vol.11 (1), p.2280-2280, Article 2280

2020

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Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Theranostics, 2021-01, Vol.11 (16), p.8076-8091

2021

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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.E3187-E3195

2014

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Human CD59 Inhibitor Sensitizes Rituximab-Resistant Lymphoma Cells to Complement-Mediated Cytolysis

Cancer research (Chicago, Ill.), 2011-03, Vol.71 (6), p.2298-2307

2011

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Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9457-9470

2013

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Messenger RNA Translation Defects in Neurodegenerative Diseases

The New England journal of medicine, 2023-06, Vol.388 (22), p.2110-2111

2023

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Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors

European journal of medicinal chemistry, 2014-04, Vol.77, p.361-377

2014

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The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

Stem cells international, 2019-01, Vol.2019 (2019), p.1-20

2019

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Dual Activators of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

Chembiochem : a European journal of chemical biology, 2013-07, Vol.14 (10), p.1255-1262

2013

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Small-Molecule targeting of translation initiation for cancer therapy

Oncotarget, 2013-10, Vol.4 (10), p.1606-1617

2013

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Restriction of drug transport by the tumor environment

Histochemistry and cell biology, 2018-12, Vol.150 (6), p.631-648

2018

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Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129119-129119, Article 129119

2023

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Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27Kip1

The Journal of biological chemistry, 2010-05, Vol.285 (20), p.15408-15419

2010

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New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties

European journal of medicinal chemistry, 2020-02, Vol.187, p.111973, Article 111973

2020

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Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

Nature chemical biology, 2011-09, Vol.7 (9), p.610-616

2011

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Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5094-5111

2014

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Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

Scientific reports, 2017-12, Vol.7 (1), p.17074-11, Article 17074

2017

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Development of 1‑((1,4-trans)‑4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5392-5406

2017

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In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.402-409

2012

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Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

Oncotarget, 2015-03, Vol.6 (9), p.6902-6914

2015

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3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction

Chembiochem : a European journal of chemical biology, 2014-03, Vol.15 (4), p.595-611

2014

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Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

European journal of medicinal chemistry, 2013-11, Vol.69, p.537-553

2013

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Abstract PR12: Targeting eIF2α phosphorylation for cancer therapy

Cancer research (Chicago, Ill.), 2017-03, Vol.77 (6_Supplement), p.PR12-PR12

2017

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The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Human CD59 Inhibitor Sensitizes Rituximab-Resistant Lymphoma Cells to Complement-Mediated Cytolysis

Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

Messenger RNA Translation Defects in Neurodegenerative Diseases

Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors

The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

Dual Activators of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

Small-Molecule targeting of translation initiation for cancer therapy

Restriction of drug transport by the tumor environment

Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27Kip1

New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

Development of 1‑((1,4-trans)‑4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

Abstract PR12: Targeting eIF2α phosphorylation for cancer therapy

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