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Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2022-03, Vol.28 (3), p.377-383

2022

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Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Thrombosis journal, 2020-06, Vol.18 (1), p.10-9, Article 10

2020

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Sensory evaluation of edoxaban orally disintegrating tablets: an open-label interventional study (secondary publication)

Thrombosis journal, 2019-02, Vol.17 (1), p.3-3, Article 3

2019

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Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance

Antimicrobial Agents and Chemotherapy, 2001-08, Vol.45 (8), p.2263-2268

2001

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First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan

International journal of antimicrobial agents, 2007-06, Vol.29 (6), p.738-739

2007

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Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain

Journal of palliative medicine, 2023-06, Vol.26 (6), p.768

2023

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In Vitro and In Vivo Antibacterial Activities of DK-507k, a Novel Fluoroquinolone

Antimicrobial Agents and Chemotherapy, 2003-12, Vol.47 (12), p.3750-3759

2003

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Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetic Kidney Disease: A Multicenter, Open-Label, Prospective Study

Advances in therapy, 2022-11, Vol.39 (11), p.5158-5175

2022

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Rationale and Design of the Efficacy and Safety of Esaxerenone in Hypertensive Patients With Left Ventricular Hypertrophy (ESES-LVH) Study　― Protocol for a Multicenter, Open-Label, Exploratory Interventional Study

Circulation Reports, 2022/02/10, Vol.4(2), pp.99-104

2022

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In Vitro Antibacterial Activities of DQ-113, a Potent Quinolone, against Clinical Isolates

Antimicrobial Agents and Chemotherapy, 2002-03, Vol.46 (3), p.904-908

2002

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Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

Antimicrobial Agents and Chemotherapy, 1998-05, Vol.42 (5), p.1284-1287

1998

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InVitro and In Vivo Antibacterial Activities of DK-507k, aNovelFluoroquinolone

Antimicrobial agents and chemotherapy, 2003-12, Vol.47 (12), p.3750-3759

2003

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Cloning, Expression, and Enzymatic Characterization of Pseudomonas aeruginosaTopoisomerase IV

Antimicrobial Agents and Chemotherapy, 1999-03, Vol.43 (3), p.530-536

1999

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Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV

Antimicrobial agents and chemotherapy, 1999-03, Vol.43 (3), p.530-536

1999

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Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene

Antimicrobial Agents and Chemotherapy, 1996-03, Vol.40 (3), p.710-714

1996

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Rationale and Design of the Efficacy and Safety of Esaxerenone in Hypertensive Patients With Left Ventricular Hypertrophy (ESES-LVH) Study　― Protocol for a Multicenter, Open-Label, Exploratory Interventional Study

Circulation Reports, 2022/01/20, pp.CR-21-0122

2022

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Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. Roles of the aspartyl residues located in the putative transmembrane helices

The Journal of biological chemistry, 1992-04, Vol.267 (11), p.7490-7498

1992

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Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6045-6051

1991

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Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli

The Journal of biological chemistry, 1993-12, Vol.268 (36), p.26990-26995

1993

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Serine residues responsible for tetracycline transport are on a vertical stripe including Asp-84 on one side of transmembrane helix 3 in transposon Tn10-encoded tetracycline/H + antiporter of Escherichia coli

FEBS letters, 1992-07, Vol.307 (2), p.229-232

1992

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Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli

Biochemistry (Easton), 1993-06, Vol.32 (21), p.5698

1993

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Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/hydrogen ion antiporter of Escherichia coli

Biochemistry (Easton), 1993-06, Vol.32 (21), p.5698-5704

1993

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Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Scientific reports, 2024-03, Vol.14 (1), p.7374-7374

2024

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Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study

Diabetes care, 2018-06, Vol.41 (6), p.1275-1284

2018

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Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains

Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Sensory evaluation of edoxaban orally disintegrating tablets: an open-label interventional study (secondary publication)

Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance

First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan

Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain

In Vitro and In Vivo Antibacterial Activities of DK-507k, a Novel Fluoroquinolone

Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetic Kidney Disease: A Multicenter, Open-Label, Prospective Study

Rationale and Design of the Efficacy and Safety of Esaxerenone in Hypertensive Patients With Left Ventricular Hypertrophy (ESES-LVH) Study　― Protocol for a Multicenter, Open-Label, Exploratory Interventional Study

In Vitro Antibacterial Activities of DQ-113, a Potent Quinolone, against Clinical Isolates

Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

InVitro and In Vivo Antibacterial Activities of DK-507k, aNovelFluoroquinolone

Cloning, Expression, and Enzymatic Characterization of Pseudomonas aeruginosaTopoisomerase IV

Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV

Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene

Rationale and Design of the Efficacy and Safety of Esaxerenone in Hypertensive Patients With Left Ventricular Hypertrophy (ESES-LVH) Study　― Protocol for a Multicenter, Open-Label, Exploratory Interventional Study

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. Roles of the aspartyl residues located in the putative transmembrane helices

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation

Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli

Serine residues responsible for tetracycline transport are on a vertical stripe including Asp-84 on one side of transmembrane helix 3 in transposon Tn10-encoded tetracycline/H + antiporter of Escherichia coli

Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli

Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/hydrogen ion antiporter of Escherichia coli

Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome: The STOPDAPT-2 ACS Randomized Clinical Trial

Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study

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