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Disease Modeling and Drug Development for Parkinson’s Disease Using iPS Cells

Japanese Journal of Psychosomatic Medicine, 2023, Vol.63(4), pp.317-320

Akamatsu, Wado

2023

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Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (25), p.E5815-E5823

2018

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Increased l1 retrotransposition in the neuronal genome in schizophrenia

Neuron (Cambridge, Mass.), 2014-01, Vol.81 (2), p.306-313

2014

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Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development

Nature communications, 2020-04, Vol.11 (1), p.1674-21, Article 1674

2020

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Modeling Neurological Diseases with Induced Pluripotent Stem Cells

Juntendo Iji Zasshi = Juntendo Medical Journal, 2018, Vol.64 (6), p.450-453

AKAMATSU, WADO

2018

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Variants in saposin D domain of prosaposin gene linked to Parkinson's disease

Brain (London, England : 1878), 2020-04, Vol.143 (4), p.1190-1205

2020

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Neuroprotective effects of memantine via enhancement of autophagy

Biochemical and biophysical research communications, 2019-10, Vol.518 (1), p.161-170

2019

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BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model

Journal of neurochemistry, 2020-10, Vol.155 (1), p.81-97

2020

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Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication

Stem cell research, 2024-06, Vol.77, p.103401, Article 103401

2024

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Regeneration of the damaged central nervous system through reprogramming technology: Basic concepts and potential application for cell replacement therapy

Experimental neurology, 2014-10, Vol.260, p.12-18

2014

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Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation

Stem cell research, 2024-04, Vol.76, p.103323-103323, Article 103323

2024

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Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons

Biochemical and biophysical research communications, 2017-01, Vol.483 (1), p.88-93

2017

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CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

eLife, 2017-11, Vol.6

2017

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Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes

Stem cell research, 2024-02, Vol.74, p.103271-103271, Article 103271

2024

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Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Stem cell research, 2024-02, Vol.74, p.103270-103270, Article 103270

2024

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Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells

Stem cell reports, 2017-11, Vol.9 (5), p.1675-1691

2017

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Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease

PloS one, 2024-08, Vol.19 (8), p.e0291887

2024

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Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes

Stem cell reports, 2015-12, Vol.5 (6), p.1010-1022

2015

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Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Disease Modeling

Juntendo Iji Zasshi = Juntendo Medical Journal, 2017, Vol.63 (1), p.37-41

AKAMATSU, WADO

2017

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In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells

Scientific reports, 2021-07, Vol.11 (1), p.15437-15437, Article 15437

2021

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Systemic Metabolic Alteration Dependent on the Thyroid‐Liver Axis in Early PD

Annals of neurology, 2023-02, Vol.93 (2), p.303-316

2023

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Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity

Cancer science, 2022-10, Vol.113 (10), p.3449-3462

2022

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Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

Stem cell reports, 2020-06, Vol.14 (6), p.1060-1075

2020

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Neural Stem Cells Directly Differentiated from Partially Reprogrammed Fibroblasts Rapidly Acquire Gliogenic Competency

Stem cells (Dayton, Ohio), 2012-06, Vol.30 (6), p.1109-1119

2012

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Generation of three clones (JUCGRMi002-A, B, C) of induced pluripotent stem cells from a Parkinson’s disease patient with SNCA duplication

Stem cell research, 2024-02, Vol.74, p.103296-103296, Article 103296

2024

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Disease Modeling and Drug Development for Parkinson’s Disease Using iPS Cells

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

Increased l1 retrotransposition in the neuronal genome in schizophrenia

Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development

Modeling Neurological Diseases with Induced Pluripotent Stem Cells

Variants in saposin D domain of prosaposin gene linked to Parkinson's disease

Neuroprotective effects of memantine via enhancement of autophagy

BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model

Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication

Regeneration of the damaged central nervous system through reprogramming technology: Basic concepts and potential application for cell replacement therapy

Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation

Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes

Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells

Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes

Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Disease Modeling

In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells

Systemic Metabolic Alteration Dependent on the Thyroid‐Liver Axis in Early PD

Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity

Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease

Neural Stem Cells Directly Differentiated from Partially Reprogrammed Fibroblasts Rapidly Acquire Gliogenic Competency

Generation of three clones (JUCGRMi002-A, B, C) of induced pluripotent stem cells from a Parkinson’s disease patient with SNCA duplication

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