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Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Lab on a chip, 2019-09, Vol.19 (19), p.3152-3161

2019

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Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

Neurochemistry international, 2016-10, Vol.99, p.72-84

2016

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Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies

Journal of inherited metabolic disease, 2018-07, Vol.41 (4), p.699-708

2018

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Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial

Critical care (London, England), 2009-01, Vol.13 (3), p.R75-R75

2009

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Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis

Toxicological sciences, 2013-03, Vol.132 (1), p.53-63

2013

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Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

The Journal of pharmacology and experimental therapeutics, 2015-03, Vol.352 (3), p.462

2015

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In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

PloS one, 2017-10, Vol.12 (10), p.e0186919-e0186919

2017

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mTOR Inhibition Mitigates Molecular and Biochemical Alterations of Vigabatrin-Induced Visual Field Toxicity in Mice

Pediatric neurology, 2017-01, Vol.66, p.44-52.e1

2017

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Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin‐associated ocular toxicity?

Clinical pharmacology and therapeutics, 2017-04, Vol.101 (4), p.458-461

2017

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Does the efficacy of neurodynamic treatments depend on the presence and type of criteria used to define neural mechanosensitivity in spinally-referred leg pain? A systematic review and meta-analysis

The South African journal of physiotherapy, 2022, Vol.78 (1), p.1627-1627

2022

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Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder

Toxicology in vitro, 2018-02, Vol.46, p.203-212

2018

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Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Biochimica et biophysica acta. Molecular basis of disease, 2017-01, Vol.1863 (1), p.33-42

2017

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Comparison of boiling and chlorination on the quality of stored drinking water and childhood diarrhoea in Indonesian households

Epidemiology and infection, 2017-11, Vol.145 (15), p.3294-3302

2017

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In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding

Toxicology in vitro, 2017-04, Vol.40, p.196-202

2017

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Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Pharmacology research & perspectives, 2019-02, Vol.7 (1), p.e00456-n/a

2019

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Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies

Clinical and translational science, 2017-09, Vol.10 (5), p.380-386

2017

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mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Journal of inherited metabolic disease, 2016-11, Vol.39 (6), p.877-886

2016

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Microbiologic effectiveness of boiling and safe water storage in South Sulawesi, Indonesia

Journal of water and health, 2011-09, Vol.9 (3), p.577-585

2011

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Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues

Neurochemistry international, 2019-05, Vol.125, p.151-162

2019

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Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice

Molecular genetics and metabolism reports, 2015-06, Vol.3 (C), p.80-87

2015

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Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates

The Journal of pharmacology and experimental therapeutics, 2014-12, Vol.351 (3), p.576

2014

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Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity

Journal of pharmaceutical and biomedical analysis, 2014-09, Vol.98, p.260-265

2014

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A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication

Pharmacology research & perspectives, 2016-12, Vol.4 (6), p.e00265-n/a

2016

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Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug

Drug metabolism and disposition, 2013-02, Vol.41 (2), p.518

2013

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Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids

Molecular genetics and metabolism reports, 2017-06, Vol.11 (C), p.81-89

2017

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Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies

Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

mTOR Inhibition Mitigates Molecular and Biochemical Alterations of Vigabatrin-Induced Visual Field Toxicity in Mice

Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin‐associated ocular toxicity?

Does the efficacy of neurodynamic treatments depend on the presence and type of criteria used to define neural mechanosensitivity in spinally-referred leg pain? A systematic review and meta-analysis

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Comparison of boiling and chlorination on the quality of stored drinking water and childhood diarrhoea in Indonesian households

In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies

mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Microbiologic effectiveness of boiling and safe water storage in South Sulawesi, Indonesia

Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues

Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice

Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates

Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity

A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication

Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug

Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids

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