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Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

Nature communications, 2014-08, Vol.5 (1), p.4589-4589, Article 4589

2014

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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

Journal of medicinal chemistry, 2014-04, Vol.57 (7), p.3040-3052

2014

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Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization

Molecular pharmacology, 2009-10, Vol.76 (4), p.833-842

2009

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Hydrophobic Residues in Helix 8 of Cannabinoid Receptor 1 Are Critical for Structural and Functional Properties

Biochemistry (Easton), 2010-01, Vol.49 (3), p.502-511

2010

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Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation

The Journal of biological chemistry, 2012-04, Vol.287 (15), p.12070-12082

2012

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Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9790-9800

2013

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Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor

Molecular pharmacology, 2016-06, Vol.89 (6), p.618-629

2016

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Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor

European journal of medicinal chemistry, 2016-10, Vol.121, p.517-529

2016

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Structure–Activity Relationship in the Leucettine Family of Kinase Inhibitors

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1396-1417

2022

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Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi

The Journal of biological chemistry, 2013-11, Vol.288 (45), p.32449

2013

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Structure–Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1)

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.7965-7975

2013

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Profiling two indole‐2‐carboxamides for allosteric modulation of the CB1 receptor

Journal of neurochemistry, 2013-03, Vol.124 (5), p.584-589

2013

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cannabinoid type-1 receptor carboxyl-terminus, more than just a tail

Journal of neurochemistry, 2011-04, Vol.117 (1), p.1-18

2011

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Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding

Proteins, structure, function, and bioinformatics, 2013-08, Vol.81 (8), p.1304-1317

2013

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Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations

Protein science, 2013-01, Vol.22 (1), p.101-113

2013

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Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor

Journal of chemical information and modeling, 2016-01, Vol.56 (1), p.201-212

2016

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Mutations of CB1 T210 Produce Active and Inactive Receptor Forms: Correlations with Ligand Affinity, Receptor Stability, and Cellular Localization

Biochemistry (Easton), 2006-05, Vol.45 (17), p.5606-5617

2006

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Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices

Biopolymers, 2009-07, Vol.91 (7), p.565-573

2009

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A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation

Brain research, 2006-09, Vol.1108 (1), p.1-11

2006

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Molecular Basis of Cannabinoid CB1 Receptor Coupling to the G Protein Heterotrimer Gαiβγ

The Journal of biological chemistry, 2013-11, Vol.288 (45), p.32449-32465

2013

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Molecular Basis of Cannabinoid CB1 Receptor Coupling to the G Protein Heterotrimer Gαiβγ: IDENTIFICATION OF KEY CB1 CONTACTS WITH THE C-TERMINAL HELIX α

The Journal of biological chemistry, 2013-10, Vol.288 (45), p.32449-32465

2013

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Structural basis of human cannabinoid CB1 G protein‐coupled receptor activation

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Profiling two indole‐2‐carboxamides for allosteric modulation of the CB 1 receptor

Journal of neurochemistry, 2013-03, Vol.124 (5), p.584-589

2013

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Mutations of CB 1 T210 Produce Active and Inactive Receptor Forms: Correlations with Ligand Affinity, Receptor Stability, and Cellular Localization

Biochemistry (Easton), 2006-05, Vol.45 (17), p.5606-5617

2006

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Settling and dewatering characteristics of mixed microorganisms according to changes in the SRT

Desalination and water treatment, 2013-09, Vol.51 (31-33), p.6201-6209

2013

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Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization

Hydrophobic Residues in Helix 8 of Cannabinoid Receptor 1 Are Critical for Structural and Functional Properties

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor

Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor

Structure–Activity Relationship in the Leucettine Family of Kinase Inhibitors

Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi

Structure–Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1)

Profiling two indole‐2‐carboxamides for allosteric modulation of the CB1 receptor

cannabinoid type-1 receptor carboxyl-terminus, more than just a tail

Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations

Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor

Mutations of CB1 T210 Produce Active and Inactive Receptor Forms: Correlations with Ligand Affinity, Receptor Stability, and Cellular Localization

Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation

Molecular Basis of Cannabinoid CB1 Receptor Coupling to the G Protein Heterotrimer Gαiβγ

Molecular Basis of Cannabinoid CB1 Receptor Coupling to the G Protein Heterotrimer Gαiβγ: IDENTIFICATION OF KEY CB1 CONTACTS WITH THE C-TERMINAL HELIX α

Structural basis of human cannabinoid CB1 G protein‐coupled receptor activation

Profiling two indole‐2‐carboxamides for allosteric modulation of the CB 1 receptor

Mutations of CB 1 T210 Produce Active and Inactive Receptor Forms: Correlations with Ligand Affinity, Receptor Stability, and Cellular Localization

Settling and dewatering characteristics of mixed microorganisms according to changes in the SRT

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