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Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

Experimental and Molecular Medicine, 2020, 52(0), , pp.1-10

2020

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eNEMAL, an enhancer RNA transcribed from a distal MALAT1 enhancer, promotes NEAT1 long isoform expression

PloS one, 2021-05, Vol.16 (5), p.e0251515-e0251515

2021

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SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Nature communications, 2021-09, Vol.12 (1), p.5551-5551, Article 5551

2021

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SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

Molecular cell, 2016-03, Vol.61 (6), p.859-873

2016

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FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation

Scientific reports, 2019-05, Vol.9 (1), p.7617-7617, Article 7617

2019

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Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

The Journal of biological chemistry, 2013-03, Vol.288 (13), p.9165-9176

2013

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Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription

Circulation research, 2019-07, Vol.125 (2), p.152-166

2019

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son is necessary for proper vertebrate blood development

PloS one, 2021-02, Vol.16 (2), p.e0247489-e0247489

2021

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SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia

Cancer gene therapy, 2021-09, Vol.28 (9), p.1000-1015

2021

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Establishing the phenotypic spectrum of ZTTK syndrome by analysis of 52 individuals with variants in SON

European journal of human genetics : EJHG, 2022-03, Vol.30 (3), p.271-281

2022

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New Discoveries of Old SON: A Link Between RNA Splicing and Cancer

Journal of cellular biochemistry, 2014-02, Vol.115 (2), p.224-231

2014

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DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

Oncotarget, 2018-08, Vol.9 (60), p.31719-31743

2018

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Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation

Inflammation, 2021-06, Vol.44 (3), p.1130-1144

2021

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FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation

Cardiovascular research, 2022-03, Vol.118 (4), p.1150-1163

2022

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Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.987-992

2019

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Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells

The Journal of biological chemistry, 2019-07, Vol.294 (29), p.11213-11224

2019

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Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.102013-102013, Article 102013

2022

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FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Circulation research, 2021-12, Vol.129 (12), p.e215-e233

2021

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Nuclear FAK in endothelium: An intrinsic inhibitor of NF-κB activation in atherosclerosis

Atherosclerosis, 2023-08, Vol.379, p.117189-117189, Article 117189

2023

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FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression

Biochemical and biophysical research communications, 2019-02, Vol.509 (4), p.1034-1040

2019

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SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes

Kidney international, 2019-06, Vol.95 (6), p.1494-1504

2019

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miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

Oncotarget, 2016-11, Vol.7 (48), p.78667-78679

2016

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Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model

Oncotarget, 2018-05, Vol.9 (34), p.23532-23542

2018

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Transcript variants of RUNX1T1: New insight into t(8;21)-positive leukemia

Leukemia research, 2014-09, Vol.38 (9), p.1018-1019

2014

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Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

eNEMAL, an enhancer RNA transcribed from a distal MALAT1 enhancer, promotes NEAT1 long isoform expression

SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription

son is necessary for proper vertebrate blood development

SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia

Establishing the phenotypic spectrum of ZTTK syndrome by analysis of 52 individuals with variants in SON

New Discoveries of Old SON: A Link Between RNA Splicing and Cancer

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation

FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation

Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells

Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation

FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Nuclear FAK in endothelium: An intrinsic inhibitor of NF-κB activation in atherosclerosis

FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression

SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes

miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model

A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis

Transcript variants of RUNX1T1: New insight into t(8;21)-positive leukemia

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