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Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6203

2022

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New quinoxaline-2(1)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations

New journal of chemistry, 2021-09, Vol.45 (36), p.16949-16964

2021

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Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.1884-1902

2022

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Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.1389-1403

2022

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Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS

Molecules (Basel, Switzerland), 2022-12, Vol.27 (24), p.8809

2022

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Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.2206-2222

2022

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Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

Scientific reports, 2020-03, Vol.10 (1), p.4736, Article 4736

2020

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Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations

Molecules (Basel, Switzerland), 2022-08, Vol.27 (17), p.5571

2022

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Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4079

2022

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Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h -TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.577

2021

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Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs

International journal of pharmaceutics, 2007-08, Vol.340 (1), p.126-133

2007

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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation

Molecules (Basel, Switzerland), 2022-08, Vol.27 (15), p.5047

2022

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Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico , In Vitro , and SAR Studies

Frontiers in chemistry, 2021-09, Vol.9, p.725135

2021

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Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.640-658

2021

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Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management

Molecules (Basel, Switzerland), 2022-06, Vol.27 (11), p.3584

2022

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In Utero Heat Stress Alters the Offspring Epigenome

Scientific reports, 2018-10, Vol.8 (1), p.14609-15, Article 14609

2018

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Design, synthesis, docking study and anticancer evaluation of new trimethoxyphenyl pyridine derivatives as tubulin inhibitors and apoptosis inducers

RSC advances, 2021-12, Vol.11 (63), p.39728-39741

2021

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Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.573-591

2022

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Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression

International journal of molecular sciences, 2023-07, Vol.24 (14), p.11816

2023

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A Novel Trinuclear Nickel(II) Salicylaldimine Complex: Synthesis, Structural Characterization, Bioactivity Profile against Bacterial, Fungal and Breast Cancer Cells and Effects on Wheat Germination Indices

Crystals (Basel), 2023-07, Vol.13 (7), p.1084

2023

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Zn(II) and Cd(II) thiosemicarbazones for stimulation/inhibition of kojic acid biosynthesis from Aspergillus flavus and the fungal defense behavior against the metal complexes' excesses

Journal of biological inorganic chemistry, 2020-08, Vol.25 (5), p.797-809

2020

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Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives

Anti-cancer agents in medicinal chemistry, 2017-01, Vol.17 (10), p.1389

2017

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Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors

Archiv der Pharmazie (Weinheim), 2019-11, Vol.352 (11), p.e1900123-n/a

2019

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Synthesis, Solid State Structure, and Cytotoxic Activity of a Complex Dimer of Yttrium with Anthranilic Acid against Cancer Cells

Biological trace element research, 2023-10, Vol.201 (10), p.4688-4696

2023

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Occupational ocular health problems among marble workers at Shaq El Tho’ban industrial area in Egypt

Environmental science and pollution research international, 2022-05, Vol.29 (25), p.37445-37457

2022

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Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

New quinoxaline-2(1)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors

Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs

Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico , In Vitro , and SAR Studies

Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management

In Utero Heat Stress Alters the Offspring Epigenome

Design, synthesis, docking study and anticancer evaluation of new trimethoxyphenyl pyridine derivatives as tubulin inhibitors and apoptosis inducers

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression

A Novel Trinuclear Nickel(II) Salicylaldimine Complex: Synthesis, Structural Characterization, Bioactivity Profile against Bacterial, Fungal and Breast Cancer Cells and Effects on Wheat Germination Indices

Zn(II) and Cd(II) thiosemicarbazones for stimulation/inhibition of kojic acid biosynthesis from Aspergillus flavus and the fungal defense behavior against the metal complexes' excesses

Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives

Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors

Synthesis, Solid State Structure, and Cytotoxic Activity of a Complex Dimer of Yttrium with Anthranilic Acid against Cancer Cells

Occupational ocular health problems among marble workers at Shaq El Tho’ban industrial area in Egypt

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