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40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors

Neuropsychopharmacology (New York, N.Y.), 2016-08, Vol.41 (9), p.2232-2240

2016

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Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays

Journal of neurophysiology, 2016-06, Vol.115 (6), p.3217-3228

2016

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A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

Alzheimer's & dementia : translational research & clinical interventions, 2018, Vol.4 (1), p.746-755

2018

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NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

Frontiers in psychiatry, 2014-08, Vol.5, p.96-96

2014

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APP Processing Is Regulated by Cytoplasmic Phosphorylation

The Journal of cell biology, 2003-10, Vol.163 (1), p.83-95

2003

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Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in duchenne muscular dystrophy patients and in dystrophin deficient rodents

Neuromuscular disorders : NMD, 2017-07, Vol.27 (7), p.635-645

2017

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Exploring the Therapeutic Potential of Phosphorylated Cis -Tau Antibody in a Pig Model of Traumatic Brain Injury

Biomedicines, 2023-06, Vol.11 (7), p.1807

2023

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Hyperphosphorylated Tau and Neurofilament and Cytoskeletal Disruptions in Mice Overexpressing Human p25, an Activator of cdk5

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (6), p.2910-2915

2000

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Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau

Alzheimer's & dementia, 2023-10, Vol.19 (10), p.4662-4674

2023

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Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5521-5525

2004

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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.138

2016

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Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127530, Article 127530

2020

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A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

Molecular pharmacology, 2017-09, Vol.92 (3), p.310-317

2017

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Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β

Alzheimer's research & therapy, 2014-01, Vol.6 (2), p.14-14

2014

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Tau transgenic mice as models for cerebrospinal fluid tau biomarkers

Journal of Alzheimer's disease, 2011-01, Vol.24 Suppl 2, p.127

2011

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Partial Rescue of the p35-/- Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene

The Journal of neuroscience, 2003-04, Vol.23 (7), p.2769-2778

2003

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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.125

2016

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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators

European journal of pharmacology, 2017-10, Vol.812, p.104-112

2017

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Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5729-5731

2016

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A Functional Na V 1.7-Na V Ab Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

Molecular pharmacology, 2017-09, Vol.92 (3), p.310-317

2017

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B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor

European journal of pharmacology, 2017-03, Vol.799, p.16-25

2017

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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.271-276

2016

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.312-317

2019

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Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseases

Analytical methods, 2017-06, Vol.9 (23), p.3477-3484

2017

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40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors

Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays

A randomized, single ascending dose study of intravenous BIIB092 in healthy participants

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation

APP Processing Is Regulated by Cytoplasmic Phosphorylation

Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in duchenne muscular dystrophy patients and in dystrophin deficient rodents

Exploring the Therapeutic Potential of Phosphorylated Cis -Tau Antibody in a Pig Model of Traumatic Brain Injury

Hyperphosphorylated Tau and Neurofilament and Cytoskeletal Disruptions in Mice Overexpressing Human p25, an Activator of cdk5

Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β

Tau transgenic mice as models for cerebrospinal fluid tau biomarkers

Partial Rescue of the p35-/- Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

A Functional Na V 1.7-Na V Ab Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseases

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