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Strategies for designing and optimizing new generation vaccines

Nature reviews. Immunology, 2001-12, Vol.1 (3), p.209-219

2001

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Interplay of Cytokines and Adjuvants in the Regulation of Mucosal and Systemic HIV-Specific CTL

The Journal of immunology (1950), 2000-12, Vol.165 (11), p.6454-6462

2000

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Mechanisms of cytokine synergy essential for vaccine protection against viral challenge

International immunology, 2001-07, Vol.13 (7), p.897-908

2001

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Simultaneous approach using systemic, mucosal and transcutaneous routes of immunization for development of protective HIV-1 vaccines

Current medicinal chemistry, 2011-09, Vol.18 (26), p.3953-3962

2011

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Shared Modes of Protection against Poxvirus Infection by Attenuated and Conventional Smallpox Vaccine Viruses

Proceedings of the National Academy of Sciences - PNAS, 2003-08, Vol.100 (16), p.9458-9463

2003

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Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

Nature medicine, 2001-12, Vol.7 (12), p.1320-1326

2001

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A Push-Pull Approach to Maximize Vaccine Efficacy: Abrogating Suppression with an IL-13 Inhibitor While Augmenting Help with Granulocyte/Macrophage Colony-Stimulating Factor and CD40L

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (20), p.13020-13025

2002

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Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC

The Journal of immunology (1950), 2003-03, Vol.170 (5), p.2523-2530

2003

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Mucosal Immunization with HIV-1 Peptide Vaccine Induces Mucosal and Systemic Cytotoxic T Lymphocytes and Protective Immunity in Mice against Intrarectal Recombinant HIV-Vaccinia Challenge

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1709-1714

1998

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High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

The Journal of clinical investigation, 2001-12, Vol.108 (11), p.1677-1685

2001

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Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose

International immunology, 2001-11, Vol.13 (11), p.1433-1442

2001

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Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule

The Journal of immunology (1950), 1995-02, Vol.154 (4), p.1973-1986

1995

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The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12

The Journal of clinical investigation, 1998-12, Vol.102 (12), p.2072-2081

1998

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Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization

AIDS research and human retroviruses, 1996-03, Vol.12 (4), p.259-272

1996

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Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

Journal of Virology, 1998-10, Vol.72 (10), p.8264-8272

1998

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Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations

The Journal of immunology (1950), 1993-06, Vol.150 (12), p.5647-5665

1993

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Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes

The Journal of immunology (1950), 1997-04, Vol.158 (8), p.3947-3958

1997

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Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections

Immunological reviews, 1999-08, Vol.170 (1), p.151-172

1999

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A Model for CD8+ CTL Tumor Immunosurveillance and Regulation of Tumor Escape by CD4 T Cells Through an Effect on Quality of CTL

The Journal of immunology (1950), 1999-07, Vol.163 (1), p.184-193

1999

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Role of 3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs

International immunology, 2007-12, Vol.19 (12), p.1413-1420

2007

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Enhanced Immunogenicity of HIV-1 Vaccine Construct by Modification of the Native Peptide Sequence

Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (20), p.10856-10861

1997

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Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion

European journal of immunology, 2001-12, Vol.31 (12), p.3557-3566

2001

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Functional CD8 super(+) CTLs in mucosal sites and HIV infection: moving forward toward a mucosal AIDS vaccine

Trends in immunology, 2008-11, Vol.29 (11), p.574-585

2008

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Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells

The Journal of clinical investigation, 2004-04, Vol.113 (7), p.998-1007

2004

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Progress on new vaccine strategies for the immunotherapy and prevention of cancer

The Journal of clinical investigation, 2004-06, Vol.113 (11), p.1515-1525

2004

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Strategies for designing and optimizing new generation vaccines

Interplay of Cytokines and Adjuvants in the Regulation of Mucosal and Systemic HIV-Specific CTL

Mechanisms of cytokine synergy essential for vaccine protection against viral challenge

Simultaneous approach using systemic, mucosal and transcutaneous routes of immunization for development of protective HIV-1 vaccines

Shared Modes of Protection against Poxvirus Infection by Attenuated and Conventional Smallpox Vaccine Viruses

Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

A Push-Pull Approach to Maximize Vaccine Efficacy: Abrogating Suppression with an IL-13 Inhibitor While Augmenting Help with Granulocyte/Macrophage Colony-Stimulating Factor and CD40L

Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC

Mucosal Immunization with HIV-1 Peptide Vaccine Induces Mucosal and Systemic Cytotoxic T Lymphocytes and Protective Immunity in Mice against Intrarectal Recombinant HIV-Vaccinia Challenge

High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose

Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule

The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12

Candidate HIV type 1 multideterminant cluster peptide-P18MN vaccine constructs elicit type 1 helper T cells, cytotoxic T cells, and neutralizing antibody, all using the same adjuvant immunization

Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations

Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes

Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections

A Model for CD8+ CTL Tumor Immunosurveillance and Regulation of Tumor Escape by CD4 T Cells Through an Effect on Quality of CTL

Role of 3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs

Enhanced Immunogenicity of HIV-1 Vaccine Construct by Modification of the Native Peptide Sequence

Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion

Functional CD8 super(+) CTLs in mucosal sites and HIV infection: moving forward toward a mucosal AIDS vaccine

Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells

Progress on new vaccine strategies for the immunotherapy and prevention of cancer

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