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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage
Cancer cell, 2021-02, Vol.39 (2), p.209-224.e11
2021
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A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury
PloS one, 2015-06, Vol.10 (6), p.e0127175-e0127175
2015
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Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
PloS one, 2012-03, Vol.7 (3), p.e33258
2012
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Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis
Hepatology (Baltimore, Md.), 2012-11, Vol.56 (5), p.1861-1869
2012
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miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target
PloS one, 2012-09, Vol.7 (9), p.e44305-e44305
2012
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Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial
JAMA oncology, 2021-11, Vol.7 (11), p.1669
2021
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Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study
The lancet. Gastroenterology & hepatology, 2019-09, Vol.4 (9), p.711-720
2019
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Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner
Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3510-3510
2019
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Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant- IDH1 cholangiocarcinoma
Future oncology (London, England), 2021-06, Vol.17 (16), p.2057-2074
2021
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HIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p
Scientific reports, 2017-01, Vol.7 (1), p.41099-41099, Article 41099
2017
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Abstract 2714: Targeting MAT2A in CDKN2A/MTAP-deleted cancers
Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2714-2714
2019
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Abstract B115: Mitotic defects induced by MAT2A inhibitors guides translational drug combination strategies with AG-270 and taxanes
Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.B115-B115
2019
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The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines
Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (28), p.14039-14048
2019
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Abstract 3090: The MAT2A inhibitor, AG-270, combines with both taxanes and gemcitabine to yield enhanced anti-tumor activity in patient-derived xenograft models
Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3090-3090
2020
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Abstract B169: Retrospective baseline biomarker analyses in a first-in-human Phase 1 trial of the PKMYT1 inhibitor lunresertib (RP-6306) in pts with advanced solid tumors harboring CCNE1 amplification and/or deleterious alterations in FBXW7 or PPP2R1A
Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B169-B169
2023
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Abstract 2132: Tumor heterogeneity of CCNE1 copy number assessed by fluorescence in situ hybridization (FISH) in ovarian and uterine cancers and correlation with cyclin E protein expression
Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2132-2132
2023
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Abstract PR03: A phase 1 trial of AG-270 in patients with advanced solid tumors or lymphoma with homozygous MTAP deletion
Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.PR03-PR03
2019
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Abstract B057: Preclinical development of PKMYT1 and ATR inhibitor combinations
Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B057-B057
2023
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Abstract C163: KRAS alterations combined with TP53 mutations as novel synthetic lethal genomic lesions for PKMYT1 inhibition
Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.C163-C163
2023
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Abstract PR008: MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with CCNE1 amplification or deleterious alterations in FBXW7 or PPP2R1A
Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.PR008-PR008
2023
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MicroRNAs in the kidney: novel biomarkers of acute kidney injury
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2013-01, Vol.33 (6), p.826-834
2013
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HIF-1[alpha] induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p
Scientific reports, 2017-01, Vol.7, p.41099
2017
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Differential resolution of inflammation and recovery after renal ischemia–reperfusion injury in Brown Norway compared with Sprague Dawley rats
Kidney international, 2010-05, Vol.77 (9), p.781-793
2010
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Hypoxia Inducible Factor 1-Alpha
PloS one, 2012-03, Vol.7 (3), p.e33258
2012
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