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IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics

Scientific reports, 2023-03, Vol.13 (1), p.4791-4791, Article 4791

2023

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Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Scientific reports, 2022-06, Vol.12 (1), p.9321-9321, Article 9321

2022

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Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

Journal of pharmaceutical sciences, 2012-01, Vol.101 (1), p.102-115

2012

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Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

Journal of pharmaceutical sciences, 2011-12, Vol.100 (12), p.5081-5095

2011

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Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab

mAbs, 2016-01, Vol.8 (1), p.99-112

2016

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Prediction of the Hydrogen Peroxide–Induced Methionine Oxidation Propensity in Monoclonal Antibodies

Journal of pharmaceutical sciences, 2018-05, Vol.107 (5), p.1282-1289

2018

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Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity

Frontiers in immunology, 2020-05, Vol.11, p.832

2020

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Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis

PLoS computational biology, 2010-09, Vol.6 (9), p.e1000926

2010

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Heterogeneity in Disulfide Bond Reduction in IgG1 Antibodies Is Governed by Solvent Accessibility of the Cysteines

Antibodies (Basel), 2023-12, Vol.12 (4), p.83

2023

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Multivalent Binding of Nanocarrier to Endothelial Cells under Shear Flow

Biophysical journal, 2011-07, Vol.101 (2), p.319-326

2011

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Utilizing cross-product prior knowledge to rapidly de-risk chemical liabilities in therapeutic antibody candidates

AAPS open, 2022-05, Vol.8 (1), p.1-9, Article 10

2022

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Computational methods to predict therapeutic protein aggregation

Methods in molecular biology (Clifton, N.J.), 2012, Vol.899, p.425

2012

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Tryptophan Oxidation of a Monoclonal Antibody Under Diverse Oxidative Stress Conditions: Distinct Oxidative Pathways Favor Specific Tryptophan Residues

Journal of pharmaceutical sciences, 2021-02, Vol.110 (2), p.719-726

2021

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Effects of Buffer Composition on Site-Specific Glycation of Lysine Residues in Monoclonal Antibodies

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.293-300

2020

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Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody

Biotechnology and bioengineering, 2018-12, Vol.115 (12), p.2930-2940

2018

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Computational tool for the early screening of monoclonal antibodies for their viscosities

mAbs, 2016-01, Vol.8 (1), p.43-48

2016

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A computational tool to predict the evolutionarily conserved protein–protein interaction hot-spot residues from the structure of the unbound protein

FEBS letters, 2014-01, Vol.588 (2), p.326-333

2014

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Fast and scalable purification of a therapeutic full-length antibody based on process crystallization

Biotechnology and bioengineering, 2013-09, Vol.110 (9), p.2452-2461

2013

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The Role of Glycocalyx in Nanocarrier-Cell Adhesion Investigated Using a Thermodynamic Model and Monte Carlo Simulations

Journal of physical chemistry. C, 2007-11, Vol.111 (43), p.15848-15856

2007

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Systems biology and physical biology of clathrin-mediated endocytosis

Integrative biology (Cambridge), 2011-08, Vol.3 (8), p.803-815

2011

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A flexible-protein molecular docking study of the binding of ruthenium complex compounds to PIM1, GSK-3β, and CDK2/Cyclin A protein kinases

Journal of molecular modeling, 2013-01, Vol.19 (1), p.371-382

2013

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Mesoscale simulations of curvature-inducing protein partitioning on lipid bilayer membranes in the presence of mean curvature fields

Molecular physics, 2012-06, Vol.110 (11-12), p.1127-1137

2012

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Calculation of free energies in fluid membranes subject to heterogeneous curvature fields

Physical review. E, Statistical, nonlinear, and soft matter physics, 2009-07, Vol.80 (1 Pt 1), p.011925-011925, Article 011925

2009

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Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model

Molecular physics, 2008-08, Vol.106 (15), p.1913-1923

2008

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Geometry of Mediating Protein Affects the Probability of Loop Formation in DNA

Biophysical journal, 2008-04, Vol.94 (8), p.3150-3158

2008

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IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab

Prediction of the Hydrogen Peroxide–Induced Methionine Oxidation Propensity in Monoclonal Antibodies

Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity

Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis

Heterogeneity in Disulfide Bond Reduction in IgG1 Antibodies Is Governed by Solvent Accessibility of the Cysteines

Multivalent Binding of Nanocarrier to Endothelial Cells under Shear Flow

Utilizing cross-product prior knowledge to rapidly de-risk chemical liabilities in therapeutic antibody candidates

Computational methods to predict therapeutic protein aggregation

Tryptophan Oxidation of a Monoclonal Antibody Under Diverse Oxidative Stress Conditions: Distinct Oxidative Pathways Favor Specific Tryptophan Residues

Effects of Buffer Composition on Site-Specific Glycation of Lysine Residues in Monoclonal Antibodies

Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody

Computational tool for the early screening of monoclonal antibodies for their viscosities

A computational tool to predict the evolutionarily conserved protein–protein interaction hot-spot residues from the structure of the unbound protein

Fast and scalable purification of a therapeutic full-length antibody based on process crystallization

The Role of Glycocalyx in Nanocarrier-Cell Adhesion Investigated Using a Thermodynamic Model and Monte Carlo Simulations

Systems biology and physical biology of clathrin-mediated endocytosis

A flexible-protein molecular docking study of the binding of ruthenium complex compounds to PIM1, GSK-3β, and CDK2/Cyclin A protein kinases

Mesoscale simulations of curvature-inducing protein partitioning on lipid bilayer membranes in the presence of mean curvature fields

Calculation of free energies in fluid membranes subject to heterogeneous curvature fields

Landscape of finite-temperature equilibrium behaviour of curvature-inducing proteins on a bilayer membrane explored using a linearized elastic free energy model

Geometry of Mediating Protein Affects the Probability of Loop Formation in DNA

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