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ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function

Progress in retinal and eye research, 2019-03, Vol.69, p.137-158

2019

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Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4

Journal of lipid research, 2021-01, Vol.62, p.100030, Article 100030

2021

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Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans

Advances in experimental medicine and biology, 2016-01, Vol.854, p.129-135

2016

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Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy‐like retinal degeneration in a mouse model with iron overload

Aging cell, 2022-04, Vol.21 (4), p.e13579-n/a

2022

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Emerging insights into the function of very long chain fatty acids at cerebellar synapses

Neural regeneration research, 2025-06, Vol.20 (6), p.1709-1710

2025

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Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

Journal of lipid research, 2023-05, Vol.64 (5), p.100358, Article 100358

2023

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ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis

Journal of lipid research, 2023-01, Vol.64 (1), p.100317, Article 100317

2023

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A Bietti Crystalline Dystrophy Mouse Model Shows Increased Sensitivity to Light-Induced Injury

International journal of molecular sciences, 2022-11, Vol.23 (21), p.13108

2022

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Obesity promotes lipid accumulation in mouse cartilage—A potential role of acetyl‐CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis

Journal of orthopaedic research, 2022-12, Vol.40 (12), p.2771-2779

2022

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Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint

Journal of lipid research, 2017-04, Vol.58 (4), p.668-680

2017

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Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse

PloS one, 2018-01, Vol.13 (1), p.e0190514

2018

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Pharmacokinetics and metabolism in mouse retina of bis-allylic deuterated docosahexaenoic acid (D-DHA), a new dry AMD drug candidate

Experimental eye research, 2022-09, Vol.222, p.109193-109193, Article 109193

2022

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Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors

Journal of lipid research, 2018-09, Vol.59 (9), p.1586-1596

2018

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W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34

Molecular neurobiology, 2021-10, Vol.58 (10), p.4921-4943

2021

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A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report

Acta neuropathologica communications, 2023-08, Vol.11 (1), p.131-131, Article 131

2023

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Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

Journal of lipid research, 2010-07, Vol.51 (7), p.1624-1642

2010

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Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (35), p.12843-12848

2008

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Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro

Free radical biology & medicine, 2007-06, Vol.42 (12), p.1838-1850

2007

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Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality

Journal of assisted reproduction and genetics, 2019-07, Vol.36 (7), p.1379-1385

2019

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Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis

Antioxidants, 2023-07, Vol.12 (7), p.1385

2023

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The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration

Molecular neurobiology, 2020-11, Vol.57 (11), p.4735-4753

2020

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Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

eLife, 2020-12, Vol.9

2020

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Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency

Molecular neurobiology, 2018-02, Vol.55 (2), p.1795-1813

2018

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Curcumin protects retinal cells from light-and oxidant stress-induced cell death

Free radical biology & medicine, 2009-03, Vol.46 (5), p.672-679

2009

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Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress

Journal of neurochemistry, 2016-03, Vol.136 (5), p.931-946

2016

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ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4

Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans

Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy‐like retinal degeneration in a mouse model with iron overload

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis

A Bietti Crystalline Dystrophy Mouse Model Shows Increased Sensitivity to Light-Induced Injury

Obesity promotes lipid accumulation in mouse cartilage—A potential role of acetyl‐CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis

Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse

Pharmacokinetics and metabolism in mouse retina of bis-allylic deuterated docosahexaenoic acid (D-DHA), a new dry AMD drug candidate

Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors

W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34

A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report

Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro

Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality

Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency

Curcumin protects retinal cells from light-and oxidant stress-induced cell death

Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress

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