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Gene silencing by CRISPR interference in mycobacteria

Nature communications, 2015-02, Vol.6 (1), p.6267-6267, Article 6267

2015

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Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis

Frontiers in cellular and infection microbiology, 2019-03, Vol.9, p.70-70

2019

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Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

Nature (London), 2009-07, Vol.460 (7251), p.98-102

2009

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HtpG Is a Metal-Dependent Chaperone Which Assists the DnaK/DnaJ/GrpE Chaperone System of Mycobacterium tuberculosis via Direct Association with DnaJ2

Microbiology spectrum, 2023-06, Vol.11 (3), p.e0031223-e0031223

2023

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Discovery of potent antimycobacterial agents targeting lumazine synthase (RibH) of Mycobacterium tuberculosis

Scientific reports, 2024-05, Vol.14 (1), p.12170-12170, Article 12170

2024

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De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation

Communications biology, 2021-03, Vol.4 (1), p.410-410, Article 410

2021

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Expression of a subset of heat stress induced genes of mycobacterium tuberculosis is regulated by 3',5'-cyclic AMP

PloS one, 2014-02, Vol.9 (2), p.e89759-e89759

2014

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Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus

Scientific reports, 2022-08, Vol.12 (1), p.13801-13801, Article 13801

2022

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Construction of a novel CRISPRi-based tool for silencing of multiple genes in Mycobacterium tuberculosis

Plasmid, 2020-07, Vol.110, p.102515-102515, Article 102515

Agarwal, Nisheeth

2020

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Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments

PloS one, 2012-07, Vol.7 (7), p.e37516-e37516

2012

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Designing a Cas9/gRNA-assisted quantitative Real-Time PCR (CARP) assay for identification of point mutations leading to rifampicin resistance in the human pathogen Mycobacterium tuberculosis

Gene, 2023-03, Vol.857, p.147173-147173, Article 147173

2023

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Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes

Antimicrobial Agents and Chemotherapy, 2006-08, Vol.50 (8), p.2836-2841

2006

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Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation

Results in Chemistry, 2023-01, Vol.5, p.100904, Article 100904

2023

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Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

Communications biology, 2024-08, Vol.7 (1), p.949-12, Article 949

2024

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Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model

PloS one, 2012-02, Vol.7 (2), p.e30749-e30749

2012

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Functional characterization of EngA(MS), a P-loop GTPase of Mycobacterium smegmatis

PloS one, 2012, Vol.7 (4), p.e34571-e34571

2012

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ResR/McdR-regulated protein translation machinery contributes to drug resilience in Mycobacterium tuberculosis

Communications biology, 2023-07, Vol.6 (1), p.708-708, Article 708

2023

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Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria

ACS central science, 2019-04, Vol.5 (4), p.644-650

2019

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Functional Characterization of EngAMS, a P-Loop GTPase of Mycobacterium smegmatis

PloS one, 2012-04, Vol.7 (4), p.e34571

2012

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History, evolution and classification of CRISPR-Cas associated systems

Progress in molecular biology and translational science, 2021, Vol.179, p.11-76

2021

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Characterization of the Mycobacterium tuberculosis Sigma Factor SigM by Assessment of Virulence and Identification of SigM-Dependent Genes

Infection and Immunity, 2007-01, Vol.75 (1), p.452-461

2007

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Japanese encephalitis virus hijacks ER-associated degradation regulators for its replication

Journal of general virology, 2024-05, Vol.105 (5)

2024

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The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini

The Journal of biological chemistry, 2020-07, Vol.295 (28), p.9455-9473

2020

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Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy- d -xylulose 5-phosphate reductoisomerase (DXR): in silico , in vitro and antibacterial studies

RSC advances, 2024-08, Vol.14 (38), p.27530-27554

2024

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Proteomic Landscape of a Drug-Tolerant Persister Subpopulation of Mycobacterium tuberculosis

Journal of proteome research, 2021-09, Vol.20 (9), p.4415-4426

2021

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Gene silencing by CRISPR interference in mycobacteria

Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis

Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

HtpG Is a Metal-Dependent Chaperone Which Assists the DnaK/DnaJ/GrpE Chaperone System of Mycobacterium tuberculosis via Direct Association with DnaJ2

Discovery of potent antimycobacterial agents targeting lumazine synthase (RibH) of Mycobacterium tuberculosis

De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation

Expression of a subset of heat stress induced genes of mycobacterium tuberculosis is regulated by 3',5'-cyclic AMP

Identification of small molecules targeting homoserine acetyl transferase from Mycobacterium tuberculosis and Staphylococcus aureus

Construction of a novel CRISPRi-based tool for silencing of multiple genes in Mycobacterium tuberculosis

Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments

Designing a Cas9/gRNA-assisted quantitative Real-Time PCR (CARP) assay for identification of point mutations leading to rifampicin resistance in the human pathogen Mycobacterium tuberculosis

Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes

Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model

Functional characterization of EngA(MS), a P-loop GTPase of Mycobacterium smegmatis

ResR/McdR-regulated protein translation machinery contributes to drug resilience in Mycobacterium tuberculosis

Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria

Functional Characterization of EngAMS, a P-Loop GTPase of Mycobacterium smegmatis

History, evolution and classification of CRISPR-Cas associated systems

Characterization of the Mycobacterium tuberculosis Sigma Factor SigM by Assessment of Virulence and Identification of SigM-Dependent Genes

Japanese encephalitis virus hijacks ER-associated degradation regulators for its replication

The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini

Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy- d -xylulose 5-phosphate reductoisomerase (DXR): in silico , in vitro and antibacterial studies

Proteomic Landscape of a Drug-Tolerant Persister Subpopulation of Mycobacterium tuberculosis

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