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A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

Toxicological sciences, 2013-11, Vol.136 (1), p.216-241

2013

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

Molecular pharmacology, 2002-01, Vol.61 (1), p.1-6

2002

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BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (17), p.9587-9592

2001

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Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats

PloS one, 2014-02, Vol.9 (2), p.e88750-e88750

2014

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Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers

Toxicologic pathology, 2005-01, Vol.33 (3), p.343-355

2005

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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

Toxicological sciences, 2010-12, Vol.118 (2), p.485-500

2010

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The evolution of bioinformatics in toxicology: advancing toxicogenomics

Toxicological sciences, 2011-03, Vol.120 Suppl 1 (Supplement 1), p.S225-S237

2011

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Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Bone (New York, N.Y.), 2016-03, Vol.84, p.148-159

2016

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Short-Chain Fatty Acids Enhance Nuclear Receptor Activity through Mitogen-Activated Protein Kinase Activation and Histone Deacetylase Inhibition

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (18), p.7199-7204

2004

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A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity

PloS one, 2010-12, Vol.5 (12), p.e15595-e15595

2010

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Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression

Molecular biology of the cell, 2002-08, Vol.13 (8), p.2585-2597

2002

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Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations

Toxicologic pathology, 2002-07, Vol.30 (4), p.470-482

2002

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Mot1 Activates and Represses Transcription by Direct, ATPase-Dependent Mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (5), p.2666-2671

2002

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Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

Toxicologic pathology, 2015-06, Vol.43 (4), p.581-592

2015

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Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

American journal of physiology. Heart and circulatory physiology, 2003-01, Vol.284 (1), p.H268-H276

2003

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Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment

Environmental health perspectives, 2004-03, Vol.112 (4), p.460-464

2004

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Assessment of repeated microarray experiments using mixed tissue RNA reference samples

BioTechniques, 2008-09, Vol.45 (3), p.283-292

2008

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Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs

Toxicological sciences, 2015-06, Vol.145 (2), p.283-295

2015

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Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen

Molecular endocrinology (Baltimore, Md.), 2003-10, Vol.17 (10), p.2070-2083

2003

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A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells

Toxicological sciences, 2014-11, Vol.142 (1), p.261-273

2014

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Gene Expression Analysis Reveals Chemical-Specific Profiles

Toxicological sciences, 2002-06, Vol.67 (2), p.219-231

2002

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Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program

Cancer cell, 2004-03, Vol.5 (3), p.263-273

2004

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Microarrays and toxicology: The advent of toxicogenomics

Molecular carcinogenesis, 1999-03, Vol.24 (3), p.153-159

1999

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Perspective: Microarray Technology, Seeing More Than Spots

Endocrinology (Philadelphia), 2002-06, Vol.143 (6), p.1983-1989

Afshari, Cynthia A

2002

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Prediction of Compound Signature Using High Density Gene Expression Profiling

Toxicological sciences, 2002-06, Vol.67 (2), p.232-240

2002

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A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats

Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

The evolution of bioinformatics in toxicology: advancing toxicogenomics

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Short-Chain Fatty Acids Enhance Nuclear Receptor Activity through Mitogen-Activated Protein Kinase Activation and Histone Deacetylase Inhibition

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity

Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression

Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations

Mot1 Activates and Represses Transcription by Direct, ATPase-Dependent Mechanisms

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment

Assessment of repeated microarray experiments using mixed tissue RNA reference samples

Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs

Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen

A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells

Gene Expression Analysis Reveals Chemical-Specific Profiles

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program

Microarrays and toxicology: The advent of toxicogenomics

Perspective: Microarray Technology, Seeing More Than Spots

Prediction of Compound Signature Using High Density Gene Expression Profiling

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