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Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Journal of the American Chemical Society, 2019-03, Vol.141 (10), p.4214-4218

2019

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Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome

PloS one, 2012-10, Vol.7 (10), p.e47805-e47805

2012

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Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

PloS one, 2017-07, Vol.12 (7), p.e0182075-e0182075

2017

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Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

PloS one, 2016-01, Vol.11 (1), p.e0147208-e0147208

2016

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Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

PloS one, 2009-03, Vol.4 (3), p.e4723-e4723

2009

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Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases

Genetics (Austin), 2007-10, Vol.177 (2), p.959-970

2007

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a-Synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy

PloS one, 2023-02, Vol.18 (2), p.e0277602-e0277602

2023

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Glycosphingolipids-Nature, Function, and Pharmacological Modulation

Angewandte Chemie (International ed.), 2009-11, Vol.48 (47), p.8848-8869

2009

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Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

Chemical science (Cambridge), 2023-08, Vol.14 (34), p.9136-9144

2023

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Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle

PloS one, 2011-01, Vol.6 (1), p.e14503-e14503

2011

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The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe

Organic & biomolecular chemistry, 2023-10, Vol.21 (38), p.7813-782

2023

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Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

PloS one, 2015-08, Vol.10 (8), p.e0135889-e0135889

2015

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Spiro‐epoxyglycosides as Activity‐Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase

Chemistry : a European journal, 2018-07, Vol.24 (39), p.9983-9992

2018

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Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards

PloS one, 2015-10, Vol.10 (10), p.e0140097-e0140097

2015

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Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

PloS one, 2015-09, Vol.10 (9), p.e0138107-e0138107

2015

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The Unique Phenotype of Lipid-Laden Macrophages

International journal of molecular sciences, 2021-04, Vol.22 (8), p.4039

2021

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Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

PloS one, 2012-10, Vol.7 (10), p.e38520

2012

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Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention

Blood, 2004-01, Vol.103 (1), p.33-39

2004

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Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

Frontiers in plant science, 2020-04, Vol.11, p.357-357

2020

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Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies

Journal of inherited metabolic disease, 2011-06, Vol.34 (3), p.605-619

2011

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Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

PloS one, 2017-02, Vol.12 (2), p.e0170268-e0170268

2017

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Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

Hepatology (Baltimore, Md.), 2009-11, Vol.50 (5), p.1431-1441

2009

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Real‐Time NMR Recording of Fermentation and Lipid Metabolism Processes in Live Microalgae Cells

Angewandte Chemie (International ed.), 2022-03, Vol.61 (14), p.e202117521-n/a

International ed. in English, 2022

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Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease

PloS one, 2011-06, Vol.6 (6), p.e21758-e21758

2011

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Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man

Journal of organic chemistry, 2007-02, Vol.72 (4), p.1088-1097

2007

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Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome

Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases

a-Synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy

Glycosphingolipids-Nature, Function, and Pharmacological Modulation

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle

The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

Spiro‐epoxyglycosides as Activity‐Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase

Accuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

The Unique Phenotype of Lipid-Laden Macrophages

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention

Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

Real‐Time NMR Recording of Fermentation and Lipid Metabolism Processes in Live Microalgae Cells

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease

Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man

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