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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809-817

2008

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L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2252-2260

2008

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148-1155

2009

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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1095-1101

2007

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Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2468-2474

2008

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Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Expert opinion on drug discovery, 2018-09, Vol.13 (9), p.815-824

2018

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In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2036-2043

2006

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Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.185-191

2003

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Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.513-524

2017

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Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs

Biochemical pharmacology, 2007-06, Vol.73 (11), p.1829-1841

2007

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Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1163-1172

2003

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Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Toxicology (Amsterdam), 2013-04, Vol.306, p.157-161

2013

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2600-2607

2012

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Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1‑Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells

Chemical research in toxicology, 2017-02, Vol.30 (2), p.552-563

2017

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Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Chemical research in toxicology, 2016-06, Vol.29 (6), p.1041-1050

2016

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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.77-86

2002

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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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Reduction of l-methionine selenoxide to seleno- l-methionine by endogenous thiols, ascorbic acid, or methimazole

Biochemical pharmacology, 2009-01, Vol.77 (1), p.134-140

2009

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Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

Chemico-biological interactions, 2015-01, Vol.226, p.40-48

2015

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Globin Monoadducts and Cross-Links Provide Evidence for the Presence of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide, Chlorothioketene, and 2-Chlorothionoacetyl Chloride in the Circulation in Rats Administered S-(1,2-Dichlorovinyl)-l-cysteine

Chemical research in toxicology, 2009-09, Vol.22 (9), p.1629-1638

2009

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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Expert opinion on drug metabolism & toxicology, 2010-11, Vol.6 (11), p.1333-1346

2010

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Formation of Mono- and Bis-Michael Adducts by the Reaction of Nucleophilic Amino Acids with Hydroxymethylvinyl Ketone, a Reactive Metabolite of 1,3-Butadiene

Chemical research in toxicology, 2009-05, Vol.22 (5), p.918-925

2009

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Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

Toxicology and applied pharmacology, 2013-02, Vol.267 (1), p.1-10

2013

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Formation of Fused-Ring 2′-Deoxycytidine Adducts from 1‑Chloro-3-buten-2-one, an in Vitro 1,3-Butadiene Metabolite, under in Vitro Physiological Conditions

Chemical research in toxicology, 2013-10, Vol.26 (10), p.1545-1553

2013

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs

Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1‑Chloro-2-hydroxy-3-butene to 1‑Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

Characterization of the Major Purine and Pyrimidine Adducts Formed after Incubations of 1‑Chloro-3-buten-2-one with Single-/Double-Stranded DNA and Human Cells

Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1‑Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Role of reactive metabolites in the circulation in extrahepatic toxicity

Reduction of l-methionine selenoxide to seleno- l-methionine by endogenous thiols, ascorbic acid, or methimazole

Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2′-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity

Globin Monoadducts and Cross-Links Provide Evidence for the Presence of S-(1,2-Dichlorovinyl)-l-cysteine Sulfoxide, Chlorothioketene, and 2-Chlorothionoacetyl Chloride in the Circulation in Rats Administered S-(1,2-Dichlorovinyl)-l-cysteine

The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Formation of Mono- and Bis-Michael Adducts by the Reaction of Nucleophilic Amino Acids with Hydroxymethylvinyl Ketone, a Reactive Metabolite of 1,3-Butadiene

Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

Formation of Fused-Ring 2′-Deoxycytidine Adducts from 1‑Chloro-3-buten-2-one, an in Vitro 1,3-Butadiene Metabolite, under in Vitro Physiological Conditions

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