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MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis

Expert opinion on investigational drugs, 2018-07, Vol.27 (7), p.631-636

2018

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Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1)

The Journal of pharmacology and experimental therapeutics, 2010-09, Vol.334 (3), p.936

2010

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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

Bioorganic & medicinal chemistry, 2018-12, Vol.26 (22), p.5870-5884

2018

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Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans

Critical care medicine, 1996-05, Vol.24 (5), p.756-764

1996

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Journal of medicinal chemistry, 2003-01, Vol.46 (2), p.284-302

2003

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Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents

Pharmaceutical research, 2003-08, Vol.20 (8), p.1149-1155

2003

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New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4209-4212

2003

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Stereochemistry of the Carbonyl Reduction of MSDC‐0602, An mTOT‐modulating Insulin‐sensitizer for the Treatment of Nonalcoholic Steatohepatitis (NASH)

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4235-4239

2003

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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3769-3789

1996

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Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Journal of medicinal chemistry, 1998-12, Vol.41 (26), p.5144-5147

1998

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Excretion mass balance and quantitative whole‐body autoradiography following a single oral (PO) administration of [14C]MSDC 0602, an mTOT‐modulating insulin sensitizer, in Sprague Dawley (SD) and Long‐Evans (LE) rats

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs

Journal of medicinal chemistry, 1996-12, Vol.39 (26), p.5267-5275

1996

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Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors: Effect of 3-Alkylpyridine Ring Substitution

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4140-4149

1999

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Structure, equilibrium conformation, and pseudorotation in cyclopentane. An electron diffraction study

Journal of the American Chemical Society, 1970-08, Vol.92 (17), p.5013-5019

1970

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Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575)

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.49

2004

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Pharmacokinetics and systemic bioavailability of menogaril, and anthracycline antitumor agent, in the mouse, dog, and monkey

Cancer research (Chicago, Ill.), 1989-11, Vol.49 (22), p.6328-6336

1989

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Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection

Analytical chemistry (Washington), 1984-08, Vol.56 (9), p.1587-1590

1984

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Liquid chromatographic determination of guanadrel in laboratory animal diet as the fluorescent acetylacetone derivative

Analytical chemistry (Washington), 1982-06, Vol.54 (7), p.1087-1090

1982

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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones: Antibacterial agents: solutions for the evolving problems of resistance

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (23), p.4235-4239

2003

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New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones: Antibacterial agents: solutions for the evolving problems of resistance

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (23), p.4209-4212

2003

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Effects of a Novel Hemoglobin-Based Oxygen Carrier on Percent Oxygen Saturation as Determined With Arterial Blood Gas Analysis and Pulse Oximetry

Annals of emergency medicine, 1996-02, Vol.27 (2), p.164-169

1996

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Metabolic chiral inversion of flurbiprofen-CoA In vitro

Biochemical pharmacology, 1991-06, Vol.42 (1), p.R1-R4

1991

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MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis

Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1)

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound

Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents

New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

Stereochemistry of the Carbonyl Reduction of MSDC‐0602, An mTOT‐modulating Insulin‐sensitizer for the Treatment of Nonalcoholic Steatohepatitis (NASH)

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Excretion mass balance and quantitative whole‐body autoradiography following a single oral (PO) administration of [14C]MSDC 0602, an mTOT‐modulating insulin sensitizer, in Sprague Dawley (SD) and Long‐Evans (LE) rats

Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs

Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors: Effect of 3-Alkylpyridine Ring Substitution

Structure, equilibrium conformation, and pseudorotation in cyclopentane. An electron diffraction study

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575)

Pharmacokinetics and systemic bioavailability of menogaril, and anthracycline antitumor agent, in the mouse, dog, and monkey

Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection

Liquid chromatographic determination of guanadrel in laboratory animal diet as the fluorescent acetylacetone derivative

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones: Antibacterial agents: solutions for the evolving problems of resistance

New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones: Antibacterial agents: solutions for the evolving problems of resistance

Effects of a Novel Hemoglobin-Based Oxygen Carrier on Percent Oxygen Saturation as Determined With Arterial Blood Gas Analysis and Pulse Oximetry

(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Metabolic chiral inversion of flurbiprofen-CoA In vitro

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