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Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (28), p.e2204174119-e2204174119

2022

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Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3511-3515

2007

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Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors

Bioorganic & medicinal chemistry letters, 2023-05, Vol.88, p.129304, Article 129304

2023

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LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy

Analytical biochemistry, 2020-08, Vol.602, p.113766-113766, Article 113766

2020

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Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127474-127474, Article 127474

2020

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Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway

American journal of physiology. Heart and circulatory physiology, 2000-06, Vol.278 (6), p.H1899-H1907

2000

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Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species

Journal of pharmaceutical sciences, 2018-05, Vol.107 (5), p.1352-1360

2018

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Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127495-127495, Article 127495

2020

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Benzothiazole-based compounds as potent endothelial lipase inhibitors

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126673-126673, Article 126673

2019

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Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation

American journal of physiology. Heart and circulatory physiology, 2002-02, Vol.282 (2), p.H602-H610

2002

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Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1660-1670

2020

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Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1918-1921

2019

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Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle

American Journal of Physiology: Cell Physiology, 2000-04, Vol.278 (4), p.C718-C726

2000

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Development of a Chemiluminescent ELISA Method for the Detection of Total Anti-Adeno Associated Virus Serotype 9 (AAV9) Antibodies

Human gene therapy. Part B. Methods, 2018-12, Vol.29 (6), p.237-250

2018

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Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (17), p.2525-2525

2019

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Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3721-3725

2018

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Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1263-1268

2018

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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9010-9026

2015

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Activation of Mitogen-Activated Protein Kinase in Porcine Carotid Arteries

Circulation research, 1995-02, Vol.76 (2), p.183-190

1995

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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.673-678

2018

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Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.911-916

2019

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Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.6162-6175

2012

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Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.860-864

2014

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Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6503-6508

2012

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p38 Mitogen-activated protein kinase expression and activation in smooth muscle

American Journal of Physiology: Cell Physiology, 1998-08, Vol.275 (2), p.C527-C534

1998

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Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors

LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway

Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species

Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Benzothiazole-based compounds as potent endothelial lipase inhibitors

Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase

Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle

Development of a Chemiluminescent ELISA Method for the Detection of Total Anti-Adeno Associated Virus Serotype 9 (AAV9) Antibodies

Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Activation of Mitogen-Activated Protein Kinase in Porcine Carotid Arteries

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

p38 Mitogen-activated protein kinase expression and activation in smooth muscle

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