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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Cell reports. Medicine, 2020-07, Vol.1 (4), p.100057-100057, Article 100057

2020

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Assessments of antibody biodistribution

Journal of clinical pharmacology, 2015-03, Vol.55 (S3), p.S29-S38

2015

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High-Throughput Method Development for Sensitive, Accurate, and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Tissues Using Orthogonal Array Optimization and Nano Liquid Chromatography/Selected Reaction Monitoring Mass Spectrometry

Analytical chemistry (Washington), 2012-05, Vol.84 (10), p.4373-4382

2012

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Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Frontiers in pharmacology, 2022-02, Vol.13, p.837744

2022

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Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

Journal of pharmacokinetics and pharmacodynamics, 2012-12, Vol.39 (6), p.683-710

2012

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Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Study

ACR open rheumatology, 2022-10, Vol.4 (10), p.903-911

2022

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Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers

Clinical therapeutics, 2021-01, Vol.43 (1), p.142-155.e5

2021

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Population Pharmacokinetic Modeling and Exposure–Efficacy and Body Weight–Response Analyses for Tezepelumab in Patients With Severe, Uncontrolled Asthma

Journal of clinical pharmacology, 2024-08, Vol.64 (8), p.908-921

2024

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Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain

Molecular pharmaceutics, 2013-05, Vol.10 (5), p.1505-1513

2013

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Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis

Gastroenterology (New York, N.Y. 1943), 2019-03, Vol.156 (4), p.946-957.e18

2019

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Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp Alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase I Clinical Trials

Clinical pharmacology and therapeutics, 2023-08, Vol.114 (2), p.371-380

2023

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Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody

International journal of pharmaceutics, 2012-12, Vol.439 (1-2), p.8-16

2012

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Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

International journal of pharmaceutics, 2013-02, Vol.444 (1-2), p.185-192

2013

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Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

The AAPS journal, 2012-09, Vol.14 (3), p.445-455

2012

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Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1906-1913

2014

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High-throughput Method Development for Sensitive, Accurate and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Tissues Using Orthogonal Array Optimization and Nano-LC/SRM-MS

Analytical chemistry (Washington), 2012-04, Vol.84 (10), p.4373-4382

2012

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Evaluation of the mechanistic determinants of antibody exposure in tissues

Abuqayyas, Lubna

2012

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Antibody Engineering and Therapeutics: December 8-12, 2013, Huntington Beach, CA

mAbs, 2014-05, Vol.6 (3), p.577-618

2014

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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Assessments of antibody biodistribution

High-Throughput Method Development for Sensitive, Accurate, and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Tissues Using Orthogonal Array Optimization and Nano Liquid Chromatography/Selected Reaction Monitoring Mass Spectrometry

Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer

Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Study

Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers

Population Pharmacokinetic Modeling and Exposure–Efficacy and Body Weight–Response Analyses for Tezepelumab in Patients With Severe, Uncontrolled Asthma

Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain

Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp Alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase I Clinical Trials

Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution

High-throughput Method Development for Sensitive, Accurate and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Tissues Using Orthogonal Array Optimization and Nano-LC/SRM-MS

Evaluation of the mechanistic determinants of antibody exposure in tissues

Antibody Engineering and Therapeutics: December 8-12, 2013, Huntington Beach, CA

Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA

Antibody Engineering and Therapeutics: December 8-12, 2013, Huntington Beach, CA

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