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Application and Validation of an Advanced Gastrointestinal In Vitro Model for the Evaluation of Drug Product Performance in Pharmaceutical Development

Journal of pharmaceutical sciences, 2014-11, Vol.103 (11), p.3704-3712

2014

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The gastrointestinal microbiota as a site for the biotransformation of drugs

International journal of pharmaceutics, 2008-11, Vol.363 (1), p.1-25

2008

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In vitro models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.342-366

2014

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In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

European journal of pharmaceutical sciences, 2013-07, Vol.49 (4), p.679-698

2013

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In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Molecular pharmaceutics, 2017-12, Vol.14 (12), p.4233-4242

2017

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Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristics

Journal of pharmaceutical sciences, 2015-09, Vol.104 (9), p.2956-2968

2015

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Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Journal of controlled release, 2019-06, Vol.304, p.90-100

2019

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Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies

Pharmaceutical research, 2006, Vol.23 (1), p.165-176

2006

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A stomach road or “Magenstrasse” for gastric emptying

Journal of biomechanics, 2007-01, Vol.40 (6), p.1202-1210

2007

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Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.232-239

2014

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The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

Journal of pharmacy and pharmacology, 2005-03, Vol.57 (3), p.273-285

2005

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Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

Pharmaceutical research, 2010-10, Vol.27 (10), p.2119-2130

2010

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A Novel Disintegration Tester for Solid Dosage Forms Enabling Adjustable Hydrodynamics

Journal of pharmaceutical sciences, 2016-08, Vol.105 (8), p.2402-2409

2016

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Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults

Pharmaceutical research, 2009-09, Vol.26 (9), p.2141-2151

2009

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Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Molecular pharmaceutics, 2016-09, Vol.13 (9), p.3022-3033

2016

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Kolliphor Surfactants Affect Solubilization and Bioavailability of Fenofibrate. Studies of in Vitro Digestion and Absorption in Rats

Molecular pharmaceutics, 2015-04, Vol.12 (4), p.1062-1071

2015

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Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation

European journal of pharmaceutical sciences, 2013-01, Vol.48 (1-2), p.339-350

2013

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Gastric flow and mixing studied using computer simulation

Proceedings of the Royal Society. B, Biological sciences, 2004-12, Vol.271 (1557), p.2587-2594

2004

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Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents

Pharmaceutical research, 2006-06, Vol.23 (6), p.1373-1381

2006

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The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

Pharmaceutical research, 2005-12, Vol.22 (12), p.2141-2151

2005

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Nanofibrous Scaffolds Support a 3D in vitro Permeability Model of the Human Intestinal Epithelium

Frontiers in pharmacology, 2019-05, Vol.10, p.456-456

2019

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Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Pharmaceutics, 2022-04, Vol.14 (4), p.801

2022

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Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans

Journal of pharmaceutical sciences, 2015-01, Vol.104 (1), p.135-143

2015

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Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Frontiers in medicine, 2021-03, Vol.8, p.480706-480706

2021

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Impact of the intragastric location of extended release tablets on food interactions

Journal of controlled release, 2005-11, Vol.108 (2-3), p.375-385

2005

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Application and Validation of an Advanced Gastrointestinal In Vitro Model for the Evaluation of Drug Product Performance in Pharmaceutical Development

The gastrointestinal microbiota as a site for the biotransformation of drugs

In vitro models for the prediction of in vivo performance of oral dosage forms

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristics

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies

A stomach road or “Magenstrasse” for gastric emptying

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

A Novel Disintegration Tester for Solid Dosage Forms Enabling Adjustable Hydrodynamics

Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Kolliphor Surfactants Affect Solubilization and Bioavailability of Fenofibrate. Studies of in Vitro Digestion and Absorption in Rats

Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation

Gastric flow and mixing studied using computer simulation

Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents

The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

Nanofibrous Scaffolds Support a 3D in vitro Permeability Model of the Human Intestinal Epithelium

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Impact of the intragastric location of extended release tablets on food interactions

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