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Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model

PLoS neglected tropical diseases, 2017-09, Vol.11 (9), p.e0005942-e0005942

2017

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An in vitro toolbox to accelerate anti-malarial drug discovery and development

Malaria journal, 2020-01, Vol.19 (1), p.1-1, Article 1

2020

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PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Clinical and translational science, 2024-07, Vol.17 (7), p.e13865-n/a

2024

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Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and translational science, 2024-04, Vol.17 (4), p.e13738-n/a

2024

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The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene

The Journal of pharmacology and experimental therapeutics, 2008-06, Vol.325 (3), p.859

2008

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Development and application of a PBPK modeling strategy to support antimalarial drug development

CPT: pharmacometrics and systems pharmacology, 2023-09, Vol.12 (9), p.1335-1346

2023

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Application of PBPK modeling to evaluate pharmacokinetic drug-drug interactions during the development of new antimalarial combination therapies

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S68-S69

2019

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Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7299-7317

2011

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Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis

Pharmaceutical research, 2005-12, Vol.22 (12), p.2069-2078

2005

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Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin

Journal of controlled release, 2005-11, Vol.108 (2-3), p.319-330

2005

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An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2

Toxicology and applied pharmacology, 2022-05, Vol.443, p.116006-116006, Article 116006

2022

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Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.481-490

2020

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Unanticipated CNS Safety Signal in a Placebo‐Controlled, Randomized Trial of Co‐Administered Atovaquone‐Proguanil and Amodiaquine

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.867-877

2022

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Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Pharmaceutical research, 2018-11, Vol.35 (11), p.210-13, Article 210

2018

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Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

Journal of pharmacokinetics and pharmacodynamics, 2018-10, Vol.45 (5), p.747-762

2018

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Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial

EBioMedicine, 2022-12, Vol.86, p.104322-104322, Article 104322

2022

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

Antimicrobial agents and chemotherapy, 2022-01, Vol.66 (1), p.e0158421

2022

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Identification and Optimization of an Aminoalcohol-Carbazole Series with Antimalarial Properties

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1037-1041

2013

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Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1304-1308

2017

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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

ACS infectious diseases, 2021-07, Vol.7 (7), p.1885-1893

2021

Volltextzugriff (PDF)

A fast screening strategy for characterizing peptide delivery by transdermal iontophoresis

Journal of controlled release, 2009-07, Vol.137 (2), p.123-129

2009

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Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Frontiers in immunology, 2014, Vol.5, p.233

2014

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Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery

Pharmaceutical research, 2006-08, Vol.23 (8), p.1842-1849

2006

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Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model

An in vitro toolbox to accelerate anti-malarial drug discovery and development

PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene

Development and application of a PBPK modeling strategy to support antimalarial drug development

Application of PBPK modeling to evaluate pharmacokinetic drug-drug interactions during the development of new antimalarial combination therapies

Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases

Effect of charge and molecular weight on transdermal peptide delivery by iontophoresis

Contributions of electromigration and electroosmosis to peptide iontophoresis across intact and impaired skin

An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2

Characterization of Novel PI3KÎ´ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction

Unanticipated CNS Safety Signal in a Placebo‐Controlled, Randomized Trial of Co‐Administered Atovaquone‐Proguanil and Amodiaquine

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trialResearch in context

Identification and Optimization of an Aminoalcohol-Carbazole Series with Antimalarial Properties

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

A fast screening strategy for characterizing peptide delivery by transdermal iontophoresis

Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery

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