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The Efficacy, Effectiveness, and Efficiency of Integrated QTc Assessment: Rationalizing Approaches to New Drug Modalities

Clinical pharmacology and therapeutics, 2024-07, Vol.116 (1), p.22-25

2024

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Return to SENDer: The Submitted Electronic Data for Nonclinical Cardiovascular Studies is Not Facilitating Transparency, Translation or Innovation

Clinical pharmacology and therapeutics, 2024-07

2024

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Revisiting the hERG safety margin after 20 years of routine hERG screening

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106900, Article 106900

2020

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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

Cell metabolism, 2022-09, Vol.34 (9), p.1234-1247.e9

2022

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A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates

Journal of pharmacological and toxicological methods, 2024-05, Vol.127, p.107510-107510, Article 107510

2024

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Improving the mechanical quality factor of ultra-low-loss silicon resonators

Journal of applied physics, 2018-06, Vol.123 (23)

2018

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Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation

Journal of pharmacological and toxicological methods, 2023-03, Vol.120, p.107253-107253, Article 107253

2023

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Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure

British journal of pharmacology, 2023-08, Vol.180 (15), p.1965-1980

2023

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The Safety Pharmacology of Auditory Function

Handbook of experimental pharmacology, 2015, Vol.229, p.267

Abernathy, Matthew M

2015

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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis

Journal of pharmacological and toxicological methods, 2023-05, Vol.121, p.107266-107266, Article 107266

2023

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Titania-doped tantala/silica coatings for gravitational-wave detection

Classical and quantum gravity, 2007-01, Vol.24 (2), p.405-415

2007

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

Regulatory toxicology and pharmacology, 2020-11, Vol.117, p.104746, Article 104746

2020

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

Clinical and translational science, 2021-05, Vol.14 (3), p.1133-1146

2021

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The failure to detect drug-induced sensory loss in standard preclinical studies

Journal of pharmacological and toxicological methods, 2015-07, Vol.74, p.53-74

2015

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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

International journal of toxicology, 2020-07, Vol.39 (4), p.274-293

2020

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International journal of toxicology, 2019-01, Vol.38 (1), p.23-32

2019

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Order, disorder and mixing: The atomic structure of amorphous mixtures of titania and tantala

Journal of non-crystalline solids, 2016-04, Vol.438 (C), p.59-66

2016

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An Overview of Research into Low Internal Friction Optical Coatings by the Gravitational Wave Detection Community

Materials research (São Carlos, São Paulo, Brazil), 2018-01, Vol.21 (suppl 2), p.1

2018

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Utility of the auditory brainstem response evaluation in non-clinical drug safety evaluations

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.111-117

2015

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Annealing and Extended Etching Improve a Torsional Resonator for Thin Film Internal Friction Measurements

Materials research (São Carlos, São Paulo, Brazil), 2018-01, Vol.21 (suppl 2), p.1

2018

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Manipulation of Glassy State in Amorphous Selenium by Low-temperature Internal Friction Measurements

Materials research (São Carlos, São Paulo, Brazil), 2018-01, Vol.21 (suppl 2), p.1

2018

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Will CiPA Add Value in Proarrhythmia Assessment?

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.199-200

2017

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Using the Same ICH S7B Assays to Predict TQT Outcome and Proarrhythmia

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.200-200

2017

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Order within disorder: The atomic structure of ion-beam sputtered amorphous tantala (a-Ta2O5)

APL materials, 2015-03, Vol.3 (3), p.036103-036103-6

2015

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Use of hERG binding in lead optimization provides greater predictivity for QTc prolongation in vivo compared to manual patch hERG assay

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.148-148

2018

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The Efficacy, Effectiveness, and Efficiency of Integrated QTc Assessment: Rationalizing Approaches to New Drug Modalities

Return to SENDer: The Submitted Electronic Data for Nonclinical Cardiovascular Studies is Not Facilitating Transparency, Translation or Innovation

Revisiting the hERG safety margin after 20 years of routine hERG screening

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates

Improving the mechanical quality factor of ultra-low-loss silicon resonators

Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation

Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure

The Safety Pharmacology of Auditory Function

The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis

Titania-doped tantala/silica coatings for gravitational-wave detection

Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

The failure to detect drug-induced sensory loss in standard preclinical studies

An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

Order, disorder and mixing: The atomic structure of amorphous mixtures of titania and tantala

An Overview of Research into Low Internal Friction Optical Coatings by the Gravitational Wave Detection Community

Utility of the auditory brainstem response evaluation in non-clinical drug safety evaluations

Annealing and Extended Etching Improve a Torsional Resonator for Thin Film Internal Friction Measurements

Manipulation of Glassy State in Amorphous Selenium by Low-temperature Internal Friction Measurements

Will CiPA Add Value in Proarrhythmia Assessment?

Using the Same ICH S7B Assays to Predict TQT Outcome and Proarrhythmia

Order within disorder: The atomic structure of ion-beam sputtered amorphous tantala (a-Ta2O5)

Use of hERG binding in lead optimization provides greater predictivity for QTc prolongation in vivo compared to manual patch hERG assay

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