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Defects in trafficking bridge Parkinson's disease pathology and genetics

Nature (London), 2016-11, Vol.539 (7628), p.207-216

2016

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LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Human molecular genetics, 2018-01, Vol.27 (2), p.385-395

2018

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Spinal cord injury reveals multilineage differentiation of ependymal cells

PLoS biology, 2008-07, Vol.6 (7), p.e182-e182

2008

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The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology

Neuron (Cambridge, Mass.), 2006-11, Vol.52 (4), p.587-593

2006

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Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

Nature (London), 2012-08, Vol.488 (7413), p.652-655

2012

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MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

Science (American Association for the Advancement of Science), 2007-08, Vol.317 (5842), p.1220-1224

2007

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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Molecular neurodegeneration, 2012-09, Vol.7 (1), p.48-48, Article 48

2012

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LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

Scientific reports, 2016-07, Vol.6 (1), p.29945-29945, Article 29945

2016

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DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

PLoS biology, 2004-11, Vol.2 (11), p.e362-e362

2004

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Instant Neurons: Directed Somatic Cell Reprogramming Models of Central Nervous System Disorders

Biological psychiatry (1969), 2014-06, Vol.75 (12), p.945-951

2014

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Parkinsonism genes: culprits and clues

Journal of neurochemistry, 2006-11, Vol.99 (4), p.1062-1072

2006

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CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer’s Disease Skin Fibroblasts

Cell reports (Cambridge), 2017-11, Vol.21 (7), p.1727-1736

2017

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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

PLoS biology, 2004-11, Vol.2 (11), p.e327-e327

2004

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Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

Neuron (Cambridge, Mass.), 2003-03, Vol.37 (5), p.735-749

2003

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Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons

PloS one, 2009-09, Vol.4 (9), p.e7007-e7007

2009

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Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

Cell systems, 2017-04, Vol.4 (4), p.404-415.e5

2017

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Reprogramming Therapeutics: iPS Cell Prospects for Neurodegenerative Disease

Neuron (Cambridge, Mass.), 2009-02, Vol.61 (3), p.337-339

2009

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Cooperative Transcription Activation by Nurr1 and Pitx3 Induces Embryonic Stem Cell Maturation to the Midbrain Dopamine Neuron Phenotype

Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (8), p.2874-2879

2006

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Parkinson's disease Mitochondrial damage control

Nature (London), 2010-02, Vol.463 (7282), p.744-745

Abeliovich, Asa

2010

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Neurobiology of disease, 2006-03, Vol.21 (3), p.541-548

2006

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Retraction Note: Integrative genomics identifies APOE ε4 effectors in Alzheimer’s disease

Nature (London), 2015-06, Vol.523 (7562), p.626-626

2015

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Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway

PLoS genetics, 2013-10, Vol.9 (10), p.e1003845-e1003845

2013

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Neurological disorders: Quality-control pathway unlocked

Nature (London), 2014-06, Vol.510 (7503), p.44-45

Abeliovich, Asa

2014

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Quality-control pathway unlocked

Nature (London), 2014-06, Vol.510 (7503), p.44-45

Abeliovich, Asa

2014

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Parkinson's disease: Guilt by genetic association

Nature (London), 2016-05, Vol.533 (7601), p.40-41

2016

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Defects in trafficking bridge Parkinson's disease pathology and genetics

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Spinal cord injury reveals multilineage differentiation of ependymal cells

The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

Instant Neurons: Directed Somatic Cell Reprogramming Models of Central Nervous System Disorders

Parkinsonism genes: culprits and clues

CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer’s Disease Skin Fibroblasts

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

Reprogramming Therapeutics: iPS Cell Prospects for Neurodegenerative Disease

Cooperative Transcription Activation by Nurr1 and Pitx3 Induces Embryonic Stem Cell Maturation to the Midbrain Dopamine Neuron Phenotype

Parkinson's disease Mitochondrial damage control

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Retraction Note: Integrative genomics identifies APOE ε4 effectors in Alzheimer’s disease

Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway

Neurological disorders: Quality-control pathway unlocked

Quality-control pathway unlocked

Parkinson's disease: Guilt by genetic association

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