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Mechanistic Studies of Two Dioxygenases in the Methionine Salvage Pathway of Klebsiella pneumoniae

Biochemistry (Easton), 2001-05, Vol.40 (21), p.6379-6387

2001

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One Protein, Two Enzymes

The Journal of biological chemistry, 1999-01, Vol.274 (3), p.1193-1195

1999

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Inhibition of serine proteases by peptidyl fluoromethyl ketones

Biochemistry (Easton), 1986-07, Vol.25 (13), p.3760-3767

1986

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Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors

Biochemistry (Easton), 1990-08, Vol.29 (33), p.7600-7607

1990

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Mechanism of Mevalonate Pyrophosphate Decarboxylase: Evidence for a Carbocationic Transition State

Biochemistry (Easton), 1994-11, Vol.33 (45), p.13355-13362

1994

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Inhibition of chymotrypsin by peptidyl trifluoromethyl ketones: determinants of slow-binding kinetics

Biochemistry (Easton), 1990-08, Vol.29 (33), p.7608-7617

1990

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Cysteine protease inhibition by azapeptide esters

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4279-4283

1992

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Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate

Biochemistry (Easton), 1986-09, Vol.25 (19), p.5609-5616

1986

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Inactivation of Cysteine Proteases by (Acyloxy)methyl Ketones Using S‘−P‘ Interactions

Biochemistry (Easton), 2000-05, Vol.39 (21), p.6498-6502

2000

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Role of serine 214 and tyrosine 171, components of the S2 subsite of .alpha.-lytic protease, in catalysis

Biochemistry (Easton), 1992-11, Vol.31 (45), p.11216-11223

1992

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Inhibitors of Human Heart Chymase Based on a Peptide Library

Proceedings of the National Academy of Sciences - PNAS, 1995-07, Vol.92 (15), p.6738-6742

1995

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Suicide inactivation of chymotrypsin by benzoxazinones

Biochemistry (Easton), 1984-04, Vol.23 (8), p.1753-1759

1984

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Fluoro ketone inhibitors of hydrolytic enzymes

Biochemistry (Easton), 1985-04, Vol.24 (8), p.1813-1817

1985

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Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogs

Biochemistry (Easton), 1987-07, Vol.26 (15), p.4717-4722

1987

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Complex of .alpha.-chymotrypsin and N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone: structural studies with NMR spectroscopy

Biochemistry (Easton), 1987-12, Vol.26 (24), p.7603-7608

1987

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From Poor Substrates to Good Inhibitors: Design of Inhibitors for Serine and Thiol Proteases

Biochemistry (Easton), 1996-03, Vol.35 (11), p.3351-3353

1996

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Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones

Biochemistry (Easton), 1989-10, Vol.28 (21), p.8466-8473

1989

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Inhibition of chymotrypsin by fluorinated .alpha.-keto acid derivatives

Biochemistry (Easton), 1992-10, Vol.31 (39), p.9429-9435

1992

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Role of peripheral side chains of vitamin B12 coenzymes in the reaction catalyzed by dioldehydrase

Biochemistry (Easton), 1979-02, Vol.18 (3), p.417-426

1979

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Conversion of .alpha.-Keto Esters into .beta.,.beta.-Difluoro-.alpha.-keto Esters and Corresponding Acids: A Simple Route to a Novel Class of Serine Protease Inhibitors

Journal of organic chemistry, 1995-08, Vol.60 (16), p.5174-5179

1995

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Modulation of Recombinant Human Prostate-Specific Antigen: Activation by Hofmeister Salts and Inhibition by Azapeptides † Appendix: Thermodynamic Interpretation of the Activation by Concentrated Salts

Biochemistry (Easton), 2001-10, Vol.40 (39), p.11734-11741

2001

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Reaction mechanism and structure of the active site of proline racemase

Biochemistry (Easton), 1975-10, Vol.14 (20), p.4515-4522

1975

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Studies on the mechanism of action of plasma amine oxidase

Biochemistry (Easton), 1978-08, Vol.17 (17), p.3538-3545

1978

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Acetylenic enzyme inactivators. Inactivation of .gamma.-cystathionase, in vitro and in vivo by propargylglycine

Journal of the American Chemical Society, 1973-09, Vol.95 (18), p.6124-6125

1973

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Chloroketone Hydrolysis by Chymotrypsin and N-Methylhistidyl-57-chymotrypsin: Implications for the Mechanism of Chymotrypsin Inactivation by Chloroketones

Biochemistry (Easton), 1994-08, Vol.33 (32), p.9784-9790

1994

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Mechanistic Studies of Two Dioxygenases in the Methionine Salvage Pathway of Klebsiella pneumoniae

One Protein, Two Enzymes

Inhibition of serine proteases by peptidyl fluoromethyl ketones

Structure of chymotrypsin-trifluoromethyl ketone inhibitor complexes: comparison of slowly and rapidly equilibrating inhibitors

Mechanism of Mevalonate Pyrophosphate Decarboxylase: Evidence for a Carbocationic Transition State

Inhibition of chymotrypsin by peptidyl trifluoromethyl ketones: determinants of slow-binding kinetics

Cysteine protease inhibition by azapeptide esters

Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate

Inactivation of Cysteine Proteases by (Acyloxy)methyl Ketones Using S‘−P‘ Interactions

Role of serine 214 and tyrosine 171, components of the S2 subsite of .alpha.-lytic protease, in catalysis

Inhibitors of Human Heart Chymase Based on a Peptide Library

Suicide inactivation of chymotrypsin by benzoxazinones

Fluoro ketone inhibitors of hydrolytic enzymes

Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogs

Complex of .alpha.-chymotrypsin and N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone: structural studies with NMR spectroscopy

From Poor Substrates to Good Inhibitors: Design of Inhibitors for Serine and Thiol Proteases

Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones

Inhibition of chymotrypsin by fluorinated .alpha.-keto acid derivatives

Role of peripheral side chains of vitamin B12 coenzymes in the reaction catalyzed by dioldehydrase

Conversion of .alpha.-Keto Esters into .beta.,.beta.-Difluoro-.alpha.-keto Esters and Corresponding Acids: A Simple Route to a Novel Class of Serine Protease Inhibitors

Modulation of Recombinant Human Prostate-Specific Antigen: Activation by Hofmeister Salts and Inhibition by Azapeptides † Appendix: Thermodynamic Interpretation of the Activation by Concentrated Salts

Reaction mechanism and structure of the active site of proline racemase

Studies on the mechanism of action of plasma amine oxidase

Acetylenic enzyme inactivators. Inactivation of .gamma.-cystathionase, in vitro and in vivo by propargylglycine

Chloroketone Hydrolysis by Chymotrypsin and N-Methylhistidyl-57-chymotrypsin: Implications for the Mechanism of Chymotrypsin Inactivation by Chloroketones

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