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Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone-based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease

Drug development research, 2023-09, Vol.84 (6), p.1231-1246

2023

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Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors

Drug development research, 2024-05, Vol.85 (3), p.e22193-n/a

2024

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Computational Prediction of the Potential Target of SARS‐CoV‐2 Inhibitor Plitidepsin via Molecular Docking, Dynamic Simulations and MM‐PBSA Calculations

Chemistry & biodiversity, 2022-02, Vol.19 (2), p.e202100719-n/a

2022

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Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides

Molecules (Basel, Switzerland), 2015-05, Vol.20 (5), p.8800-8815

2015

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Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1459

2018

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Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Molecules (Basel, Switzerland), 2024-03, Vol.29 (6), p.1309

2024

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Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

Scientific reports, 2022-07, Vol.12 (1), p.12821-12821, Article 12821

2022

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Novel Thiazolidinone/Thiazolo[3,2- a ]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

Molecules (Basel, Switzerland), 2018-06, Vol.23 (6), p.1420

2018

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Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1616-1630

2020

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Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

European journal of medicinal chemistry, 2014-10, Vol.85, p.480-486

2014

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Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

Molecules (Basel, Switzerland), 2020-04, Vol.25 (9), p.2031

2020

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Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.2635-2643

2022

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New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study

Molecules (Basel, Switzerland), 2023-11, Vol.28 (21), p.7455

2023

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Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.322-332

2019

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Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.384-392

2021

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Convenient Synthesis and Antimicrobial Activity of New 3-Substituted 5-(Benzofuran-2-yl)-pyrazole Derivatives

Archiv der Pharmazie (Weinheim), 2008-11, Vol.341 (11), p.734-739

2008

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One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.309-318

2018

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Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1300-1309

2020

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Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.531-541

2022

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New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

PloS one, 2017-07, Vol.12 (7), p.e0181241-e0181241

2017

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Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.2265-2282

2022

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Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.600-613

2017

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Design, Synthesis and Biological Assessment of N '-(2-Oxoindolin-3-ylidene)-6-methylimidazo[2,1- b ]thiazole-5-carbohydrazides as Potential Anti-Proliferative Agents toward MCF-7 Breast Cancer

Pharmaceuticals (Basel, Switzerland), 2024-02, Vol.17 (2), p.216

2024

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Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.1227-1240

2022

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Design, synthesis, and biological evaluation of furan-bearing pyrazolo[3,4-b]pyridines as novel inhibitors of CDK2 and P53-MDM2 protein-protein interaction

Drug development research, 2023-09, Vol.84 (6), p.1183-1203

2023

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Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone-based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease

Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors

Computational Prediction of the Potential Target of SARS‐CoV‐2 Inhibitor Plitidepsin via Molecular Docking, Dynamic Simulations and MM‐PBSA Calculations

Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity

Novel Thiazolidinone/Thiazolo[3,2- a ]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria

Convenient Synthesis and Antimicrobial Activity of New 3-Substituted 5-(Benzofuran-2-yl)-pyrazole Derivatives

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Design, Synthesis and Biological Assessment of N '-(2-Oxoindolin-3-ylidene)-6-methylimidazo[2,1- b ]thiazole-5-carbohydrazides as Potential Anti-Proliferative Agents toward MCF-7 Breast Cancer

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

Design, synthesis, and biological evaluation of furan-bearing pyrazolo[3,4-b]pyridines as novel inhibitors of CDK2 and P53-MDM2 protein-protein interaction

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