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Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats

Toxicological sciences, 2005-08, Vol.86 (2), p.427-435

2005

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Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes

Toxicological sciences, 2005-08, Vol.86 (2), p.436-443

2005

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Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study

Clinical pharmacology and therapeutics, 2011-06, Vol.89 (6), p.867-874

2011

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Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

The pharmacogenomics journal, 2003-12, Vol.3 (6), p.335-342

2003

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The effect of valproic acid on hepatic and plasma levels of 15-F 2t-isoprostane in rats

Free radical biology & medicine, 2003-06, Vol.34 (11), p.1435-1446

2003

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Valproic acid glucuronidation is associated with increases in 15-F 2t-isoprostane in rats

Free radical biology & medicine, 2005-06, Vol.38 (11), p.1471-1483

2005

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Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals

Drug metabolism and disposition, 2000-07, Vol.28 (7), p.823

2000

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Assessing the Mechanism of Metabolism-Dependent Valproic Acid-Induced in Vitro Cytotoxicity

Chemical research in toxicology, 1999-04, Vol.12 (4), p.323-330

1999

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Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkylidenebut-2-enoic Acids

Synthetic communications, 2004-12, Vol.34 (5), p.871-888

2004

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Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.114-121

2003

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Structure-Activity Relationships of Unsaturated Analogs of Valproic Acid

Journal of medicinal chemistry, 1995-08, Vol.38 (17), p.3398-3406

1995

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LC/MS analysis of hydroxylation products of salicylate as an indicator of in vivo oxidative stress

Free radical biology & medicine, 1999-04, Vol.26 (7), p.1054-1058

1999

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Metabolic profiling of valproic acid by cDNA-expressed human cytochrome P450 enzymes using negative-ion chemical ionization gas chromatography–mass spectrometry

Journal of chromatography. B, Biomedical sciences and applications, 2000-06, Vol.742 (2), p.217-227

2000

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Fluorinated Analogs as Mechanistic Probes in Valproic Acid Hepatotoxicity: Hepatic Microvesicular Steatosis and Glutathione Status

Chemical research in toxicology, 1995-07, Vol.8 (5), p.671-682

1995

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Bioactivation of a Toxic Metabolite of Valproic Acid, (E)-2-Propyl-2,4-pentadienoic Acid, via Glucuronidation. LC/MS/MS Characterization of the GSH−Glucuronide Diconjugates

Chemical research in toxicology, 1996, Vol.9 (2), p.517-526

1996

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Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolism studies in humans

Journal of mass spectrometry., 2000-06, Vol.35 (6), p.698-704

2000

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Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance

Drug metabolism and disposition, 2000-07, Vol.28 (7), p.845

2000

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Time course of alpha-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal gamma-aminobutyric acid levels in comparison to valproic acid

The Journal of pharmacology and experimental therapeutics, 1997-09, Vol.282 (3), p.1163

1997

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Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination

Drug metabolism and disposition, 2000-07, Vol.28 (7), p.857

2000

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Dose-dependent pharmacokinetics and metabolism of valproic acid in newborn lambs and adult sheep

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.664

2001

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Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases

Drug metabolism and disposition, 1996-04, Vol.24 (4), p.436

1996

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Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes

Toxicology (Amsterdam), 1996-08, Vol.112 (1), p.69-85

1996

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A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics

Drug metabolism and disposition, 1997-02, Vol.25 (2), p.219

1997

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Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.912

2000

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Characterization of Thiol-conjugated Metabolites of 2-Propylpent-4-enoic Acid (4-eneVPA), a Toxic Metabolite of Valproic Acid, by Electrospray Tandem Mass Spectrometry

Journal of mass spectrometry., 1996-08, Vol.31 (8), p.926-936

1996

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Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats

Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes

Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study

Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

The effect of valproic acid on hepatic and plasma levels of 15-F 2t-isoprostane in rats

Valproic acid glucuronidation is associated with increases in 15-F 2t-isoprostane in rats

Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals

Assessing the Mechanism of Metabolism-Dependent Valproic Acid-Induced in Vitro Cytotoxicity

Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkylidenebut-2-enoic Acids

Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients

Structure-Activity Relationships of Unsaturated Analogs of Valproic Acid

LC/MS analysis of hydroxylation products of salicylate as an indicator of in vivo oxidative stress

Metabolic profiling of valproic acid by cDNA-expressed human cytochrome P450 enzymes using negative-ion chemical ionization gas chromatography–mass spectrometry

Fluorinated Analogs as Mechanistic Probes in Valproic Acid Hepatotoxicity: Hepatic Microvesicular Steatosis and Glutathione Status

Bioactivation of a Toxic Metabolite of Valproic Acid, (E)-2-Propyl-2,4-pentadienoic Acid, via Glucuronidation. LC/MS/MS Characterization of the GSH−Glucuronide Diconjugates

Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolism studies in humans

Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance

Time course of alpha-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal gamma-aminobutyric acid levels in comparison to valproic acid

Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination

Dose-dependent pharmacokinetics and metabolism of valproic acid in newborn lambs and adult sheep

Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases

Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes

A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics

Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep

Characterization of Thiol-conjugated Metabolites of 2-Propylpent-4-enoic Acid (4-eneVPA), a Toxic Metabolite of Valproic Acid, by Electrospray Tandem Mass Spectrometry

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