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Protease Inhibitors: Current Status and Future Prospects

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.305-341

2000

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Single Turn Peptide Alpha Helices with Exceptional Stability in Water

Journal of the American Chemical Society, 2005-03, Vol.127 (9), p.2974-2983

2005

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Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino Acids

Journal of the American Chemical Society, 2001-01, Vol.123 (2), p.333-334

2001

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Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

Chemical reviews, 2005-03, Vol.105 (3), p.793-826

2005

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Isolation and Characterization of a Cone Snail Protease with Homology to CRISP Proteins of the Pathogenesis-related Protein Superfamily

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.31105-31110

2003

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Activity of Recombinant Dengue 2 Virus NS3 Protease in the Presence of a Truncated NS2B Co-factor, Small Peptide Substrates, and Inhibitors

The Journal of biological chemistry, 2001-12, Vol.276 (49), p.45762-45771

2001

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Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice

Journal of medicinal chemistry, 2010-12, Vol.53 (23), p.8400-8408

2010

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Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site

Biochemical and biophysical research communications, 2000-02, Vol.268 (1), p.133-135

2000

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A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

Kidney international, 2003-01, Vol.63 (1), p.134-142

2003

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Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs

Current medicinal chemistry, 2005-01, Vol.12 (25), p.2963-2977

2005

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Conformational Control by Thiazole and Oxazoline Rings in Cyclic Octapeptides of Marine Origin. Novel Macrocyclic Chair and Boat Conformations

Journal of the American Chemical Society, 1996-10, Vol.118 (43), p.10384-10388

1996

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Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between Structures and Activity

Molecular pharmacology, 2004-04, Vol.65 (4), p.868-879

2004

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Consecutive Cyclic Pentapeptide Modules Form Short α-Helices that are Very Stable to Water and Denaturants

Angewandte Chemie International Edition, 2004-05, Vol.43 (20), p.2687-2690

2004

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Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity

The FASEB journal, 2002-09, Vol.16 (11), p.1458-1460

2002

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Molecular diversity through sugar scaffolds

Drug Discovery Today, 2003-08, Vol.8 (15), p.701-709

2003

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Regioselective structural and functional mimicry of peptides. Design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease

Journal of the American Chemical Society, 1995-10, Vol.117 (41), p.10220-10226

1995

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Macrocyclic Peptidomimetics Forcing Peptides into Bioactive Conformations

Current medicinal chemistry, 1995-08, Vol.2 (2), p.654-686

1995

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Hookworm Aspartic Protease, Na-APR-2, Cleaves Human Hemoglobin and Serum Proteins in a Host-Specific Fashion

The Journal of infectious diseases, 2003-02, Vol.187 (3), p.484-494

2003

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Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes: Implications for Drug Design and Polypeptide Processing

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1271-1281

2000

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A Convergent Solution-Phase Synthesis of the Macrocycle Ac-Phe-[Orn-Pro-d-Cha-Trp-Arg], a Potent New Antiinflammatory Drug

Journal of organic chemistry, 2003-05, Vol.68 (11), p.4464-4471

2003

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Proteolysis of human hemoglobin by schistosome cathepsin D

Molecular and biochemical parasitology, 2001-01, Vol.112 (1), p.103-112

2001

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Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

Bioorganic & medicinal chemistry letters, 1996-11, Vol.6 (21), p.2531-2536

1996

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Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids

Journal of the American Chemical Society, 1999-03, Vol.121 (11), p.2603-2604

1999

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Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15

Biochemical journal, 2000-01, Vol.345 Pt 2 (2), p.351-356

2000

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A Novel Stable Inhibitor of Endopeptidases EC 3.4.24.15 and 3.4.24.16 Potentiates Bradykinin-Induced Hypotension

Hypertension (Dallas, Tex. 1979), 2000-02, Vol.35 (2), p.626-626

2000

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Protease Inhibitors: Current Status and Future Prospects

Single Turn Peptide Alpha Helices with Exceptional Stability in Water

Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino Acids

Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

Isolation and Characterization of a Cone Snail Protease with Homology to CRISP Proteins of the Pathogenesis-related Protein Superfamily

Activity of Recombinant Dengue 2 Virus NS3 Protease in the Presence of a Truncated NS2B Co-factor, Small Peptide Substrates, and Inhibitors

Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice

Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site

A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs

Conformational Control by Thiazole and Oxazoline Rings in Cyclic Octapeptides of Marine Origin. Novel Macrocyclic Chair and Boat Conformations

Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between Structures and Activity

Consecutive Cyclic Pentapeptide Modules Form Short α-Helices that are Very Stable to Water and Denaturants

Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity

Molecular diversity through sugar scaffolds

Regioselective structural and functional mimicry of peptides. Design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease

Macrocyclic Peptidomimetics Forcing Peptides into Bioactive Conformations

Hookworm Aspartic Protease, Na-APR-2, Cleaves Human Hemoglobin and Serum Proteins in a Host-Specific Fashion

Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes: Implications for Drug Design and Polypeptide Processing

A Convergent Solution-Phase Synthesis of the Macrocycle Ac-Phe-[Orn-Pro-d-Cha-Trp-Arg], a Potent New Antiinflammatory Drug

Proteolysis of human hemoglobin by schistosome cathepsin D

Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids

Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15

A Novel Stable Inhibitor of Endopeptidases EC 3.4.24.15 and 3.4.24.16 Potentiates Bradykinin-Induced Hypotension

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