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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Antimicrobial Agents and Chemotherapy, 1997-05, Vol.41 (5), p.1082-1093

1997

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Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile

Journal of hepatology, 1999-03, Vol.30 (3), p.376-382

1999

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The pharmacology of endosomal TLR agonists in viral disease

Biochemical Society transactions, 2007-12, Vol.35 (Pt 6), p.1468-1472

2007

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Monocyclic l-Nucleosides with Type 1 Cytokine-Inducing Activity

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.1019-1028

2000

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Antimicrobial Agents and Chemotherapy, 1992-12, Vol.36 (12), p.2686-2692

1992

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Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells

Antimicrobial Agents and Chemotherapy, 1994-06, Vol.38 (6), p.1230-1238

1994

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2-amino-6-methoxypurine arabinoside: an agent for T-cell malignancies

Cancer research (Chicago, Ill.), 1995-08, Vol.55 (15), p.3352-3356

1995

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Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides

Antimicrobial Agents and Chemotherapy, 1994-04, Vol.38 (4), p.868-871

1994

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Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks

Journal of Virology, 1994-12, Vol.68 (12), p.8321-8330

1994

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High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay

Antimicrobial Agents and Chemotherapy, 1993-03, Vol.37 (3), p.441-447

1993

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In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans

Antimicrobial Agents and Chemotherapy, 1996-02, Vol.40 (2), p.514-519

1996

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Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

Antimicrobial Agents and Chemotherapy, 1991-02, Vol.35 (2), p.322-328

1991

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(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes

Antimicrobial Agents and Chemotherapy, 1996-02, Vol.40 (2), p.520-523

1996

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6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

Antimicrobial Agents and Chemotherapy, 1991-05, Vol.35 (5), p.851-857

1991

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The Ribavirin Analog ICN 17261 Demonstrates Reduced Toxicity and Antiviral Effects with Retention of both Immunomodulatory Activity and Reduction of Hepatitis-Induced Serum Alanine Aminotransferase Levels

Antimicrobial Agents and Chemotherapy, 2000-05, Vol.44 (5), p.1276-1283

2000

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A Steady-state and Pre-steady-state Kinetic Analysis of the NTPase Activity Associated with the Hepatitis C Virus NS3 Helicase Domain

The Journal of biological chemistry, 1996-10, Vol.271 (40), p.24449-24457

1996

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Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol

Antimicrobial Agents and Chemotherapy, 1995-09, Vol.39 (9), p.1993-1999

1995

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5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

Antimicrobial Agents and Chemotherapy, 1994-07, Vol.38 (7), p.1590-1603

1994

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Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme

The Journal of biological chemistry, 1983-08, Vol.258 (16), p.9831-9838

1983

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2-acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a Potent Inactivator of Ribonucleotide Reductases of Herpes Simplex and Varicella-Zoster Viruses and a Potentiator of Acyclovir

Proceedings of the National Academy of Sciences - PNAS, 1989-02, Vol.86 (3), p.1051-1055

1989

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Regulation of both gene expression and protein stability provides genetically assisted target evaluation (GATE) for microbial target validation

Pharmacogenomics, 2001-05, Vol.2 (2), p.95-106

2001

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Inhibition of Borna Disease Virus Replication by Ribavirin

Journal of Virology, 1999-09, Vol.73 (9), p.7903-7906

1999

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Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model

Antimicrobial Agents and Chemotherapy, 1994-03, Vol.38 (3), p.616-619

1994

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Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

Hepatology (Baltimore, Md.), 2005-09, Vol.42 (3), p.724-731

2005

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A competitive enzyme-linked immunosorbent assay to quantitate acyclovir and BW B759U in human plasma and urine

Antimicrobial Agents and Chemotherapy, 1986-01, Vol.29 (1), p.93-98

1986

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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile

The pharmacology of endosomal TLR agonists in viral disease

Monocyclic l-Nucleosides with Type 1 Cytokine-Inducing Activity

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells

2-amino-6-methoxypurine arabinoside: an agent for T-cell malignancies

Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides

Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks

High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay

In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes

6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

The Ribavirin Analog ICN 17261 Demonstrates Reduced Toxicity and Antiviral Effects with Retention of both Immunomodulatory Activity and Reduction of Hepatitis-Induced Serum Alanine Aminotransferase Levels

A Steady-state and Pre-steady-state Kinetic Analysis of the NTPase Activity Associated with the Hepatitis C Virus NS3 Helicase Domain

Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol

5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme

2-acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a Potent Inactivator of Ribonucleotide Reductases of Herpes Simplex and Varicella-Zoster Viruses and a Potentiator of Acyclovir

Regulation of both gene expression and protein stability provides genetically assisted target evaluation (GATE) for microbial target validation

Inhibition of Borna Disease Virus Replication by Ribavirin

Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

A competitive enzyme-linked immunosorbent assay to quantitate acyclovir and BW B759U in human plasma and urine

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