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Insights in AAV-mediated antigen-specific immunity and a strategy for AAV vaccine dose reduction through AAV-extracellular vesicle association

Molecular therapy. Methods & clinical development, 2024-12, Vol.32 (4), p.101358, Article 101358

2024

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AAV-DJ is superior to AAV9 for targeting brain and spinal cord, and de-targeting liver across multiple delivery routes in mice

Journal of translational medicine, 2024-09, Vol.22 (1), p.824-14, Article 824

2024

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Effects of Fibrotic Border Zone on Drivers for Atrial Fibrillation: An In-Silico Mechanistic Investigation

Statistical Atlases and Computational Models of the Heart. Regular and CMRxRecon Challenge Papers, 2024, Vol.14507, p.174-185

2024

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Multiparametric domain insertional profiling of adeno-associated virus VP1

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101143, Article 101143

2023

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Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Genes, 2023-09, Vol.14 (10), p.1866

2023

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Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Journal of extracellular vesicles, 2023-06, Vol.12 (6), p.e12324-n/a

2023

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Tumor antigen-loaded AAV vaccine drives protective immunity in a melanoma animal model

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.301-311

2023

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Multiplexing AAV Serotype-Specific Neutralizing Antibodies in Preclinical Animal Models and Humans

Biomedicines, 2023-02, Vol.11 (2), p.523

2023

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Endovascular management of spontaneous intracranial pseudoaneurysms in a pediatric patient with Noonan syndrome. A mere coincidence or a possible association with the disorder?

Surgical neurology international, 2021-10, Vol.12, p.537, Article 537

2021

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Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration

Gene, 2020-12, Vol.763, p.100037-100037, Article 100037

2020

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Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Human gene therapy, 2020-10, Vol.31 (19-20), p.1124-1131

2020

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Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway

Scientific reports, 2020-09, Vol.10 (1), p.15874-15874, Article 15874

2020

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Development of AAV6-based vaccine with prime-boost capacity by using exosome-protected viral particles

The Journal of immunology (1950), 2020-05, Vol.204 (1_Supplement), p.91-91.24

2020

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An AAV6-based multi-antigen vaccine for treatment of murine melanoma

The Journal of immunology (1950), 2020-05, Vol.204 (1_Supplement), p.169-169.10

2020

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An Engineered AAV6-Based Vaccine Induces High Cytolytic Anti-Tumor Activity by Directly Targeting DCs and Improves Ag Presentation

Molecular therapy. Oncolytics, 2019-12, Vol.15, p.166-177

2019

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Abstract 1467: Bioengineering AAV6 vector-based vaccine for cancer treatment

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1467-1467

2019

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An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Molecular therapy. Methods & clinical development, 2018-06, Vol.9, p.296-304

2018

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Neutrophil elastase activates MMPs in macrophages and promotes adhesion and cytokine expression through the integrin – Srk pathway

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.102-102.11

2018

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Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity

American journal of respiratory cell and molecular biology, 2017-08, Vol.57 (2), p.238-247

2017

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11. The Role of Glucocorticoid Receptor Signaling in Adeno-Associated Virus 2 Infection

Molecular therapy, 2016-05, Vol.24, p.S6-S6

2016

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196. Nordihydroguaiaretic Acid (NDGA) Improves Function of Antigen-Specific T-Cells Stimulated by Capsid-Optimized AAV6 Vectors

Molecular therapy, 2016-05, Vol.24, p.S76-S77

2016

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10. High-Efficiency Transduction of Primary Human CD34+ Hematopoietic Stem/Progenitor Cells by AAV6 Serotype Vectors: Strategies for Overcoming Donor Variation and Implications in Genome Editing

Molecular therapy, 2016-05, Vol.24, p.S5-S6

2016

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548. Recombinant AAV3 Serotype Vectors Generated by Using AAV3 ITRs and AAV3 Rep Proteins Efficiently Transduce Human Liver Cancer Cell Lines In Vitro and Human Liver Tumors in a Murine Xenograft Model In Vivo

Molecular therapy, 2016-05, Vol.24, p.S219-S220

2016

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91. Development of Optimized [“Opt”] AAV Vectors by Combining Capsid-Modified NextGen and Genome-Modified GenX AAV Vectors for High-Efficiency Transduction at Further Reduced Doses

Molecular therapy, 2016-05, Vol.24, p.S39-S40

2016

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Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

Molecular therapy. Methods & clinical development, 2016-01, Vol.3 (C), p.16029-16029, Article 16029

2016

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Insights in AAV-mediated antigen-specific immunity and a strategy for AAV vaccine dose reduction through AAV-extracellular vesicle association

AAV-DJ is superior to AAV9 for targeting brain and spinal cord, and de-targeting liver across multiple delivery routes in mice

Effects of Fibrotic Border Zone on Drivers for Atrial Fibrillation: An In-Silico Mechanistic Investigation

Multiparametric domain insertional profiling of adeno-associated virus VP1

Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

Tumor antigen-loaded AAV vaccine drives protective immunity in a melanoma animal model

Multiplexing AAV Serotype-Specific Neutralizing Antibodies in Preclinical Animal Models and Humans

Endovascular management of spontaneous intracranial pseudoaneurysms in a pediatric patient with Noonan syndrome. A mere coincidence or a possible association with the disorder?

Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration

Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway

Development of AAV6-based vaccine with prime-boost capacity by using exosome-protected viral particles

An AAV6-based multi-antigen vaccine for treatment of murine melanoma

An Engineered AAV6-Based Vaccine Induces High Cytolytic Anti-Tumor Activity by Directly Targeting DCs and Improves Ag Presentation

Abstract 1467: Bioengineering AAV6 vector-based vaccine for cancer treatment

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy

Neutrophil elastase activates MMPs in macrophages and promotes adhesion and cytokine expression through the integrin – Srk pathway

Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity

11. The Role of Glucocorticoid Receptor Signaling in Adeno-Associated Virus 2 Infection

196. Nordihydroguaiaretic Acid (NDGA) Improves Function of Antigen-Specific T-Cells Stimulated by Capsid-Optimized AAV6 Vectors

10. High-Efficiency Transduction of Primary Human CD34+ Hematopoietic Stem/Progenitor Cells by AAV6 Serotype Vectors: Strategies for Overcoming Donor Variation and Implications in Genome Editing

548. Recombinant AAV3 Serotype Vectors Generated by Using AAV3 ITRs and AAV3 Rep Proteins Efficiently Transduce Human Liver Cancer Cell Lines In Vitro and Human Liver Tumors in a Murine Xenograft Model In Vivo

91. Development of Optimized [“Opt”] AAV Vectors by Combining Capsid-Modified NextGen and Genome-Modified GenX AAV Vectors for High-Efficiency Transduction at Further Reduced Doses

Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

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