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Statistical Considerations on Clinical Efficacy Studies of Biosimilar for PMDA Submission

Therapeutic innovation & regulatory science, 2020-09, Vol.54 (5), p.1134-1137

2020

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Phase 1 Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Garadacimab (CSL312) in Healthy Japanese and Caucasian Adults

Journal of allergy and clinical immunology, 2023-02, Vol.151 (2), p.AB144-AB144

2023

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Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats

Pharmacology, 1996-05, Vol.52 (5), p.303

1996

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Tolerability and efficacy of the long-term administration of memantine hydrochloride (Memary®) in patients with moderate to severe Alzheimer's disease

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2014, Vol.51(1), pp.74-84

2014

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HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits

Life sciences (1973), 1998, Vol.62 (12), p.1055-1063

1998

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Tolerability and efficacy of the long-term administration of memantine hydrochloride (Memary^|^reg;) in patients with moderate to severe Alzheimer's disease

Nihon Rōnen Igakkai zasshi, 2014, Vol.51 (1), p.74-84

2014

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Stimulation of cholesterol release from rabbit foam cells by the action of a new inhibitor for acyl CoA:cholesterol acyltransferase (ACAT), HL-004

The Journal of pharmacology and experimental therapeutics, 1998-10, Vol.287 (1), p.115

1998

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Up-regulation of low density lipoprotein receptor by a novel isobenzofranone derivative, MD-700

Atherosclerosis, 1999-10, Vol.146 (2), p.281-290

1999

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メマンチン塩酸塩（メマリー®）の中等度および高度アルツハイマー型認知症に対する長期投与時の忍容性ならびに有効性の検討

日本老年医学会雑誌, 2014, Vol.51(1), pp.74-84

2014

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Studies on hypolipidemic agents. IV. 3-(4-(Phenylthio)benzoyl)propionic acid derivatives

Chemical & pharmaceutical bulletin, 1989, Vol.37 (5), p.1260-1267

1989

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Studies on Hypolipidemic Agents. II. 3-(4-Phenoxybenzoyl)-propionic Acid Derivatives

Chemical and Pharmaceutical Bulletin, 1985/06/25, Vol.33(6), pp.2386-2394

1985

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Effect of the ACAT inhibitor HL-004 on cholesterol metabolism in macrophages

Japanese Journal of Pharmacology, 1996, Vol.71 (suppl.1), p.149-149

1996

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Studies on Hypolipidemic Agents. III. : ω-(4-Phenoxybenzyl)-alkanoic Acid Derivatives

Chemical and Pharmaceutical Bulletin, 1986/02/25, Vol.34(2), pp.701-712

1986

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Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models

Japanese Journal of Pharmacology, 1996, Vol.71 (suppl.1), p.149-149

1996

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ISOZYME PATTERNS OF PYRUVATE KINASE AND DIFFERENTIATION OF FRIEND LEUKEMIA CELLS

GANN Japanese Journal of Cancer Research, 1980/02/29, Vol.71(1), pp.146-150

1980

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Studies on Hypolipidemic Agents. IV

Chemical & pharmaceutical bulletin, 1989-05, Vol.37 (5), p.1260

1989

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Studies on Hypolipidemic Agents. III

Chemical & pharmaceutical bulletin, 1986-02, Vol.34 (2), p.701

1986

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Studies on Hypolipidemic Agents. IV. : 3-[4-(Phenylthio)benzoyl]propionic Acid Derivatives

Chemical and Pharmaceutical Bulletin, 1989/05/25, Vol.37(5), pp.1260-1267

1989

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P-363 - Effect of the ACAT inhibitor HL-004 on cholesterol metabolism in macrophages

Japanese journal of pharmacology, 1996, Vol.71, p.149-149

1996

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The ACAT Inhibitor HL-004 Inhibits Cholesterol Absorption and Lowers Serum Cholesterol in Rats

General pharmacology, 1998-10, Vol.31 (4), p.593-596

1998

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P-362 - Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models

Japanese journal of pharmacology, 1996, Vol.71, p.149-149

1996

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Effect of Diphenylsulfide analogues on lipid metabolism in rats

Japanese journal of pharmacology, 1987, Vol.43, p.208-208

1987

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The hypolipidemic action of the ACAT inhibitor HL-004 in hamsters fed normal chow

General pharmacology, 1996-12, Vol.27 (8), p.1383-1386

1996

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Systemic transport of trans-zeatin and its precursor have differing roles in Arabidopsis shoots

Nature plants, 2017-07, Vol.3, p.17112

2017

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A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma

Scientific reports, 2017-08, Vol.7 (1), p.8951-12, Article 8951

2017

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Statistical Considerations on Clinical Efficacy Studies of Biosimilar for PMDA Submission

Phase 1 Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Garadacimab (CSL312) in Healthy Japanese and Caucasian Adults

Hypolipidemic effect of taurine in stroke-prone spontaneously hypertensive rats

Tolerability and efficacy of the long-term administration of memantine hydrochloride (Memary®) in patients with moderate to severe Alzheimer's disease

HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits

Tolerability and efficacy of the long-term administration of memantine hydrochloride (Memary^|^reg;) in patients with moderate to severe Alzheimer's disease

Stimulation of cholesterol release from rabbit foam cells by the action of a new inhibitor for acyl CoA:cholesterol acyltransferase (ACAT), HL-004

Up-regulation of low density lipoprotein receptor by a novel isobenzofranone derivative, MD-700

メマンチン塩酸塩（メマリー®）の中等度および高度アルツハイマー型認知症に対する長期投与時の忍容性ならびに有効性の検討

Studies on hypolipidemic agents. IV. 3-(4-(Phenylthio)benzoyl)propionic acid derivatives

Studies on Hypolipidemic Agents. II. 3-(4-Phenoxybenzoyl)-propionic Acid Derivatives

Effect of the ACAT inhibitor HL-004 on cholesterol metabolism in macrophages

Studies on Hypolipidemic Agents. III. : ω-(4-Phenoxybenzyl)-alkanoic Acid Derivatives

Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models

ISOZYME PATTERNS OF PYRUVATE KINASE AND DIFFERENTIATION OF FRIEND LEUKEMIA CELLS

Studies on Hypolipidemic Agents. IV

Studies on Hypolipidemic Agents. III

Studies on Hypolipidemic Agents. IV. : 3-[4-(Phenylthio)benzoyl]propionic Acid Derivatives

P-363 - Effect of the ACAT inhibitor HL-004 on cholesterol metabolism in macrophages

The ACAT Inhibitor HL-004 Inhibits Cholesterol Absorption and Lowers Serum Cholesterol in Rats

P-362 - Effects of a novel ACAT inhibitor HL-004 on cholesterol absorption in cholesterol-fed models

Effect of Diphenylsulfide analogues on lipid metabolism in rats

The hypolipidemic action of the ACAT inhibitor HL-004 in hamsters fed normal chow

Systemic transport of trans-zeatin and its precursor have differing roles in Arabidopsis shoots

A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma

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